Electromagnetic Fields and Stem Cell Fate: When Physics Meets Biology

  • Sara Hassanpour Tamrin
  • Fatemeh Sadat Majedi
  • Mahdi Tondar
  • Amir Sanati-Nezhad
  • Mohammad Mahdi Hasani-Sadrabadi
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 171)

Abstract

Controlling stem cell (SC) fate is an extremely important topic in the realm of SC research. A variety of different external cues mainly mechanical, chemical, or electrical stimulations individually or in combination have been incorporated to control SC fate. Here, we will deconstruct the probable relationship between the functioning of electromagnetic (EMF) and SC fate of a variety of different SCs. The electromagnetic (EM) nature of the cells is discussed with the emphasis on the effects of EMF on the determinant factors that directly and/or indirectly influence cell fate. Based on the EM effects on a variety of cellular processes, it is believed that EMFs can be engineered to provide a controlled signal with the highest impact on the SC fate decision. Considering the novelty and broad applications of applying EMFs to change SC fate, it is necessary to shed light on many unclear mechanisms underlying this phenomenon.

Keywords

Differentiation Electromagnetic field Self-renewal Stem cell fate Stem cell niche 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Sara Hassanpour Tamrin
    • 1
  • Fatemeh Sadat Majedi
    • 2
  • Mahdi Tondar
    • 3
  • Amir Sanati-Nezhad
    • 4
  • Mohammad Mahdi Hasani-Sadrabadi
    • 5
    • 6
  1. 1.Center of Excellence in Biomaterials, Department of Biomedical EngineeringAmirkabir University of TechnologyTehranIran
  2. 2.Department of BioengineeringUniversity of CaliforniaLos AngelesUSA
  3. 3.Department of Biochemistry and Molecular & Cellular Biology, School of MedicineGeorgetown UniversityWashington, DCUSA
  4. 4.BioMEMS and BioInspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, Center for Bioengineering Research and EducationUniversity of CalgaryCalgaryCanada
  5. 5.Department of Chemistry & Biochemistry, and California NanoSystems InstituteUniversity of California at Los AngelesLos AngelesUSA
  6. 6.Parker H. Petit Institute for Bioengineering and Bioscience and G.W. Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaUSA

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