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Nanogels Capable of Triggered Release

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Tunable Hydrogels

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 178))

Abstract

This chapter provides an overview of soft and environmentally sensitive polymeric nanosystems, which are widely known as nanogels. These particles keep great promise to the area of drug delivery due to their high biocompatibility with body fluids and tissues, as well as due to their ability to encapsulate and release the loaded drugs in a controlled manner. For a long period of time, the controlled drug delivery systems were designed to provide long-termed or sustained release. However, some medical treatments such as cancer chemotherapy, protein and gene delivery do not require the prolonged release of the drug in the site of action. In contrast, the rapid increase of the drug concentration is needed for gaining the desired biological effect. Being very sensitive to surrounding media and different stimuli, nanogels can undergo physico-chemical transitions or chemical changes in their structure. Such changes can result in more rapid release of the drugs, which is usually referred to as triggered drug release. Herein we give the basic information on nanogel unique features, methods of sensitive nanogels preparation, as well as on main mechanisms of triggered release. Additionally, the triggered release of low-molecular drugs and biomacromolecules are discussed.

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Acknowledgements

Funding: The authors are grateful to Russian Science Foundation (project no. 19-73-10045) for financial support.

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  1. Laboratory of Biomedical Chemistry, Institute of Chemistry, St Petersburg University, St Petersburg, Russia

    Viktor Korzhikov-Vlakh & Tatiana Tennikova

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  1. Viktor Korzhikov-Vlakh
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  2. Tatiana Tennikova
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Correspondence to Viktor Korzhikov-Vlakh .

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  1. Institute of Technical Chemistry, Leibniz University of Hannover, Hannover, Germany

    Antonina Lavrentieva

  2. Institute of Technical Chemistry, Leibniz University of Hannover, Hannover, Germany

    Iliyana Pepelanova

  3. Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    Dror Seliktar

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Korzhikov-Vlakh, V., Tennikova, T. (2021). Nanogels Capable of Triggered Release. In: Lavrentieva, A., Pepelanova, I., Seliktar, D. (eds) Tunable Hydrogels. Advances in Biochemical Engineering/Biotechnology, vol 178. Springer, Cham. https://doi.org/10.1007/10_2021_163

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