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Smads In Mesenchymal Differentiation

  • Chapter
Smad Signal Transduction

Part of the book series: Proteins and Cell Regulation ((PROR,volume 5))

Abstract

Transforming growth factor-β (TGF-β) family members play key roles in development through their regulatory roles in cell and tissue differentiation. Among the differentiation lineages, mesenchymal tissue differentiation into bone, fat, cartilage or muscle is strongly regulated by TGF-β family members. Smads have shown themselves to function as cell-intrinsic regulators of mesenchymal stem cell differentiation into osteoblasts, adipocytes, chondrocytes and myocytes. Their activities are defined by autocrine and paracrine signals from TGF-β family members, and regulate the proliferation of the mesenchymal progenitor cell pool, the selection of the lineage along which the cells will differentiate, and the progression of differentiation. At the molecular level, Smads can inhibit progression of differentiation, through functional repression of key transcription factors that drive differentiation, or alternatively activate the expression, or enhance the activities, of such transcription factors to drive the selection of a lineage and progression along a particular lineage

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Authors and Affiliations

  1. Departments of Cell and Tissue Biology, and Anatomy, Programs in Cell Biology and Developmental Biology, University ofCalifornia, San Francisco, CA 94143

    Rik Derynck, Lisa Choy & Tamara Alliston

Authors
  1. Rik Derynck
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  2. Lisa Choy
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  3. Tamara Alliston
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Editors and Affiliations

  1. Leiden University Medical Center, Leiden, The Netherlands

    Peter ten Dijke

  2. Ludwig Institute for Cancer Research, Uppsala University, Sweden

    Carl-Henrik Heldin

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© 2006 Springer

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Derynck, R., Choy, L., Alliston, T. (2006). Smads In Mesenchymal Differentiation. In: Dijke, P.t., Heldin, CH. (eds) Smad Signal Transduction. Proteins and Cell Regulation, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4709-6_5

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