Smad Signal Transduction

Smads in Proliferation, Differentiation and Disease

  • Peter ten Dijke
  • Carl-Henrik Heldin

Part of the Proteins and Cell Regulation book series (PROR, volume 5)

Table of contents

  1. Front Matter
    Pages I-13
  2. Stuart J. Newfeld, Robert G. Wisotzkey
    Pages 15-35
  3. Richard W. Padgett, Garth I. Patterson
    Pages 37-53
  4. Laurel A. Raftery, Svetlana Korochkina, Jing Cao
    Pages 55-73
  5. Rik Derynck, Lisa Choy, Tamara Alliston
    Pages 93-112
  6. Andrew R. Conery, Kunxin Luo
    Pages 113-129
  7. Aristidis Moustakas, Marcin Kowanetz, Sylvie Thuault
    Pages 131-150
  8. Christine Le Roy, Rohit Bose, Jeffrey L. Wrana
    Pages 177-191
  9. Bernhard Schmierer, Caroline S. Hill
    Pages 193-213
  10. Ihor Yakymovych, Serhiy Souchelnytskyi
    Pages 235-252
  11. Kohei Miyazono, Shingo Maeda, Takeshi Imamura
    Pages 277-293
  12. Etienne Labbé, Liliana Attisano
    Pages 295-316
  13. Delphine Javelaud, Alain Mauviel
    Pages 317-334
  14. Erwin P. Böttinger, Wenjun Ju
    Pages 335-360
  15. Muneesh Tewari, Arvind Rao
    Pages 361-378
  16. Seong-Jin Kim, John J. Letterio
    Pages 397-413
  17. Michael Lahn, Brandi Berry, Susanne Kloeker, Jonathan M. Yingling
    Pages 415-442
  18. Nicholas J. Laping, StÉphane Huet
    Pages 443-459
  19. Back Matter
    Pages 461-472

About this book


For the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.


evolution gene expression genes molecular evolution proteins regulation signal transduction transcription

Editors and affiliations

  • Peter ten Dijke
    • 1
  • Carl-Henrik Heldin
    • 2
  1. 1.Leiden University Medical CenterLeidenThe Netherlands
  2. 2.Ludwig Institute for Cancer ResearchUppsala UniversitySweden

Bibliographic information