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PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas

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Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Ever since the discovery of the transforming retroviral v-sis oncogene, which encodes PDGF-B, PDGF signaling has been an interesting target for cancer treatment. In the last few years, compelling evidence supports the essential role of PDGF signaling for cancer cell proliferation and tumor angiogenesis in several types of human cancers, including nonmelanoma skin cancers. BCCs, the commonest human cancer, contain activation of the hedgehog pathway, frequently through inactivated mutations of tumor suppressor gene PTCH1. How does activation of the hedgehog pathway promote cell proliferation in the tumor? Our data indicate that PDGFRα activation is important for hedgehog signaling-mediated cell proliferation in BCCs. These findings not only detail the molecular basis of hedgehog-mediated tumorigenesis but also provide new designs for skin cancer therapeutics.

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Authors and Affiliations

  1. Sealy Center for Cancer Cell Biology, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 300 University Blvd., MRB 9.104, Galveston, Texas, 77555-1048, USA

    Jingwu Xie

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  1. Jingwu Xie
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© 2006 Landes Bioscience and Springer Science+Business Media

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Xie, J. (2006). PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas. In: Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-35098-5_10

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