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C5b-9 Complement Complex in Autoimmune Demyelination: Dual Role in Neuroinflammation and Neuroprotection

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Current Topics in Complement

Part of the book series: Advances in Experimental Medicine and Biology ((volume 586))

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6. References

  1. L. Steinman, Multiple sclerosis: a two-stage disease, Nat Immunol 2(9), 762–764 (2001).

    Article  PubMed  CAS  Google Scholar 

  2. M. Greter, F.L. Heppner, M.P. Lemos, et al., Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis, Nat Med 11(3), 328–334 (2005).

    Article  PubMed  CAS  Google Scholar 

  3. E.J. McMahon, S.L. Bailey, C.V. Castenada, H. Waldner, and S.D. Miller, Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis, Nat Med 11(3), 335–339 (2005).

    Article  PubMed  CAS  Google Scholar 

  4. F.L. Heppner, M. Greter, D. Marino, et al., Experimental autoimmune encephalo-myelitis repressed by microglial paralysis, Nat Med 11(2), 146–152 (2005).

    Article  PubMed  CAS  Google Scholar 

  5. C. Lucchinetti, W. Bruck, and J. Noseworthy, Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment, Curr Opin Neurol 14(3), 259–269 (2001).

    Article  PubMed  CAS  Google Scholar 

  6. M. Reindl, C. Linington, U. Brehm, et al., Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study, Brain 122(11), 2047–2056 (1999).

    Article  PubMed  Google Scholar 

  7. R. Egg, M. Reindl, F. Deisenhammer, C. Linington, and T. Berger, Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis, Mult Scler 7(5), 285–289 (2001).

    PubMed  CAS  Google Scholar 

  8. P. Vanguri, C. L. Koski, B. Silverman, and M.L. Shin, Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies, Proc Natl Acad Sci USA 79(10), 3290–3294 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. D.R. Wren and M. Noble, Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody, Proc Natl Acad Sci USA 86(22), 9025–9029 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. A.J. Biber, S. Kerr, and M. Rodriguez, Efficient central nervous system remyelination requires T cells, Ann Neurol 53(5), 680–684 (2003).

    Article  Google Scholar 

  11. R. Hohlfeld, M. Kerschensteiner, C. Stadelmann, H. Lassmann, and H. Wekerle, The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis, J Neuroimmunol 107(2), 161–166 (2000).

    Article  PubMed  CAS  Google Scholar 

  12. L.T. Diemel, C. A. Copelman, and M.L. Cuzner, Macrophages in CNS remyelination: friend or foe? Neurochem Res 23(3), 341–347 (1998).

    Article  PubMed  CAS  Google Scholar 

  13. J. Correale, and A. Villa, The neuroprotective role of inflammation in nervous system injuries, J Neurol 251(11), 1304–1316 (2004).

    Article  PubMed  Google Scholar 

  14. L.T. Diemel, S.J. Jackson, and M.L. Cuzner, Role for TGF-beta1, FGF-2 and PDGF-AA in a myelination of CNS aggregate cultures enriched with macrophages, J Neurosci Res 74(6), 858–867 (2003).

    Article  PubMed  CAS  Google Scholar 

  15. S.H. Weerth, H. Rus, M.L. Shin, and C.S. Raine, Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis, Am J Pathol 163(3), 1069–1080 (2003).

    PubMed  CAS  Google Scholar 

  16. F.J. Seil, Tissue culture studies of demyelinating disease: a critical review, Ann Neurol 2(4), 345–355 (1977).

    Article  PubMed  CAS  Google Scholar 

  17. W. T. Liu, P. Vanguri, and M.L. Shin, Studies on demyelination in vitro: the requirement of membrane attack components of the complement system, J Immunol 131(2), 778–782 (1983).

    PubMed  CAS  Google Scholar 

  18. J.C. Cyong, S.S. Witkin, B. Rieger, E. Barbarese, R.A. Good, and N.K. Day, Antibody-independent complement activation by myelin via the classical complement pathway, J Exp Med 155(2), 587–598 (1982).

    Article  PubMed  CAS  Google Scholar 

  19. B.A. Silverman, P.F. Weller, and M.L. Shin, Effect of erythrocyte membrane modulation by lysolecithin on complement-mediated lysis, J Immunol 132(1), 386–391 (1984).

    PubMed  CAS  Google Scholar 

  20. P. Vanguri, and M.L. Shin, Activation of complement by myelin: identification of C1-binding proteins of human myelin from central nervous tissue, J Neurochem 46(5), 1535–1541 (1986).

    Article  PubMed  CAS  Google Scholar 

  21. N.J. Scolding, B.P. Morgan, A. Houston, A.K. Campbell, C. Linington, and D.A. Compston, Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies, J Neurol Sci 89(2–3), 289–300 (1989).

    Article  PubMed  CAS  Google Scholar 

  22. C. Linington, B.P. Morgan, N.J. Scolding, P. Wilkins, S. Piddlesden, and D.A. Compston, The role of complement in the pathogenesis of experimental allergic encephalomyelitis, Brain 112(4), 895–911 (1989).

    Article  PubMed  Google Scholar 

  23. S.J. Piddlesden, M.K. Storch, M. Hibbs, A.M. Freeman, H. Lassmann, and B.P. Morgan, Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. J Immunol 152(11), 5477–5484 (1994).

    PubMed  CAS  Google Scholar 

  24. S.J. Piddlesden, H. Lassmann, I. Laffafian, B.P. Morgan, and C. Linington, Antibody-mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation, Clin Exp Immunol 83(2), 245–250 (1991).

    Article  PubMed  CAS  Google Scholar 

  25. S.J. Piddlesden, H. Lassmann, F. Zimprich, B.P. Morgan, and C. Linington, The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 143(2), 555–564 (1993).

    PubMed  CAS  Google Scholar 

  26. S. Nataf, S.L. Carroll, R.A. Wetsel, A.J. Szalai, and S.R. Barnum, Attenuation of experimental autoimmune demyelination in complement-deficient mice, J. Immunol. 165(10), 5867–5873 (2000).

    PubMed  CAS  Google Scholar 

  27. D.M. Calida, C. Constantinescu, E. Purev, et al., Cutting edge: C3, a key component of complement activation, is not required for the development of myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in mice, J Immunol 166(2), 723–726 (2001).

    PubMed  CAS  Google Scholar 

  28. L. Boos, I.L. Campbell, R. Ames, R.A. Wetsel, and S.R. Barnum, Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis, J Immunol 173(7), 4708–4714 (2004).

    PubMed  CAS  Google Scholar 

  29. R. Reiman, C. Gerard, I.L. Campbell, and S.R. Barnum, Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis, Eur J Immunol 32(4), 1157–1163 (2002).

    Article  PubMed  CAS  Google Scholar 

  30. B.P. Morgan, M. Griffiths, H. Khanom, S.M. Taylor, and J.W. Neal, Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats, Clin Exp Immunol 138(3), 430–438 (2004).

    Article  PubMed  CAS  Google Scholar 

  31. R.J. Mead, S.K. Singhrao, J.W. Neal, H. Lassmann, and B.P. Morgan, The membrane attack complex of complement causes severe demyelination associated with acute axonal injury, J Immunol 168(1), 458–465 (2002).

    PubMed  CAS  Google Scholar 

  32. G.T. Tran, S.J. Hodgkinson, N. Carter, M. Killingsworth, S.T. Spicer, and B.M. Hall, Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, Pselectin expression, and cellular infiltrate in spinal cords, J Immunol 168(9), 4293–4300 (2002).

    PubMed  CAS  Google Scholar 

  33. L Soane, H. Rus, F. Niculescu, and M.L. Shin, Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation, J Immunol 163(11), 6132–6138 (1999).

    PubMed  CAS  Google Scholar 

  34. L. Soane, H.J. Cho, F. Niculescu, H. Rus, and M.L. Shin, C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway, J Immunol 167(4), 2305–2311 (2001).

    PubMed  CAS  Google Scholar 

  35. H. Rus, T. Jansen, C. Cudrici, J. Reed, M. Fosbrink, and F. Niculescu, C5b-9 terminal complement complex protects oligodendrocytes from apoptosis by regulating FLIP, FASEB J 18(5), A1159 (2004).

    Google Scholar 

  36. M.D. Esposti, The roles of Bid. Apoptosis 7(5), 433–440 (2002).

    Article  PubMed  CAS  Google Scholar 

  37. M. Thome, and J. Tschopp, Regulation of lymphocyte proliferation and death by FLIP, Nat Rev Immunol 1(1), 50–58 (2001).

    Article  PubMed  CAS  Google Scholar 

  38. T. Niculescu, S. Weerth, F. Niculescu, et al., Effects of Complement C5 on Apoptosis in Experimental Autoimmune Encephalomyelitis, J Immunol 172(9), 5702–5706 (2004).

    PubMed  CAS  Google Scholar 

  39. J. van Beek, M. van Meurs, B.A. t Hart, et al., Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation, J Immunol 174(4), 2353–2365 (2005).

    PubMed  Google Scholar 

  40. D.A. Compston, B.P. Morgan, A.K. Campbell, et al., Immunocytochemical localization of the terminal complement complex in multiple sclerosis. Neuropathol Appl Neurobiol, 15(4), 307–316 (1989).

    PubMed  CAS  Google Scholar 

  41. M.K. Storch, S. Piddlesden, M. Haltia, M. Iivanainen, B.P. Morgan, and H. Lassmann, Multiple sclerosis: in situ evidence for antibody-and complement-mediated demyelination. Ann Neurol 43(4), 465–471 (1998).

    Article  PubMed  CAS  Google Scholar 

  42. M.H. Barnett, and J.W. Prineas, Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion, Ann Neurol 55(4), 458–468 (2004).

    Article  PubMed  Google Scholar 

  43. B.P. Brink, R. Veerhuis, E.C. Breij, P. van der Valk, C.D. Dijkstra, and L. Bo, The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions, J Neuropathol Exp Neurol 64(2), 147–155 (2005).

    PubMed  CAS  Google Scholar 

  44. C. Lucchinetti, W. Bruck, J. Parisi, B. Scheithauer, M. Rodriguez, and H. Lassmann. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination, Ann Neurol 47(6), 707–717 (2000).

    Article  PubMed  CAS  Google Scholar 

  45. T.E. Mollnes, B. Vandvik, T. Lea, and F. Vartdal, Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex, J Neurol Sci 78(1), 17–28 (1987).

    Article  PubMed  CAS  Google Scholar 

  46. M.E. Sanders, E.L. Alexander, C.L. Koski, et al., Terminal complement complexes (SC5b-9) in cerebrospinal fluid in autoimmune nervous system diseases, Ann NY Acad Sci 540:387–388 (1988).

    Article  PubMed  CAS  Google Scholar 

  47. F. Sellebjerg, I. Jaliashvili, M. Christiansen, and P. Garred, Intrathecal activation of the complement system and disability in multiple sclerosis, J Neurol Sci 157(2), 168–174 (1998).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA

    Horea Rus & Cornelia Cudrici

  2. Multiple Sclerosis Center of Excellence, Veterans Administration Maryland Health Care System, Baltimore, MD, 21201, USA

    Horea Rus

  3. Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA

    Florin Niculescu

Authors
  1. Horea Rus
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  2. Cornelia Cudrici
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  3. Florin Niculescu
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Editors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, 19107

    John D. Lambris Ph.D. (Professor of Pathology & Laboratory Medicine) (Professor of Pathology & Laboratory Medicine)

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Rus, H., Cudrici, C., Niculescu, F. (2006). C5b-9 Complement Complex in Autoimmune Demyelination: Dual Role in Neuroinflammation and Neuroprotection. In: Lambris, J.D. (eds) Current Topics in Complement. Advances in Experimental Medicine and Biology, vol 586. Springer, Boston, MA. https://doi.org/10.1007/0-387-34134-X_10

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