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The Calcium Channel and the Transmitter Release Site

  • Chapter
Voltage-Gated Calcium Channels

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Summary

The Ca2+ channel exhibits multiple interactions at the presynaptic terminal. Not only is the channel critical for the action potential-gated influx of Ca2+ ions that leads to the activation of the transmitter release mechanism, a feed-forward pathway, but it is in itself modulated by a complex web of molecular interactions that involve both transmitter release site and non-release site proteins. Clearly, we do not yet nearly understand the full complexity of these molecular interactions since entirely new facets are being discovered apace. However, the picture is emerging of a highly structured and yet subtly designed molecular machine that is involved in complex forward and backward regulatory mechanisms in the control of transmitter release and, hence, of synaptic strength.

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  1. Cellular and Molecular Biology Division, Toronto Western Research Institute, Toronto, Ontario, Canada

    Elise F. Stanley & Allen W. Chan

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Stanley, E.F., Chan, A.W. (2005). The Calcium Channel and the Transmitter Release Site. In: Voltage-Gated Calcium Channels. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27526-6_8

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