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Voltage-Gated Calcium Channels

  • Gerald W. Zamponi

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Tashi G. Kinjo, Paul P. M. Schnetkamp
    Pages 1-11
  3. Sean J. Mulligan, Brian A. MacVicar
    Pages 12-26
  4. Richard W. Tsien, Curtis F. Barrett
    Pages 27-47
  5. William A. Catterall
    Pages 48-60
  6. Terrance P. Snutch, Jean Peloquin, Eleanor Mathews, John E. McRory
    Pages 61-94
  7. Thierry Cens, Sophie Restituito, Matthieu Rousset, Pierre Charnet
    Pages 95-112
  8. Stefan Herlitze, Melanie D. Mark
    Pages 113-140
  9. Elise F. Stanley, Allen W. Chan
    Pages 141-153
  10. Aparna Nirdosh, Gerald W. Zamponi
    Pages 154-167
  11. Roger A. Bannister, Ulises Meza, Brett A. Adams
    Pages 168-182
  12. Amy Lee, William A. Catterall
    Pages 183-193
  13. Mary T. An, Gerald W. Zamponi
    Pages 194-204
  14. Klaus J. F. Kepplinger, Christoph Romanin
    Pages 219-230
  15. Francesco Belardetti, Sian Spacey
    Pages 231-239
  16. Nancy M. Lorenzon, Kurt G. Beam
    Pages 240-261
  17. Jörg Striessnig, Jean-Charles Hoda, Edwin Wappl, Alexandra Koschak
    Pages 262-280
  18. Steffen Hering, Stanislav Sokolov, Stanislav Berjukow, Rainer Marksteiner, Eva Margreiter, Evgeni N. Timin
    Pages 281-293
  19. Christina I. Schroeder, Richard J. Lewis, David J. Adams
    Pages 294-308
  20. Stéphanie Barrère-Lemaire, Matteo E. Mangoni, Joël Nargeot
    Pages 309-325
  21. Emmanuel Bourinet, Philippe Lory, Jean Chemin, Steve Dubel, Régis Lambert, Olivier Poirot et al.
    Pages 326-333
  22. Melanie E. M. Kelly, Steven Barnes
    Pages 334-345
  23. Back Matter
    Pages 373-377

About this book

Introduction

oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar­ macological targets in the treatment of a variety of disorders, such as epi­ lepsy, hypertension, and pain. Voltage-gated calcium channels have there­ fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl­ edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac­ tivity, the book delves into a provocative overview of the history of the cal­ cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat­ ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.

Keywords

Activation Biophysics Peptide cardiovascular distribution genes physiology regulation

Authors and affiliations

  • Gerald W. Zamponi
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of CalgaryCalgaryCanada

Bibliographic information