Abstract
The main cause of death in coronary artery disease (CAD)is the rupture of unstable or “vulnerable” atherosclerotic plaque which leads to a sudden occlusion. The structure and composition of an atherosclerotic plaque is an important determinant in its stability. Vulnerable plaque tend to have a thin fibrous cap and a large lipid core and are softer and more likely to rupture than more stable plaque with thicker caps.Currently, a great deal of research is ongoing to investigate different imaging techniques to differentiate stable and vulnerable plaque. The technique could significantly enhance the screening and management of patients with CAD. It would have great potential in identifying patients who are at a high risk for acute events.
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References
F.G. Blankenberg, P.D. Katsikis, J.F. Tait, R.E. Davis, L. Naumovski, K. Ohtsuki, S. Kopiwoda, M.J. Abrams, M. Darkes, R.C. Robbins, H.T. Maecker, and H.W. Strauss, “In vivo detection and imaging of phosphatidylserine expression during programmed cell death,” Proc. Natl. Acad. Sci., vol. 95, pp. 6349–6354, 1998.
F.G. Blankenberg and H.W. Strauss, “Noninvasive strategies to image cardiovascular apoptosis,” Cardiovascular Disease, vol. 19, pp. 165–172, 2001.
N. Maeda, H. Hagihara, Y. Nakata, S. Hiller, J. Wilder, and R. Reddick, “Aortic wall damage inmice unable to synthesize ascorbic acid,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, pp. 841–846, 2000.
Y. Nakata and N. Maeda, “Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic acid,” Circulation, vol. 105, pp. 1485–1490, 2002.
W.P. Segars, B.W.M. Tsui, E.C. Frey, and G.A. Johnson, “Development of a 4D digital mouse phantom for molecular imaging research,” Molecular Imaging and Biology, vol. 5, no. 3 pp. 126–127, 2003.
J.F. Tait, D.S. Brown, D.F. Gibson, F.G. Blankenberg, and H.W. Strauss, “Development and characterization of annexin Vmutants with endogenous chelation sites for 99mTc,” Bioconjugate Chemistry, vol. 11, pp. 918–925, 2000.
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Segars, W.P., Wang, Y., Tsui, B.M.W. (2005). Effect of Respiratory Motion on Plaque Imaging in the Mouse Using Tc-99m Labeled Annexin-V. In: Kupinski, M.A., Barrett, H.H. (eds) Small-Animal Spect Imaging. Springer, Boston, MA. https://doi.org/10.1007/0-387-25294-0_16
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DOI: https://doi.org/10.1007/0-387-25294-0_16
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