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Tissue Engineering Skeletal Muscle

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Functional Tissue Engineering

Conclusion

In vitro tissue engineering of skeletal muscle involves culturing myogenic cells in an environment that emulates the in vivo environment so that the cells proliferate, fuse, organize in three dimensions, and differentiate into functional skeletal muscle. The tissue engineer uses a multitude of in vitro environmental cues to direct the proliferation process. The end result will be a skeletal muscle construct that resembles skeletal muscle in both form and function. The construct will be organized like a skeletal muscle, with long multinucleated cells oriented parallel to its long axis, and the construct will be capable of generating useful directed force and power. Such constructs have been developed from avian, rodent, and human primary muscle cells as well as immortalized myogenic cells. Measurements and characterization of the construct’s biochemical and contractile functions have begun. Use of these early generation constructs for basic science research, as implantable therapeutic protein delivery devices, and as drug screening constructs are moving forward. Skeletal muscle constructs will likely be implanted into humans as sources of secreted proteins in the near future, and will no doubt one day replace muscle contractile function in patients with functional deficits in force and power generation.

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Authors
  1. Paul E. Kosnik
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  2. Robert G. Dennis
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  3. Herman H. Vandenburgh
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Editors and Affiliations

  1. Orthopaedic Research Laboratories Department of Surgery 375 MSRB, Duke University Medical Center, Box 3093, Durham, NC, 22710, USA

    Farshid Guilak

  2. Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, Cincinnati, OH, 45221-0048, USA

    David L. Butler

  3. Orthopaedic Research Laboratories, University of Michigan, Room G-161, 400 North Ingalls, Ann Arbor, MI, 48105-0486, USA

    Steven A. Goldstein

  4. Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA

    David J. Mooney

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Kosnik, P.E., Dennis, R.G., Vandenburgh, H.H. (2003). Tissue Engineering Skeletal Muscle. In: Guilak, F., Butler, D.L., Goldstein, S.A., Mooney, D.J. (eds) Functional Tissue Engineering. Springer, New York, NY. https://doi.org/10.1007/0-387-21547-6_28

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