Functional Tissue Engineering

  • Farshid Guilak
  • David L. Butler
  • Steven A. Goldstein
  • David J. Mooney

Table of contents

  1. Front Matter
    Pages i-xvi
  2. The Functional Properties of Native Tissues

    1. Front Matter
      Pages 1-1
    2. Stephen C. Cowin
      Pages 3-16
    3. Savio L-Y. Woo, Steven D. Abramowitch, John C. Loh, Volker Musahl, James H-C. Wang
      Pages 17-34
    4. Gerard A. Ateshian, Clark T. Hung
      Pages 46-68
  3. Functional Requirements of Engineered Tissues

  4. Design Parameters for Tissue Engineering

    1. Front Matter
      Pages 127-127
    2. Michael V. Sefton, Robert Akins
      Pages 139-145
    3. Robert E. Guldberg, Angel O. Duty
      Pages 146-161
    4. Stephen M. Klisch, Michael A. DiMicco, Anne Hoger, Robert L. Sah
      Pages 194-210
  5. Assessment of Junction in Engineered Tissues

    1. Front Matter
      Pages 211-211
    2. David L. Butler, Matthew Dressler, Hani Awad
      Pages 213-226
    3. Jethy C. Y. Hu, Kyriacos A. Athanasiou
      Pages 227-242
    4. David N. Ku, Hai-Chao Han
      Pages 258-267
    5. R. J. O’Keefe, S. Totterman, E. M. Schwarz, J. M. Looney, G. S. Seo, J. Tamez-Pena et al.
      Pages 268-274
  6. Cell-Matrix Interactions in Functional Tissue Engineering

    1. Front Matter
      Pages 275-275
    2. Craig A. Simmons, David J. Mooney
      Pages 291-304
    3. Robert T. Tranquillo, Brett C. Isenberg
      Pages 305-317
    4. Albert J. Banes, Michelle Wall, Joanne Garvin, Joanne Archambault
      Pages 318-334
  7. Bioreactors and the Role of Biophysical Stimuli in Tissue Engineering

    1. Front Matter
      Pages 335-335
    2. François A. Auger, Guillaume Grenier, Marielle R’emy-Zolghadri, Lucie Germain
      Pages 347-359
    3. Lisa E. Freed, Maria A. Rupnick, Dirk Schaefer, Gordana Vunjak-Novakovic
      Pages 360-376
    4. Paul E. Kosnik, Robert G. Dennis, Herman H. Vandenburgh
      Pages 377-392
  8. Regulatory and Clinical Tissues in Tissue Engineering

    1. Front Matter
      Pages 393-393
    2. Edith Richmond Schwartz
      Pages 400-404
  9. Back Matter
    Pages 405-426

About this book



The goal of "tissue engineering" is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology.

Despite its early successes, however, tissue engineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. This book addresses and discusses a number of issues that need to be addressed in order for tissue engineers to effectively repair or replace these load-bearing structures. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Which of these properties should a tissue engineer insist upon incorporating into the design? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ in order to be successful? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome?

Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology in functional tissue engineering. The book will be useful to students and researchers as it will increase awareness among tissue engineers of the importance of restoring "function" when engineering tissue constructs, and identifying the critical structural and mechanical requirements needed for each construct. It will also provide an invaluable source of information to help tissue engineers incorporate these functional criteria into the design, manufacture, and optimization of tissue engineered products. Finally it serves as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering.


DNA biology biomechanics bone cell cells gene therapy implant molecular biology protein proteins stress surgery tissue tissue engineering

Editors and affiliations

  • Farshid Guilak
    • 1
  • David L. Butler
    • 2
  • Steven A. Goldstein
    • 3
  • David J. Mooney
    • 4
  1. 1.Orthopaedic Research Laboratories Department of Surgery 375 MSRBDuke University Medical CenterDurhamUSA
  2. 2.Department of Biomedical EngineeringUniversity of CincinnatiCincinnatiUSA
  3. 3.Orthopaedic Research LaboratoriesUniversity of MichiganAnn ArborUSA
  4. 4.Department of Biologic and Materials SciencesUniversity of MichiganAnn ArborUSA

Bibliographic information