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References
Agarwal D. P. and Goedde H. W., Pharmacogenetics of alcohol dehydrogenase, in W. Kalow (ed.), Pharmacogenetics of Drug Metabolism, Pergamon, New York, 1992, pp. 263–280.
Agrawal A. K. and Shapiro B. H., Gender, age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms, Drug Metab. Dispos. 25: 1249–1256, 1997.
Baijal P. K. and Fitzpatrick D. W., Effect of dietary protein on hepatic and extrahepatic phase I and phase II drug metabolizing enzymes, Toxicol. Lett. 89: 99–106, 1996.
Barry M. and Feely J., Enzyme induction and inhibition, Pharmacol. Ther. 48: 71–94, 1990.
Beaune P. et al., Comparison of monooxygenase activities and cytochrome P450 isozyme concentrations in human liver microsomes, Drug Metab. Dispos. 14: 437–442 1986.
Benedetti M. S. and Tipton K. F., Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics, J. Neural. Transm. 52: 149–171, 1998.
Bertilsson, L., Geographycal/interracial differences in polymorphic drug oxidation, current state of knowledge of cytochrome P450 (CYP) 2D6 and 2C19, Clin. Pharmacokinet. 29: 192–209, 1995.
Birkett D. J. et al., in vitro approaches can predict human drug metabolism, Trends Pharmacol. Sci. 14: 292–294, 1993.
Bourri&é M. et al., Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes, J. Pharmacol. Exp. Ther. 277: 321–332, 1996.
Burchell B. and Coughtrie M. W. H., UDP-glucuronosyl transferases, Pharmacol. Ther. 43: 261–289, 1989.
Burchell B. et al., Specificity of human UDP-glucuronosyl transferases and xenobiotic glucuronidation, Life Sci. 57: 1819–1831, 1995.
Caldwell J. et al., An introduction to drug disposition: the basic principles of absorption, distribution, metabolism and excretion, Toxicol. Pathol. 23: 102–114, 1995.
Cashman J. R., Structural and catalytic properties of the mammalian flavin-containing monooxygenase, Chem. Res. Toxicol. 8: 166–181, 1995.
Chauret N. et al., Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes, Drug Metab. Dispos. 26: 1–4, 1998.
Clarke D. J. and Burchell B., The uridine diphosphate glucuronosyltransferase multigene family: function and regulation, in F. C. Kauffman (ed.), Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, Springer-Verlag, New York, 1994, pp. 3–43.
Connelly J. C. and Bridges J. W., The distribution and role of cytochrome P450 in extrahepatic organs, in J. W. Bridges and L. F. Chasseaud (eds.), Progress in Drug Metabolism, Vol. 5, John Wiley & Sons, Chichester, 1980, pp. 1–112.
Coughtrie M. W. H. et al., Biology and function of the reversible sulfation pathway catalyzed by human sulfotransferases and sulfatases, Chem. Biol. Interact. 109: 3–27, 1998.
Daly A. K. et al., Metabolic polymorphisms, Pharmac. Ther. 57: 129–160, 1993.
Daly A. K., Molecular basis of polymorphic drug metabolism, J. Mol. Med. 73: 539–553, 1995.
DeGroot M. J. and Vermeulen N. P. E., Modeling the active site of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes, Drug Metab. Rev. 29: 747–799, 1997.
de Kanter R. et al., A rapid and simple method for cryopreservation of human liver slices, Xenobiotics 28: 225–234, 1998.
de Waziers L. et al., Cytochrome P450 isoenzymes, epoxide hydrolase glutathione transferases in rat and human hepatic and extrahepatic tissues, J. Pharmacol. Exp. Ther. 253: 387–394, 1990.
Ekins S., Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism, Drug Metab. Rev. 28: 591–623, 1996.
Gelbonin H. V., Cytochrome P450 and monoclonal antibodies, Pharmacol. Rev. 45: 413–453, 1993.
George J. et al., Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver diseases, Hepatology 21: 120–128, 1995.
Gleiter C. H. and Gundert-Remy U., Gender differences in pharmacokinetics, E. J. Metab. Pharmacokinet. 21: 123–128, 1996.
Goedde H. W. and Agarwal D. P., Pharmacogenetics of aldehyde dehydrogenase, in W. Kalow (ed.), Pharmacogenetics of Drug Metabolism, Pergamon, New York, 1992, pp. 281–311.
Gonzalez F. J., Human cytochrome P450 problems and prospects, Trends Pharmacol. Sci. 13: 346–352, 1992
Guder W. G. and Ross B. D., Enzyme distribution along the nephron, Kidney Int. 26: 101–111, 1984.
Guengerich F. P., Influence of nutrients and other dietary materials on cytochrome P-450 enzymes, Am. J. Clin. Nutr. 61 (Suppl): 651S–658S, 1995.
Guengerich F. P., in vitro techniques for studying drug metabolism, J. Pharmacokinet. Biopharm. 24: 521–533, 1996.
Guengerich F. P. et al., New applications of bacterial systems to problems intoxicology, Crit.Rev. 551–583, 1996.
Halpert J. R. et al., Contemporary issues in toxicology: selective inhibitors of cytochromes P450, Toxicol. Appl. Pharmacol. 125: 163–175, 1994.
Harris R. Z. et al., Gender effects in pharmacokinetics and pharmacodynamics, Drugs 50: 222–239, 1995.
Hawksworth G. M., Advantages and disadvantages of using human cells for pharmacological and toxicological studies, Human Exp. Toxicol. 13: 568–573, 1994.
Hayball P. J., Formation and reactivity of acyl glucuronides: the influence of chirality, Chirality 7: 1–9, 1995.
Ilett K. F. et al., Metabolism of drugs and other xenobiotics in the gut lumen and wall, Pharmacol. Ther. 46: 67–93, 1990.
Kaminsky L. S. and Fasco M. J., Small intestinal cytochromes P450, Crit. Rev Toxicol. 21: 407–422, 1992.
Kaspersen F. M. and Van Boeckel C. A. A,, A review of the methods of chemical synthesis of sulphate and glucuronide conjugates, Xenobiotica 17: 1451–1471, 1987.
Kauffman F. C., Regulation of drug conjugate production by futile cycling in intact cells, in F. C. Kauffman (ed.), Conjugation-Deconjugation Reactions in Drug Metabolism andToxicity, Springer-Verlag, New York, 1994, pp. 247–255.
Kawalek J. C. and Andrews A. W., The effect of solvents on drug metabolism in vitro, Drug Metab. Dispos. 8: 380–384, 1980.
Krishna D. R. and Klotz U., Extrahepatic metabolism of drugs in humans, Clin. Pharmacokinet. 26: 144–160, 1994.
Lohr J. W. et al., Renal drug metabolism, Pharmacol. Rev. 50: 107–141, 1998.
Meyer U. A,, Overview of enzymes of drug metabolism, J. Pharmacokinet. Biopharm. 24(5):449–459, 1996.
Mugford C. A. and Kedderis G. L., Sex-dependent metabolism of xenobiotics, Drug Metab. Rev. 30: 441–498, 1998.
Mugford C. A. et al., 1-Aminobenzotirazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats. Fund. Appl. Toxicol. 19: 43–49, 1992.
Mulder G. J., Glucuronidation and its role in regulation of biological activity of drugs, Ann. Rev. Pharmacol. Toxicol. 32: 25–49, 1992.
Musson D. G. et al., Assay methodology for quantitation of the ester and ether glucuronide conjugates of difflunisal in human urine, J. Chromatogr. 337: 363–378, 1985.
Nedelcheva V. and Gut I., P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer, Xenobiotica 24: 1151–1175, 1994.
Nelson D. R., P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics 6: 1–42, 1996.
Newton D. J. et al., Cytochrome P450 inhibitors: evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes, Drug Metab. Dispos. 23: 154–158, 1995.
Okey A. B., Enzyme induction in the cytochrome P-450 system, Pharmacol. Ther. 45: 241–298, 1990.
O’Mahony M. S. and Woodhouse K. W., Age, environmental factors and drug metabolism, Pharmacol. Ther. 61: 279–287, 1994.
Park B. K., in vivo methods to study enzyme induction and enzyme inhibition, Pharmacol. Ther. 33: 109–113, 1987.
Parkinson A,, Biotransformation of xenobiotics, in C. D. Klaassen (ed.), Casarett & Doull’s Toxicology: The Basic Science of Poisons, 5th Ed., McGraw-Hill, New York, 1996a, pp. 113–186.
Parkinson A,, An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials, Toxicol. Pathol. 24: 45–57, 1996b.
Pearce R. E. et al., Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity, Arch. Biochem. Biophys. 331: 145–169, 1996.
Perrier D. et al., Effect of product inhibition on kinetics of drug elimination, J. Pharmacokinet. Biopharm. 1: 231–242, 1973.
Price R. J. et al., Influence of slice thickness and culture conditions on the metabolism of 7-ethoxycoumarin in precision-cut rat liver slices, ATLA 26: 541–548, 1998.
Ravindranath V. and Boyd M. R., Xenobiotic metabolism in brain, Drug Metab. Rev. 27: 419–448, 1995.
Remmel R. P. and Burchell B., Validation and use of cloned, expressed human drug-metabolizing enzymesms in heterologous cells for analysis of drug metabolism and drug-drug interactions, Biochem. Pharmacol. 46: 559–566, 1993.
Rendic S. and DiCarlo F. J., Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors, Drug Metab. Rev. 29: 413–580, 1997.
Rodrigues A. D., Use of in vitro human metabolism studies in drug development: an industrial perspective, Biochem. Pharmacol. 48: 2147–2156, 1994.
Satoh T. and Hosokawa M., The mammalian carboxyesterases: from molecules to functions, Ann. Rev. Pharmacol. Toxicol. 38: 257–288, 1998.
Schwenk M., Mucosal biotransformation, Toxicol. Pathol. 16: 138–146, 1988.
Shimada T. et al., Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians, J. Pharmacol. Exp. Ther. 210: 414–422, 1994.
Shimojo N., Cytochrome P450 changes in rats with streptozocin-induced diabetes, Int. J. Biochem. 26: 1261–1268, 1994.
Silva J. M. et al., Refinement of an in vitro cell model for cytochrome P450 induction, Drug Metab. Dispos. 26: 490–496, 1998.
Skett P., Biochemical basis of sex differences in drug metabolism, Pharmacol. Ther. 38: 269–304, 1988.
Skett P., Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-solutions, in Vitro Toxicol. 8: 491–504, 1994.
Smith C. A. D. et al., Genetic polymorphisms in xenobiotic metabolism, Eur. J. Cancer 30A: 1921–1935, 1994.
Smith D. A., Species differences in metabolism and pharmacokinetics: are we close to an understanding? Drug Metab. Rev. 23: 355–373, 1991.
Smith D. A. and Jones B. C., Speculations on the substrate structural-activityrelationships (SSAR) of cytochrome P450 enzymes, Biochem. Pharmacol. 44: 2089–2098, 1992.
Smith D. A., Chemistry and enzymology: their use in the prediction of human drug metabolism, Eur. J. Pharm. Sci. 2: 69–11, 1994a.
Smith D. A., Design of drugs through a consideration of drug metabolism and pharmacokinetics, Eur. J. Drug Metab. Pharmacokinet. 3: 193–199, 19946.
Smith P. C. et al., Irreversible binding of Zomepirac to plasma protein in vitro and in vivo, J. Clin. Invest. 77: 934–939, 1986.
Soucek P. and Gut I., Cytochromes P450 in rats: structure, functions, properties and relevant human forms, Xenobiotica 22: 83–103, 1992.
Thummel K. E., Use of midazolam as a human cytochrome P450 3A probe: II characterization of inter-and intraindividual hepatic CYP3A variability after liver transplantation, J. Pharmacol. Exp. Ther. 271: 557–566, 1994.
van der Aar E. M. et al., Strategies to characterize the mechanisms of action and the active sites of glutathione S-transferases: a review, Drug Metab. Rev. 30: 569–643, 1998.
Vatsis K. P. and Weber W. W., Human N-acetyltransferases, in F. C. Kauffman (ed.), Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, Springer-Verlag, New York, 1994, pp. 109–130.
Vickers A. E. M., Liver slices: an in vitro tool to predict drug biotransformation and to support risk assessment, In Vitro Toxicol. 10: 71–80, 1997.
Watt J. A. et al., Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat, Xenobiotica 2: 403–415, 1991.
Weinshilboum S. and Aksoy I., Sulfation pharmacogenetics in humans, Chem. Biol. Interact. 92: 233–246, 1994.
Weinshilboum S. and Otterness D., Sulfotransferase enzymes, in F. C. Kauffman (ed.), Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity, Springer-Verlag, New York, 1994, pp. 45–78.
Williams F. M., Serum enzymes of drug metabolism, Pharmacol. Ther. 34: 99–109, 1987.
Williams L. et al., The influence of food on the absorption and metabolism of drugs: an update, E. J. Drug Metab. Pharmacokinet. 21: 201–211, 1996.
Wrighton S. A. and Stevens J. C., The human hepatic cytochrome P450 involved in drug metabolism, Crit. Rev. Toxicol. 22: 1–21, 1992.
Wrighton S. A. et al., in vitro methods for assessing human hepatic drug metabolism: their use in drug development, Drug Metab. Rev. 25: 453–484, 1993.
Zhang Q-Y. et al., Characterization of rat small intestinal cytochrome P450 composition and inducibility, Drug Metab. Dispos. 24: 322–328, 1996.
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(2002). Metabolism. In: Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Springer, Boston, MA. https://doi.org/10.1007/0-306-46820-4_8
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