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Hyperbaric Oxygen Therapy in the Management of Severe Soft Tissue Injuries

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Hyperbaric Oxygenation Therapy

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Abstract

Crush injuries are still challenging injuries to treat, despite improvements in therapeutic strategies and procedures. The pathophysiology of crush injuries has two important clinical aspects: problem wound and infection. Based on previous studies and practices, hyperbaric oxygen therapy (HBO2 therapy) has been used for both problem wounds and infectious diseases, so the use of HBO2 therapy for crush injuries should be considered as a therapeutic option.

In this chapter, we first introduce the wound healing process and the role of oxygen. Second, we discuss the pathophysiology of crush injuries and the relationship between HBO2 therapy and crush injuries. In addition, we discuss clinical settings and review the previous clinical experience in this field.

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Abbreviations

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

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Acknowledgments

The main author N.Y. wrote this manuscript during a research program in the UK. We appreciate the support provided by Professor Christoph Thiemermann and his team at the Centre for Translational Medicine and Therapeutics, the William Harvey Research Institute, Queen Mary University of London. I also thank Ms. Nurini and Mr. Cesare Colloura for making the best environment in the UK.

Author contributions:

N. Y.: Writing the main text, reviewing previous studies

I. T.: Reviewing previous studies and supervising

S. O.: Reviewing previous studies and supervising

Author information

Authors and Affiliations

  1. Hyperbaric Oxygenation Therapy Team, Gifu University Hospital Advanced Critical Care Centre, Gifu, Japan

    Noriaki Yamada

  2. Critical Care Center, Gifu Prefectural General Medical Center, Gifu, Japan

    Izumi Toyoda

  3. Hyperbaric Oxygenation Therapy Team, Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

    Shinji Ogura

Authors
  1. Noriaki Yamada
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  2. Izumi Toyoda
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  3. Shinji Ogura
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Corresponding author

Correspondence to Noriaki Yamada .

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Editors and Affiliations

  1. Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan

    Nariyoshi Shinomiya

  2. Hakodate Shintoshi Hospital, Hakodate, Hokkaido, Japan

    Yasufumi Asai

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Yamada, N., Toyoda, I., Ogura, S. (2020). Hyperbaric Oxygen Therapy in the Management of Severe Soft Tissue Injuries. In: Shinomiya, N., Asai, Y. (eds) Hyperbaric Oxygenation Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-13-7836-2_6

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  • DOI: https://doi.org/10.1007/978-981-13-7836-2_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-7835-5

  • Online ISBN: 978-981-13-7836-2

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