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Prospective Advances in Circular RNA Investigation

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Circular RNAs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1087))

Abstract

circRNAs have emerged as one of the key regulators in many cellular mechanisms and pathogenesis of diseases. However, with the limited knowledge and current technologies for circRNA investigations, there are several challenges that need to be addressed for. These include challenges in understanding the regulation of circRNA biogenesis, experimental designs, and sample preparations to characterize the circRNAs in diseases as well as the bioinformatics pipelines and algorithms. In this chapter, we discussed the above challenges and possible strategies to overcome those limitations. We also addressed the differences between the existing applications and technologies to study the circRNAs in diseases. By addressing these challenges, further understanding of circRNAs roles and regulations as well as the discovery of novel circRNAs could be achieved.

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Authors and Affiliations

  1. Universiti Kebangsaan Malaysia (UKM) Medical Molecular Biology Institute (UMBI), Kuala Lumpur, Malaysia

    Siti Aishah Sulaiman, Nor Azian Abdul Murad, Ezanee Azlina Mohamad Hanif, Nadiah Abu & Rahman Jamal

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  1. Siti Aishah Sulaiman
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  2. Nor Azian Abdul Murad
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  3. Ezanee Azlina Mohamad Hanif
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  4. Nadiah Abu
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  5. Rahman Jamal
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Correspondence to Nor Azian Abdul Murad or Nadiah Abu .

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  1. School of Life Science, Institute of Cardiovascular Sciences, Shanghai University, Shanghai, China

    Junjie Xiao

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Sulaiman, S.A., Abdul Murad, N.A., Mohamad Hanif, E.A., Abu, N., Jamal, R. (2018). Prospective Advances in Circular RNA Investigation. In: Xiao, J. (eds) Circular RNAs. Advances in Experimental Medicine and Biology, vol 1087. Springer, Singapore. https://doi.org/10.1007/978-981-13-1426-1_28

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