Zusammenfassung
Die Annahme, daβ oxidativer Streβ im Rahmen der Ätiopathogenese der Alzheimer Krankheit (DAT) eine wichtige Rolle spielen könnte, wird heute als vergleichsweise gut abgesicherte Hypothese angesehen. Man knüpft dabei an überlegungen an, die im Zusammenhang mit natürlichen Alterungsvorgängen und anderen neurodegenerativen Krankheiten schon intensiv erörtert worden sind. Besonders bei der Parkinsonschen Krankheit oder der amyotrophen Lateralsklerose wird dem Modell des neuronalen Zellunterganges durch oxidativen Streβ erhebliche Bedeutung zugesprochen (Hal-Liwell 1992, Jenner 1994, Frölich und Riederer 1995).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Agnoli A, Martucci N, Fabbrini G, Buckley A, Fioravanti M (1990) Monoamine oxidase and dementia: treatment with an inhibitor of MAOB activity. Dementia 1: 109–114
Agnoli A, Fabbrini G, Fioravanti M, Martucci N (1992) CBF and cognitive evaluation of Alzheimer type patients before and after IMAOB treatment: a pilot study. Eur Neuropharmacol 2: 31–35
Bell J, Beglan C, London E (1996) Interaction of ascorbic acid with the neurotoxic effects of NMDA and sodium nitroprusside. Life Sci 58: 367–371
Bergamasco B, Scarzella L, La Commare P (1994) Idebenone, a new drug in the treatment of cognitive impairment in patients with senile dementia of the Alzheimer type. Funct Neurol 9: 161–168
Blum-Degen D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P (1995) Interleukin-1 bete and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients. Neurosci Lett 202: 17–20
Bruno V, Battaglia G, Copani A, Sortino MA, Canonico PL, Nicoletti F (1994) Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons. Neurosci Lett 178: 193–196
Burke W, Ranno A, Roccaforte W, Wengel S, Bayer B, Willcockson N (1993a) L-deprenyl in the treatment of mild dementia of the Alzheimer type: preliminary results. J Am Geriatr Soc 41: 367–370
Burke W, Roccaforte W, Wengel S, Bayer B, Ranno A, Willcockson N (1993b) L-deprenyl in the treatment of mild dementia of the Alzheimer type: results of a 15-month trial. J Am Geriatr Soc 41: 1219–1225
Burns A, Marsh A, Bender D (1989) A trial of vitamin supplementation in senile dementia. Int J Ger Psychiat 4: 333–338
Burton G, Ingold K (1989) Vitamin E as an in vitro and vivo antioxidant. Ann NY Acad Sci 570: 7–21
Butterfield DA (1996) Commentary: Alzheimer’s disease: a disorder of oxidative stress. Alzheimer’s Dis Rev 1: 68–70
Campi N, Todeschini GP, Scarzella L (1990) Selegiline versus 1-acetylcarnitine in the treatment of Alzheimer-type dementia. Clin Ther 12: 306–314
Dickson DW (1996) Commentary: Glycoxidation in Alzheimer’s disease: a specific mechanism of early lesion pathogenesis? Alzheimer’s Dis Rev 1: 75–76
Falsaperla A, Monici Preti PA, Oliani C (1990) Selegiline versus oxiracetam in patients with Alzheimer’s type dementia. Clin Ther 12: 376–384
Fahn S (1992) A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson’s disease. Ann Neurol 32: 128–132
Finali G, Piccirilli M, Oliani C, Piccinin GL (1991) L-deprenyl therapy improves verbal memory in amnestic Alzheimer patients. Clin Neuropharmacol 14: 523–536
Finali G, Piccirilli M, Oliani C, Piccinin GL (1992) Alzheimer-type dementia and verbal memory performance: influence of selegiline therapy. Ital J Neurol Sci 13: 141–148
Fischer P, Götz ME, Danielczyk W, Gsell W, Riederer P (1997) Blood transferrin and ferritin in Alzheimer’s disease. Life Sci 60: 2273–2278
Frei B, England L, Ames B (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci 86: 6377–6381
Frölich L, Riederer P (1995) Free radical mechanisms in dementia of Alzheimer type and the potential for antioxidative treatment. Drug Res 45: 443–446
Gerlach M, Riederer P, Youdim MBH (1995) Neuroprotective therapeutic strategies. Biochem Pharmacol 50: 1–16
Gillis JC, Benfield P, Mctavish D (1994) Ide-benone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders. Drugs and Aging 5: 133–152
Goad DL, Davis CM, Liem P, Fuselier CC, McCormack JR, Olsen KM (1991) The use of selegiline in Alzheimer’s patients with behavior problems. J Clin Psychiat 52: 342–345
Götz ME, Fischer P, Gsell W, Riederer P, Streifler M, Simanyi M, Müller F, Danielczyk W (1998) Platelet monoamine oxidase B activity in dementia: a 4 year follow up. Dem Geriatr Cogn Disord 9: 74–77
Gsell W, Conrad R, Hickethier M, Sofic E, Frölich L, Wichart I, Jellinger K, Moll G, Ransmeyr G, Beckmann H, Riederer P (1995) Decreased catalase activity in brains of patients with dementia of Alzheimer type. J Neurochem 64: 1216–1223
Halliwell B (1992) Reactive oxygen species and the central nervous system. J Neurochem 59: 1609–1623
Hofferberth B (1994) The efficacy of Egb 761 in patients with senile dementia of the Alzheimer type, a double blind, placebo-controlled study on different levels of investigation. Hum Psychopharmacol 9: 215–222
Hoyer S (1997) Biochemie des alternden Hirnes. In: Rösler M, Retz W, Thome J (Hrsg) Die Alzheimer Krankheit. Beltz, Deutscher Studien Verlag, Weinheim
Ihl R, Perisic I, Maurer K, Dierks T (1989) Effect of 3 months treatment with tenilsetam in patients suffering from dementia of Alzheimer type (DAT). J Neural Transm [PD-Sect] 1: 84–85
Jenner P (1994) Oxidative damage in neurodegenerative disease. Lancet 344: 796–798
Kanowski S, Herrmann WM, Staphan K, Wierich W, Hörr R (1996) Proof of efficacy of the Ginkgo biloba special extract Egb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multiinfarct dementia. Pharmacopsychiatry 29: 47–56
Koutsilieri E, O’Callaghan JF, Chen TS, Riederer P, Rausch WD (1994) Selegiline enhances survival and neurite outgrowth of MPP+-treated dopaminergic neurons. Eur J Pharmacol 269: R3–R4
Lawlor B, Aisen P, Green C, Fine E, Schmeidler J (1997) Selegiline in the treatment of behavioural disturbance in Alzheimer’s disease. Int J Ger Psychiat 12: 319–322
Mangoni A, Grassi MP, Frattola L, Piolti R, Bassi S, Motta A, Marcone A, Smirne S (1991) Effects of a MAO-B inhibitor in the treatment of Alzheimer’s disease. Eur Neurol 31: 100–107
Martignoni E, Bono G, Blandini F, Sinforiani E, Merlo P, Nappi G (1991) Monoamines and related metabolite levels in the cerebrospinal fluid of patients with dementia of Alzheimer’s type. Influence of treatment with 1-deprenyl. J Neural Transm [PD-Sect] 3: 15–25
Mattson M (1997) Central role of oxyradicals in the mechanism of amyloid β-peptide cytotoxicity. Alzheimer’s Dis Rev 2: 1–14
Meydani M (1995) Vitamin E. Lancet 345: 170–174
Monteverde A, Gnemmi P, Rossi F, Monteverde A (1990) Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin Ther 12: 315–322
Münch G, Taneli Y, Schraven E, Schindler U, Schinzel R, Palm D, Riederer P (1994) The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylate. J Neural Transm [PD-Sect] 8: 193–208
Münch G, Simm A, Double KL, Riederer P (1996) Commentary: Oxidative stress and advanced glycation endproducts-parts of a vicious circle of neurodegeneration. Alzheimer’s Dis Rev 1: 71–74
Nitta A, Murakami Y, Furukawa Y, Kawatsura W, Hayashi K, Yamada K, Hasegawa T, Nabeshima T (1994) Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basa forebrain-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol 349: 410–407
Parkinson Study Group (1993) Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. N Engl J Med 328: 176–183
Parnetti L (1995) Clinical pharmacokinetics of drugs for Alzheimer’s disease. Clin Pharmacokinet 29: 110–129
Parnetti L, Ambrosoli L, Abate G, Azzini C, Balestreri R, Bordin A, Crepaldi G, Christiani G, Cucinotta D (1995) Posatireline for the treatment of late onset Alzheimer’s disease: a double-blind multicentre study vs citicoline and ascorpic acid. Acta Neurol Scand 92: 135–140
Peyser CE, Folstein M, Chase GA, Starkstein S, Brandt J, Cockrell JR, Bylsma F, Coyle JT, Mchugh PR, Folstein SE (1995) Trial of d-α-Tocopherol in Huntington’s disease. Am J Psychiatry 152: 1771–1775
Piccinin GL, Final G, Piccirilli M (1990) Neuropsychological effects of 1-deprenyl in Alzheimer’s type dementia. Clin Neuropharmacol 13: 147–163
Rösler M, Retz W, Thome J, Riederer P (1998) Free radicals in Alzheimer’s dementia: currently available theraeutic strategies. J Neural Transm [Suppl] 53: 211–219
Sano M, Ernesto C, Thomas R, Klauber M, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman C, Pfeifer E, Schneider L, Thal L (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. N Engl J Med 336: 1216–1222
Schneider L, Pollo V, Zemansky M, Gleason R, Palmer R, Sloane B (1991) A pilot study of lowdose 1-deprenyl in Alzheimer’s disease. J Ger Psychiat Neurol 4: 143–148
Schneider L, Olin J, Pawluczyk S (1993) A double-blind crossover pilot study of 1-deprenyl (selegiline) combined with Cholinesterase inhibitor in Alzheimer’s disease. Am J Psychiatry 150: 321–323
Senin U, Parnetti L, Barbagallo-Sangiorgi G, Bartorelli L, Bocola V, Capurso A, Cuzzupoli M, Denaro M, Margliano V, Tammaro AE, Fioravanti M (1992) Idebenone in senile dementia of Alzheimer type: a multicentre study. Arch Gerontol Geriatr 15: 249–260
Smith MA, Sayre L, Perry G (1996) Is Alzheimer’s a disease of oxidative stress? Alzheimer’s Dis Rev 1: 63–67
Stevens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson J, Brown MJ (1996) Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347: 781–787
Sunderland T, Tariot PN, Cohen RM, Newhouse PA, Mellow AM, Mueller EA, Murphy DL (1987) Dose-dependent effects of deprenyl on CSF metabolites in patients with Alzheimer’s disease. Psychopharmacology 91: 293–296
Suno M, Nagaoka A (1984) Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode oc action of the inhibition. Biochem Biophys Commun 125: 1046–1052
Tariot P, Cohen R, Sunderland T, Newhouse P, Yount D, Mellow A, Weingartner H, Mueller E, Murphy D (1987a) L-deprenyl in Alzheimer’s disease. Arch Gen Psychiatry 44: 427–433
Tariot P, Sunderland T, Weingartner H, Murphy D, Welkowitz J, Thompson K, Cohen R (1987b) Cognitive effects of 1-deprenyl in Alzheimer’s disease. Psychopharmacology 91: 489-95
Thome J, Münch G, Müller R, Schinzel R, Kornhuber J, Blum-Degen D, Sitzmann L, Rösler M, Heidland A, Riederer P (1996) Advanced glycation endproducts—associated parameters in the blood of patients with Alzheimer’s disease. Life Sci 59: 679–685
Thome J, Gsell W, Rösler M, Kornhuber J, Frölich L, Hashimoto E, Zielke B, Wiesbeck GA, Riederer P (1997) Oxidative-stress associated parameters (lactoferrin, superoxide dismutase) in serum of patients with Alzheimer’s disease. Life Sci 60: 13–19
Weitbrecht WU, Jansen W (1986) Primär degenerative Demenz: Therapie mit Ginkgo-biloba-Extract. Fortschr Med 104: 199–202
Weyer G, Erzigkeit H, Hadler D, Kubicki S (1996) Efficacy and safety of idebenone in the longterm treatment of Alzheimer’s disease: a double-blind, placebo controlled multicentre study. Hum Psychopharmacol 11: 53–65
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Wien
About this chapter
Cite this chapter
Rösler, M., Retz, W. (1999). Therapie von oxidativem Streß. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6400-6_71
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6400-6_71
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7315-2
Online ISBN: 978-3-7091-6400-6
eBook Packages: Springer Book Archive