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Peripheral Axotomy Challenges the Central Motor Neuron and its Cellular Microenvironment

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From Neuron to Action

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Abstract

For several good reasons the nervous system is classified into a peripheral (PNS) and a central (CNS) part with distinct and in many respects different properties. One such difference is the capacity for regeneration and functional restitution after a lesion, which is present in peripheral nerves but is widely lacking in neurons of the brain and the spinal cord. An exception to this rule is the motoneuron. Motoneuron cell bodies are located in the CNS, and they have the morphology, the dendritic and synaptic organization typical of large brain stem neurons, i.e. they are essentially central neurons except for the course of their axons. Thus, they leave the CNS to innervate extrinsic target tissue, e.g. muscle or ganglia. In response to an injury to its peripheral axon the motoneuron has the full capacity to regenerate by growing a new axon which under favourable conditions is able to reach and innervate the target tissue leading to a restoration of function.

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Author information

Authors and Affiliations

  1. Max Planck Institute for Psychiatry, Department of Neuromorphology, Am Klopferspitz 18 A, 8033, Planegg-Martinsried, Germany

    G. W. Kreutzberg

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  1. G. W. Kreutzberg
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Editor information

Editors and Affiliations

  1. Neurological University Clinic Vienna, Lazarettgasse 14, 1090, Vienna, Austria

    Lüder Deecke

  2. Ca’ a la Gra’, 6646, Contra (Locarno) TI, Switzerland

    John C. Eccles

  3. Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, 21205, Baltimore, MD, USA

    Vernon B. Mountcastle

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© 1990 Springer-Verlag Berlin Heidelberg

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Kreutzberg, G.W. (1990). Peripheral Axotomy Challenges the Central Motor Neuron and its Cellular Microenvironment. In: Deecke, L., Eccles, J.C., Mountcastle, V.B. (eds) From Neuron to Action. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02601-4_46

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  • DOI: https://doi.org/10.1007/978-3-662-02601-4_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02603-8

  • Online ISBN: 978-3-662-02601-4

  • eBook Packages: Springer Book Archive

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