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Drugs Acting on Dermal Connective Tissue

  • Chapter
Pharmacology of the Skin II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

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Abstract

The dermis is a complex tissue composed of differentiated fibroblasts embedded in an extracellular matrix containing various macromolecules: collagens, proteoglycans, elastin and glycoproteins. Interactions between these various constituents and with the cells determine the architectural organisation and the function of the supporting network. The different steps and their potential controls operating in the synthesis, degradation and organisation of these molecules are described in Chap. 9. Each of these steps can potentially be modified or modulated by exogenous agents. The discovery of pharmacological agents active in some of them and the knowledge of their mode of action has helped to elucidate physiological mechanisms. Much of the information about the pharmacology of the dermis is related to fibroblasts and mainly one of their biosynthetic products, collagen. This protein will be considered as a model compound to monitor the activity of drugs on the tissue. Some information will also be briefly presented about elastin, proteoglycans and glycoproteins in the dermis and in tissues other than skin.

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Authors
  1. B. Nusgens
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  2. C. M. Lapière
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Editor information

Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Nusgens, B., Lapière, C.M. (1989). Drugs Acting on Dermal Connective Tissue. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_27

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74056-5

  • Online ISBN: 978-3-642-74054-1

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