Abstract
Isosorbide dinitrate (ISDN) is widely used for the treatment of angina pectoris and has been shown to prolong exercise tolerance during acute and sustained therapy [1–8]. However, ISDN is poorly bioavailable after oral intake, and a marked inter-individual variation in plasma ISDN concentrations has been reported after oral doses during both acute and chronic therapy [4]. After oral ingestion, ISDN is rapidly metabolized into 2- and 5-mononitrates, both of which are biologically active. Now commercially available in Europe, isosorbide-5-mononitrate (IS-5-MN) has a half-life of 4–6 h and is almost 100% bioavailable after oral ingestion [9]. The latter makes this compound pharmacokinetically more desirable than its parent compound ISDN. Furthermore, a slow-release formulation of IS-5-MN providing high plasma levels for up to 24 h is now available which should theoretically offer advantages by exerting antianginal effects over a prolonged period of time.
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Thadani, U., Hamilton, S., Teague, S., Brady, D., White, B. (1985). Slow-Release Isosorbide-5-Mononitrate for the Treatment of Angina Pectoris: Duration of Effects. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_22
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DOI: https://doi.org/10.1007/978-3-642-70234-1_22
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