Abstract
Research and development in the field of oxygen therapeutics has made substantial progress in the past two decades. However, significant challenges have been encountered, as highlighted at an NIH/FDA/HHS workshop in 2008.
A full list of the Working Group members are provided at the end of the article.
Source: National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services (http://www.nhlbi.nih.gov/meetings/workshops/therapeutics.htm)
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References
Baron D, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker A, Malhotra R, Bloch KD, Zapol WM (2012) Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology
Boretti FS, Buehler PW, D’Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ (2009) Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest 119:2271–2280
Buehler PW, D’Agnillo F, Hoffman V, Alayash AI (2007) Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther 323:49–60
Butt OI, Buehler PW, D’Agnillo F (2011) Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol 178:1316–1328
Doherty DH, Doyle MP, Curry SR, Vali RJ, Fattor TJ, Olson JS, Lemon DD (1998) Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol 16:672–676
Gould SA, Moss GS (1996) Clinical development of human polymerized hemoglobin as a blood substitute. World J Surg 20:1200–1207
Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT (2003) Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer’s solution, hypertonic saline dextran, and HBOC-201. J Trauma 54:242–252
Koike K, Kondo Y, Sekiya M, Sato Y, Tobino K, Iwakami SI, Goto S, Takahashi K, Maruyama N, Seyama K, Ishigami A (2010) Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice. Am J Physiol Lung Cell Mol Physiol 298:L784–L792
Lieberthal W, Fuhro R, Freedman JE, Toolan G, Loscalzo J, Valeri CR (1999) O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J Pharmacol Exp Ther 288:1278–1287
Nelson D, Hai T, Srnak A, Ebeling A, Kunas G, Catarello J, Burhop K (1992) Synthesis and properties of polymerized, diaspirin cross-linked hemoglobins. Biomater Artif Cells Immobilization Biotechnol 20:253–258
Schmidt U, Han RO, DiSalvo TG, Guerrero JL, Gold HK, Zapol WM, Bloch KD, Semigran MJ (2001) Cessation of platelet-mediated cyclic canine coronary occlusion after thrombolysis by combining nitric oxide inhalation with phosphodiesterase-5 inhibition. J Am Coll Cardiol 37:1981–1988
Silverman TA, Weiskopf RB (2009a) Hemoglobin based oxygen carriers: current status and future directions. Transfusion 49:2495–2515
Silverman TA, Weiskopf RB (2009b) Hemoglobin based oxygen carriers: current status and future directions. Anesthesiology 111:946–963
Viele M, Weiskopf R, Fisher D (1997) Renal effects and pharmacokinetics of recombinant human hemoglobin. Anesthesiology 86:848–858
Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ (2007) Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. Blood 110:2166–2172
Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM (2010) Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology 112:586–594
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Mitchell, P., Weiskopf, R., Zapol, W.M. (2013). NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics. In: Kim, H., Greenburg, A. (eds) Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40717-8_8
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DOI: https://doi.org/10.1007/978-3-642-40717-8_8
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