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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

  • Hae Won Kim
  • A. Gerson Greenburg

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Introduction and Scientific Principles

    1. Front Matter
      Pages 1-1
    2. Andrea Mozzarelli, Stefano Bruno, Luca Ronda
      Pages 55-73
    3. Amy G. Tsai, Judith Martini, Beatriz Y. Salazar Vázquez, Pedro Cabrales, Seetharama A. Acharya, Marcos Intaglietta
      Pages 75-93
  3. Hemorrhagic Shock and Current Treatments

    1. Front Matter
      Pages 95-95
    2. Fredric M. Pieracci, Walter L. Biffl
      Pages 97-116
    3. Mercy Kuriyan, Jeffrey L. Carson
      Pages 117-126
    4. Robert M. Van Haren, Chad M. Thorson, Col Lorne H. Blackbourne, Kenneth G. Proctor
      Pages 127-138
  4. Current Issues of HBOCs and Regulatory Framework

    1. Front Matter
      Pages 139-139
    2. Phyllis Mitchell, Richard Weiskopf, Warren M. Zapol
      Pages 141-147
  5. Approaches to HBOCs

    1. Front Matter
      Pages 157-157
    2. Ronald Kluger, Francine E. Lui
      Pages 159-183
    3. Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai, Fantao Meng
      Pages 185-234
    4. Xianren Wu, Nancy T. Ho, Tong-Jian Shen, Vincent Vagni, David K. Shellington, Keri Janesko-Feldman et al.
      Pages 249-272
    5. Li Ma, Frances M. Thompson, Dong Wang, Carleton J. C. Hsia
      Pages 299-313
    6. Teruyuki Komatsu
      Pages 339-348
    7. Marie Grey, Khuanpiroon Ratanasopa, Leif Bülow
      Pages 349-358
  6. Potential Applications of HBOCs

    1. Front Matter
      Pages 367-367
    2. Akira T. Kawaguchi, Chieko Murayama, Fumiaki Yoshiba, Hiroyuki Furuya, Mariko Yamano, Munetaka Haida
      Pages 369-383
    3. Tao Li, Chengmin Yang, Jin Liu, Jiaxin Liu, Wang Hong
      Pages 399-410
    4. P. S. Reynolds, R. W. Barbee, K. R. Ward
      Pages 411-433
  7. Preclinical Evaluations of HBOCs

    1. Front Matter
      Pages 455-455
    2. Charles Auker, Paula Moon-Massat, Anke Scultetus, Richard McCarron, Daniel Freilich
      Pages 475-499
  8. HBOC Clinical Trials

  9. HBOC-Mediated Adverse Effects

  10. A Call for Collaborative Research and Development

About this book

Introduction

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

Keywords

Artificial Oxygen Carrier Artificial Red Cells Blood Substitute Hemoglobin-Based Oxygen Carrier Oxygen Therapeutic Red Blood Cell Substitute Transfusion Alternative

Editors and affiliations

  • Hae Won Kim
    • 1
  • A. Gerson Greenburg
    • 2
  1. 1.Brown UniversityBarringtonUSA
  2. 2.Brown UniversityBarringtonUSA

Bibliographic information