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Systemic Disease Affecting the Stomach

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Esophageal and Gastric Disorders in Infancy and Childhood

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Abstract

This chapter reviews systemic conditions that cause macroscopic and microscopic mucosal changes such as gastritis, which may be clinically and histologically distinct from primary inflammation. A gastric mucosal biopsy unifies the findings of the endoscopist and the histopathologist and may identify a systemic inflammatory disorder or vasculitis, infiltrative disease, or neoplasia. A number of systemic diseases interfere with smooth muscle or neuronal function and are associated with motility disorders of the stomach and delayed gastric emptying (gastroparesis). Gastric neoplasias are rare and almost always unexpected findings; however, it is important to be aware of conditions that predispose to gastric cancer such as primary immunodeficiencies, organ or bone marrow transplantation, and hereditary polyposis syndromes.

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Authors and Affiliations

  1. Department of Gastroenterology & Nutrition, Birmingham Children’s Hospital NHS Trust, Birmingham, B4 6NH, UK

    Sue Protheroe

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  1. Sue Protheroe
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Correspondence to Sue Protheroe .

Editor information

Editors and Affiliations

  1. Medical University of Graz, Graz, Austria

    Holger Till

  2. Sheffield Children’s Hospital, Paediatric Gastroenterology Centre, Sheffield, United Kingdom

    Mike Thomson

  3. Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    John E. Foker

  4. Department Surgery, University of Missouri, Kansas City Children’s Mercy Hospital, Kansas City, Missouri, USA

    George W. Holcomb III

  5. University of Arizona, Tucson, Arizona, USA

    Khalid M. Khan

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Protheroe, S. (2017). Systemic Disease Affecting the Stomach. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_126

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  • DOI: https://doi.org/10.1007/978-3-642-11202-7_126

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