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A Multiscale Model of Cell Migration in Three-Dimensional Extracellular Matrix

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Cell Movement

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Abstract

Cell migration in a three-dimensional (3D) extracellular matrix (ECM) is one of the key biological processes. Yet many fundamental questions remain unanswered. In this chapter, we introduce a modeling framework for a 3D, element-based, multiscale cell migration model. This model takes into account the mechanosensing signaling pathway, cell morphological dynamics, and cell-ECM interactions. To integrate the mechanochemical dynamics, we developed an implicit integration method to calculate forces for the elements and a moving boundary reaction-diffusion solver. The model is partially tested for cell migration on a curved substrate. Further development is needed to couple the cell model with a mechanical ECM model. This model can be used to test hypotheses of cell-ECM interactions and cell migration in tissue environment.

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Authors and Affiliations

  1. Department of Mathematics, Georgia State University, 25 Park Place NE STE 1400, 30303, Atlanta, GA, USA

    Xiuxiu He & Yi Jiang

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  1. Xiuxiu He
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  2. Yi Jiang
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Correspondence to Yi Jiang .

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Editors and Affiliations

  1. Mathematics, University of St. Thomas, Saint Paul, MN, USA

    Magdalena Stolarska

  2. Mathematics, Purdue University Northwest, Hammond, IN, USA

    Nicoleta Tarfulea

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He, X., Jiang, Y. (2018). A Multiscale Model of Cell Migration in Three-Dimensional Extracellular Matrix. In: Stolarska, M., Tarfulea, N. (eds) Cell Movement. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-96842-1_3

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