Skip to main content

Multi-pathway Risk Assessment of Trihalomethanes Exposure in Drinking Water Supplies

  • Chapter
  • First Online:
Trends in Asian Water Environmental Science and Technology

Abstract

Disinfection is the last step in the water treatment processes for the protection of public health. In India, chlorine is used as the primary disinfectant because of its low cost and convenience for application in water purification. However, chlorination results in formation of trihalomethanes (THMs) in drinking water which can pose severe health threat due to their potential carcinogenicity. In recent decades, various epidemiological studies have been conducted to determine the relationship between THMs and different health outcomes e.g., cancers and reproductive outcomes (Hrudey 2009). Llopis-González et al. (2011) suggested that exposure to THMs increase the risk of bladder, colon, rectum, leukemia, stomach and rectal cancers. The results of animal studies have demonstrated that liver, kidney and intestinal tumorigenesis are associated with chronic ingestion of THMs (Yang et al. 2000). Since THMs are the most prevalent and well documented disinfection by product (DBP) compounds in drinking water, they are generally considered as indicators of DBP exposure in epidemiological investigations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amjad, H., Imran, H., Rehman, M.S.U., Awan, M.A., Ghaffar, S. and Khan, Z. (2013). Cancer and non-cancer risk assessment of trihalomethanes in urban drinking water supplies in Pakistan. Ecotox Environ Safe, 91: 25–31.

    Article  CAS  Google Scholar 

  • Charrois, J.W.A., Graham, D., Hrudey, S.E. and Froese, K.L. (2004). Disinfection By-Products in small Alberta community drinking-water supplies. J Toxicol Environ Health Part A, 67: 1797–1803.

    Article  CAS  Google Scholar 

  • Chowdhury, S., Rodriguez, M. and Sadiq, R. (2011). Disinfection byproducts in Canadian provinces: Associated cancer risks and associated medical expenses. J Hazard Mater, 187: 574–584.

    Article  CAS  Google Scholar 

  • Gratt, L.B. (1996). Air Toxic Risk Assessment and Management. Van Nostrand Reinhold, New York, NY.

    Google Scholar 

  • Hasan, A., Thacker, N.P. and Bassin, J. (2010). Trihalomethane formation potential in treated water supplies in urban metro city. Environ Monit Assess, 168(1–40): 489–497.

    Article  CAS  Google Scholar 

  • Hoffman, C.S., Mendola, P., Savitz, D.A., Herring, A.H., Loomis, D., Hartmann, K.E., Singer, P.C., Weinberg, H.S. and Olshan, A.F. (2008). Drinking water disinfection by-product exposure and fetal growth. Epidemiology, 19: 729–737.

    Article  Google Scholar 

  • Hrudey, S.E. (2009). Chlorination disinfection by-products, public health risk tradeoffs and me. Water Res., 43: 2057–2092.

    Article  CAS  Google Scholar 

  • ICMR (2009). Nutrient requirements and recommended dietary allowances for Indians. A Report of the Expert Group of the Indian Council of Medical Research.

    Google Scholar 

  • IPCS (2009). Disinfectants and disinfectant by-products. International programme on chemical safety. Environmental Health Criteria Geneva: World Health Organization.

    Google Scholar 

  • IS 10500 (2012). Indian Standard Drinking Water Specification, Second Revision. ICS 13.060.20.

    Google Scholar 

  • Jo, W.K., Weisel, C.P. and Lioy, P.J. (1990). Routes of chloroform exposures and body burden from showering with chlorinated tap water. Risk Anal., 10: 575–580.

    Article  CAS  Google Scholar 

  • Karim, Z., Mumtaz, M. and Kamal, T. (2011). Health risk assessment of trihalomethanes of tap water in Karachi, Pakistan. J Chem Society, 33: 215–219.

    CAS  Google Scholar 

  • Lee, S.C., Guo, H., Lam, S.M.J. and Lau, S.L.A. (2004). Multi-pathway risk assessment on disinfection by-products of drinking water in Hong Kong. Environ Res., 94: 47–56.

    Article  CAS  Google Scholar 

  • Legay, C., Rodriguez, M.J., Sadiq, R., Serodes, J.B., Levallois, P. and Proulx, F. (2011). Spatial variations of human health risk associated with exposure to chlorination by-products occurring in drinking water. J Environ Manage., 92: 892–901.

    Article  CAS  Google Scholar 

  • Llopis-González, A., Sagrado-Vives, S., Gimeno-Clemente, N., Yusà-Pelecha, V., Martí-Requena, P., Monforte-Monleón, L. and Morales-Suárez-Varela, M. (2011). Ecological Study on Digestive and Bladder Cancer in Relation to the Level of Trihalomethanes in Drinking Water. Int J Environ Res., 5(3): 613–620.

    Google Scholar 

  • Pardakhti, A.R., Bidhendi, G.R.N., Torabian, A., Karbassi, A. and Yunesian, M. (2011). Comparative cancer risk assessment of THMs in drinking water from well water sources and surface water sources. Environ Monit Assess., 179: 499–507.

    Article  CAS  Google Scholar 

  • Summerhayes, R.J., Morgan, G.C., Lincoln, D., Edwards, H.P., Earnest, A., Rahman, M.B., Byleveld, P., Cowie, C.T. and Beard, J.R. (2011). Spatio-temporal variation in trihalomethanes in New South Wales. Water Res., 45: 5719–5726.

    Article  Google Scholar 

  • Tokmak, B., Capar, G., Dilek, F.B. and Yetis, U. (2004). Trihalomethanes and associated potential cancer risks in the water supply in Ankara, Turkey. Environ Res., 96: 345–352.

    Article  CAS  Google Scholar 

  • USEPA (1991). Risk assessment guidance for superfund, Vol. I, Part B. Environmental Protection Agency, Washington, DC, US. EPA/540/R-92/003.

    Google Scholar 

  • USEPA (1995). Method 551. Determination of chlorinated disinfection by-products and chlorinated solvents in drinking water by liquid-liquid extraction and gas chromatography with electron-capture detection. Environmental monitoring Systems Laboratory, Office of Research and Development, US Environmental Protection Agency, Cincinnati, Ohio.

    Google Scholar 

  • USEPA (1999). Guidelines for Carcinogen Risk Assessment. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington DC. NCEA-F-0644 (Revised draft).

    Google Scholar 

  • USEPA (2000). Supplementary guidance for conducting health risk assessment of chemical mixtures. United States Environmental Protection Agency. EPA/630/R-00/002.

    Google Scholar 

  • USEPA (2002). Integrated Risk Information System (Electronic data base). U.S. Environmental Protection Agency, Washington DC. Retrived October, 2013, from http://www.epa.gov/iris.

  • USEPA (2005a). Integrated Risk Information System (IRIS). Online. National Center for Environmental Assessment, Washington, DC.

    Google Scholar 

  • USEPA (2005b). Guidelines for carcinogen risk assessment, risk assessment forum. U.S. Environmental Protection Agency, Washington, DC. EPA/630/P-03/001 F.

    Google Scholar 

  • USEPA (2011). US Environmental Protection Agency, Edition of the Drinking Water Standards and Health Advisories. Office of Water U.S. Environmental Protection Agency, Washington, DC.

    Google Scholar 

  • Uyak, V. (2006). Multipathway risk assessment of trihalomethanes exposure in Istanbul drinking water supplies. Environ Int., 32: 12–21.

    Article  CAS  Google Scholar 

  • Viana, R.B., Cavalcante, R.M., Braga, F.M.G., Viana, A.B., Araujo, J.C., Nascimento, R.F. and Pimentel, A.S. (2009). Risk assessment of trihalomethanes from tap water in Fortaleza, Brazil. Environ Monit Assess., 151: 317–325.

    Article  CAS  Google Scholar 

  • Wang, G-S., Deng, Y-C. and Lin, T-F. (2007). Cancer risk assessment from trihalomethanes in drinking water. Sci Total Environ., 387: 86–95.

    Article  Google Scholar 

  • Weisel, C.P. and Jo, W.-K., 1996. Ingestion, inhalation and dermal exposure to chloroform and trichloroethene from tap water. Environ. Health Perspect. 104, 48–51.

    Google Scholar 

  • Yang, C.Y., Cheng, B.H., Tsai, S.S., Wu, T.N., Lin, M.C. and Lin, K.C. (2000). Association between chlorination of drinking water and adverse pregnancy outcome in Taiwan. Environ Health Persp., 108(8): 765–768.

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The author acknowledges the Ministry of Drinking Water and Sanitation (GOI), New Delhi for providing financial grant for carrying out the research work.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Minashree Kumari .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Capital Publishing Company, New Delhi, India

About this chapter

Cite this chapter

Kumari, M., Gupta, S.K. (2017). Multi-pathway Risk Assessment of Trihalomethanes Exposure in Drinking Water Supplies. In: Kurisu, F., Ramanathan, A., Kazmi, A., Kumar, M. (eds) Trends in Asian Water Environmental Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-39259-2_19

Download citation

Publish with us

Policies and ethics