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Causes and Consequences of Sensory Hair Cell Damage and Recovery in Fishes

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Fish Hearing and Bioacoustics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 877))

Abstract

Sensory hair cells are the mechanotransductive receptors that detect gravity, sound, and vibration in all vertebrates. Damage to these sensitive receptors often results in deficits in vestibular function and hearing. There are currently two main reasons for studying the process of hair cell loss in fishes. First, fishes, like other non-mammalian vertebrates, have the ability to regenerate hair cells that have been damaged or lost via exposure to ototoxic chemicals or acoustic overstimulation. Thus, they are used as a biomedical model to understand the process of hair cell death and regeneration and find therapeutics that treat or prevent human hearing loss. Secondly, scientists and governmental natural resource managers are concerned about the potential effects of intense anthropogenic sounds on aquatic organisms, including fishes. Dr. Arthur N. Popper and his students, postdocs and research associates have performed pioneering experiments in both of these lines of fish hearing research. This review will discuss the current knowledge regarding the causes and consequences of both lateral line and inner ear hair cell damage in teleost fishes.

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Acknowledgements

The authors express their gratitude to both Arthur N. Popper and Richard R. Fay for their many years of exceptional research on fish hearing and bioacoustics and their leadership and mentoring in this field. MES thanks Art Popper for his first postdoctoral job and for the wise advice, friendship, and consummate mentoring at the University of Maryland, where the author began his career in fish hearing research and started examining the effects of sound on fishes. Art provided numerous career development opportunities to present research at conferences, to receive specific training, e.g., a course on Acoustic Communication in Denmark, to team-teach courses, to collaborate on broader lab projects, and to network with other researchers in the field of fish hearing. Of course, Dick Fay was one of those colleagues that Art introduced MES to and he is grateful for Dick’s advice on projects, particularly the work on the tonotopic organization of the goldfish saccule. MES thanks numerous undergraduate researchers, former graduate students Julie Schuck, Chia-Hui Lin, Yajie Wang, Gopinath Rajadinakaran, and Bethany Coffey, and former postdoctoral researchers Todd Penberthy and Huifang Sun, for their many hours of auditory evoked potential recordings and inner ear dissections to examine hair cell and hearing loss in fishes.

Research in the Smith lab was supported by the National Institute of General Medical Sciences of the NIH (P20 RR-16481, 8 P20 GM103436-12, 2 P20 GM103436-14), a Kentucky Science and Engineering Foundation Research & Development Excellence Grant (KSEF-148-502-14-325), and an NSF SOMAS Award (DUE-0426266). We thank Drs. Allison Coffin and Joseph Sisneros for helpful comments on an earlier draft of this manuscript.

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  1. Department of Biology, Western Kentucky University, Bowling Green, KY, 42101, USA

    Michael E. Smith & J. David Monroe

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    Joseph A. Sisneros

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Smith, M.E., Monroe, J.D. (2016). Causes and Consequences of Sensory Hair Cell Damage and Recovery in Fishes. In: Sisneros, J. (eds) Fish Hearing and Bioacoustics. Advances in Experimental Medicine and Biology, vol 877. Springer, Cham. https://doi.org/10.1007/978-3-319-21059-9_17

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