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Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss

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New Therapies to Prevent or Cure Auditory Disorders

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Abstract

A number of drugs currently in use clinically are known to produce hearing loss. These drugs are mainly therapeutic agents, which include aminoglycoside antibiotics and platinum-based anticancer drugs. Another class of agents that have recently been recognized as ototoxins are the cyclodextrins, which are used in the pharmaceutical industry to improve solubility, bioavailability, stability, and drug delivery. These drugs target cells in the cochlea, mostly hair cells, by increasing oxidative stress and induction of cochlear inflammatory processes and cell death, and generally produce permanent hearing loss. This review provides evidence of hearing loss associated with the administration of these drugs in experimental animals and humans, details the mechanisms underlying ototoxicity and provide potential strategies for reducing hearing loss. It is hoped that the information presented would prompt further studies into validating the efficacy of otoprotective agents described and provide the rationale for additional clinical studies in humans.

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Acknowledgements

The authors would like to acknowledge funding from NIH grants RO1-CA166907 and RO1-DC016835 (to V.R.) and RO1-DC002396 (to L.P.R.), which support studies from the authors’ laboratories described in this review.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA

    Chaitanya Mamillapalli

  2. Department of Endocrinology, Springfield, Clinic, Springfield, IL, USA

    Chaitanya Mamillapalli

  3. Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA

    Asmita Dhukhwa, Leonard P. Rybak & Vickram Ramkumar

  4. Department of Pharmaceutical Sciences, Larkin University College of Pharmacy, Miami, FL, USA

    Sandeep Sheth

  5. Division of Otolaryngology, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA

    Debashree Mukherjea & Leonard P. Rybak

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  1. Chaitanya Mamillapalli
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  4. Debashree Mukherjea
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Correspondence to Vickram Ramkumar .

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Editors and Affiliations

  1. CILcare, Advanced Solution for Drug Development in Hearing Disorder, Montpellier, France

    Sylvie Pucheu

  2. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Kelly E. Radziwon

  3. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Richard Salvi

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Mamillapalli, C., Dhukhwa, A., Sheth, S., Mukherjea, D., Rybak, L.P., Ramkumar, V. (2020). Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss. In: Pucheu, S., Radziwon, K., Salvi, R. (eds) New Therapies to Prevent or Cure Auditory Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-40413-0_3

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