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Overview and Understanding of Human Circadian Immunology

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Allergy and Sleep

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Abstract

Immune cells have their own “circadian clock” and are under circadian control due to endogenous and exogenous factors, resulting in time of day differences in cell counts and function. Functionally human circadian immunology plays a crucial role in appropriate timing of vaccination, immunotherapy, treatment of infections, and exacerbation of inflammatory disease. Despite the breakthroughs described in this chapter, more work is needed. Specific areas would improve the care of allergic disease, including better knowledge of human immune rhythms and disease-specific research. Dr. Fishbein and her team have developed innovative approaches to the measurement of human immune rhythms. A personalized, timed-based treatment approach is in the future for allergic disease.

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Authors and Affiliations

  1. Division of Allergy & Immunology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University, Chicago, IL, USA

    Nurcicek Padem

  2. Division of Allergy & Immunology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Anna Fishbein

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  1. Nurcicek Padem
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  1. Northwestern University, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Anna Fishbein

  2. Northwestern University, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Stephen H. Sheldon

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Padem, N., Fishbein, A. (2019). Overview and Understanding of Human Circadian Immunology. In: Fishbein, A., Sheldon, S. (eds) Allergy and Sleep. Springer, Cham. https://doi.org/10.1007/978-3-030-14738-9_4

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