Abstract
Immune responses are known to be regulated by complicated interactions of T-cell subsets that play different functional roles.(1–6) In our previous studies of the cellular mechanisms in the suppression of antibody response, at least three functionally distinct subsets of suppressor T cells, i.e., suppressor T cells producing antigen-specific factor (TsF), suppressor T cells with acceptor site for TsF (acceptor T cell), and effector-suppressor T cells, were found to be involved in the regulatory T-cell interactions.(1) The initial step of suppressor T cell interaction is a process of activation of acceptor T cells by an antigen-specific TsF. The effector-suppressor T cells are then generated under the influence of activated acceptor T cells. Therefore, antigen-specific TsF mediates the regulatory T-cell interaction in which no direct cell contact is necessary. Moreover, antigen-specific TsF seems not to be an effector-suppressor molecule but rather a molecule whose function is to activate other subsets of suppressor T cells. In this sense, the antigen-specific TsF appears to work as a device to recognize antigens and also to communicate with other T cells.
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References
Taniguchi, M., and Tokuhisa, T., 1980, Cellular consequences in the suppression of antibody response by the antigen-specific suppressor T cell factor, J. Exp. Med. 151:517–527.
Waltenbaugh, C., Theze, J., Kapp, J. A., and Benacerraf, B., 1977, Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT). III. Generation of suppressor T cells by a suppressive extract derived from GT-primed lymphoid cells, J. Exp. Med. 146:970–985.
Eardley, D. D., Kemp, J., Shen, F. W., Cantor, H., and Gershon, R. K., 1979, Immunoregulatory circuits among T cell sets: Effect of mode of immunization on determining which Lyl T cell will be activated, J. Immunol. 122:1663–1665.
Dorf, M. E., Okuda, K., and Minami, M., 1982, Dissection of a suppressor cell cascade, Curr. Top. Microbiol. Immunol. 100:61–67.
Germain, R. N., Theze, J., Waltenbaugh, C., Dorf, M. E., and Benacerraf, B., 1978, Antigen specific T cell mediated suppression. II. In vitro induction of I-J coded L-glutamic acid50-L-tyrosine50 (GT)-specific T cell suppressor factor (GT-TsF) of suppressor T cells (Ts2) bearing distinct I-J determinants, J. Immunol. 121:602–607.
Sy, M.-S., Dietz, M. H., Germain, R. N., Benacerraf, B., and Greene, M. I., 1980, Antigen- and receptor- driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induced second-order suppressor T cells which express anti-idiotypic receptors,J. Exp. Med. 151:1183–1195.
Taniguchi, M., Saito, T., and Tada, T., 1979, Antigen-specific suppressive factor produced by a transplantable I-J bearing T cell hybridoma, Nature 278:555–558.
Taniguchi, M., Takei, I., and Tada, T., 1980, Functional and molecular organization of an antigen-specific suppressor factor derived from a T cell hybridoma, Nature 283:227–228.
Saito, T., and Taniguchi, M., 1983, Chemical features of an antigen-specific suppressor T cell factor composed of two polypeptide chains, submitted J. Mol. Cell. Immunol. (in press).
Tokuhisa, T., Komatsu, Y., Uchida, Y., and Taniguchi, M., 1982, Monoclonal antibodies specific for the constant region of the T cell antigen-receptors, J. Exp. Med. 156:888–897.
Kanno, M., Kobayashi, S., Tokuhisa, T., Takei, I., Shinohara, N., and Taniguchi, M., 1981, Monoclonal antibodies that recognize the product controlled by a gene in the I-J subregion of the mouse H-2 complex, J. Exp. Med. 154:1290–1304.
Taniguchi, M., Saito, T., Takei, I., and Tokuhisa, T., 1981, Presence of interchain S-S bonds between two gene products that compose the secreted form of an antigen-specific suppressor factor, J. Exp. Med. 153:1672–1677.
Taniguchi, M., Tokuhisa, T., Kanno, M., Yaoita, Y., Shimizu, A., and Honjo, T., 1982, Reconstitution of an antigen-specific suppressor activity with the translation products of mRNA coding for the antigen- binding and the I-J bearing molecules, Nature 298:172–174.
Fresno, M., McVay-Boudreau, L. and Cantor, H., 1982, Antigen-specific T lymphocyte clones. III. Papain splits purified T suppressor molecules into two functional domains, J. Exp. Med. 155:981–993.
Taniguchi, M., Takei, I., Saito, T., and Tokuhisa, T., 1981, Activation of an acceptor T cell hybridoma by a VH I-J+ monoclonal suppressor factor, in: Immunoglobulin idiotypes (C. A. Janeway, Jr., E. E. Sercarz, and H. Wigzell, eds.), Academic Press, New York, pp. 397–406.
Steinmetz, M., Minard, K., Hovath, S., McNicholas, J., Frelinger, J., Wake, C., Long, E., Mach, B., and Hood, L., 1982, A molecular map of the immune response region from the major histocompatibility complex of the mouse, Nature 300:35–42.
Chirgwin, J. M., Prezybyla, A. E., MacDonald, R. J., and Rutter, W. J., 1979, Isolation of biochemically active ribonucleic acid from sucroses enriched in ribonuclease, Biochemistry 18:5294–5299.
O’Farrell, P. H., 1975, High resolution two dimensional electrophoresis of proteins, J. Biol. Chem. 250:4007–4021.
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© 1984 Plenum Press, New York
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Taniguchi, M., Takei, I., Sumida, T., Kanno, M., Tagawa, M., Ito, T. (1984). Suppressor T-Cell Hybridoma with a Receptor Recognizing KLH-Specific Suppressor Factor. In: Greene, M.I., Nisonoff, A. (eds) The Biology of Idiotypes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4739-2_27
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DOI: https://doi.org/10.1007/978-1-4684-4739-2_27
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