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Cholinergic Mechanisms in Aggressive Behavior

Role of Muscarinic and Nicotinic Systems

  • Chapter
Central Cholinergic Mechanisms and Adaptive Dysfunctions

Abstract

It has been suggested (Scott, 1958; Valzelli, 1967) that aggression is not a unitary concept. This premise is based on the fact that stimulus situations eliciting aggression are so diverse and hence there must be several types of behavior. It followed from this that there would be a variety of physiological substrates involved in the mediation of these different aggression types. Only recently, however, has any systematic attempt been made to list the types of aggression and indicate a basis for classification. Moyer (1968), suggested that if there were several forms of aggression, then progress in understanding the general phenomenon of this behavior could be made only when the various types were carefully and operationally defined. The definitional phase must then be followed by research in which experimental manipulations are applied to the subjects who are then tested in a variety of situations which define the various classes of aggression. A given manipulation may very well facilitate one kind of aggression, suppress another, and have no effect on a third (Moyer, 1968).

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References

  • Abood, L. G., Reynolds, D. T., Booth, H., and Bidlack, J. M., 1981, Sites and mechanisms for nicotine’s action in the brain, Neurosci. Biobehay. Rev. 5: 479–486.

    Article  CAS  Google Scholar 

  • Albert, D. J., 1980, Suppression of mouse killing by lateral hypothalamic infusion of atropine sulfate in the rat: a general behavioral suppression, Pharmacol. Biochem. Behay. 12: 681–688.

    Article  CAS  Google Scholar 

  • Alberts, J. R., and Freedman, M. I., 1972, Olfactory bulb removal but not anosmia increases emotionally and mouse-killing, Nature 238: 434–435.

    Article  Google Scholar 

  • Allikmets, L. H., 1974, Cholinergic mechanisms in aggressive behavior Med. Biol. 52: 19–30.

    CAS  Google Scholar 

  • Armitage, A. K., 1973, Some recent observations relating to the absorption of nicotine from tobacco smoke, in “Smoking Behavior,” W. L. Dunn, ed., pp. 83–91, Winston J. Wiley, Washington, D.C.

    Google Scholar 

  • Armitage, A. K., Dollery, C. T., George, C. F., Houseman, T. H., Lewis P. J., and Turner, D. M., 1974, Absorption and metabolism of nicotine by man during cigarette smoking, Br. J. Clin. Pharmacol. 1: 180P - 181 P.

    Google Scholar 

  • Artho, A. J., and Grob, K., 1964, Nicotinabsorption aus dem Cigarettenrauch, Z. Praventiv. Med. 9: 14–25.

    Article  CAS  Google Scholar 

  • Avis, H. H., and Peeke, H. V. S., 1973, Scopolamine and intraspecific aggression in cichlasoma nigrofasciatum: evidence for cholinergic mechanism in fish aggression. Paper presented at the meeting of the Western Psychological Association, Anaheim, California.

    Google Scholar 

  • Azrin, N. H., Hutchinson, R. R., and Hake, D. F., 1967, Attach avoidance and escape reactions to aversive shock, J. Exp. Anal. Behay. 10: 131–148.

    Google Scholar 

  • Azrin, N. H., Ulrich, R. E., Hutchinson, R. R., and Norman, D. G., 1964, Effect of shock duration on shock-induced fighting, J. Exp. Anal. Behay. 7: 9–11.

    Google Scholar 

  • Balfour, D. J. K., 1973, Effects of nicotine on the uptake and retention of 14C-noradrenaline and 14C-5-hydroxytryptamine by rat brain homogenates, Eur. J. Pharmacol. 23: 19–26.

    Google Scholar 

  • Bandler, R. J., 1971b, Chemical stimulation of the rat midbrain and aggressive behavior, Nature 229: 222–223.

    Article  CAS  Google Scholar 

  • Bandler, R. J., 1970, Cholinergic synapses in the lateral hypothalamus for the control of predatory aggression in the rat, Brain Res. 20: 409–424.

    Article  PubMed  Google Scholar 

  • Bandler, R. J., 1971a, Direct chemical stimulation of the thalamus: effects on aggressive behavior in the rat, Brain Res. 26: 81–93.

    Article  CAS  Google Scholar 

  • Bandler, R. J., 1969, Facilitation of aggressive behavior in the rat by direct cholinergic stimulation of the hypothalamus, Nature 224: 1035–1036.

    Article  PubMed  CAS  Google Scholar 

  • Bandler, R. J., 1975, Predatory aggression: midbrain-pontine junction rather than hypothalamus as the critical structure? Aggress. Behay. 1: 261–266.

    Google Scholar 

  • Barclay, A. M., and Haber, R. N., 1965, The relation of aggressive to sexual motivation, J. Pers. 3: 462–475.

    Article  Google Scholar 

  • Baxter, B. L., 1967, Comparison of the behavioral effects of electrical or chemical stimulation applied at the same loci, Exp. Neurol. 19: 412–432.

    Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1979b, Comparative study of aggressive behavior after injection of cholinomimetics, anticholinesterases, nicotinic and muscarinic ganglionic stimulants into the cerebral ventricles of conscious cats: failure of nicotinic drugs to evoke aggression, Psychopharmacology 60: 147–153.

    Article  PubMed  CAS  Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1979d, Effects of 6-hydroxydopamine and reserpine on aggressive behavior induced by cholinomimetic and anticholinesterase injections into cerebral ventricles of conscious cats: dissociation of biting attack from snarling and hissing, Psychopharmacology 61: 149–153.

    Article  PubMed  CAS  Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1979a, Effects of paracholorophenylalanine and 5, 6-dihydroxytryptamine on aggressive behavior evoked by cholinomimetics and anticholinesterases injected into the cerebral ventricles of conscious cats, Neuropharmacology 18: 251–257.

    CAS  Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1979e, Evidence of central cholinergic mechanisms in the appearance of affective aggressive behavior: dissociation of aggression from autonomic and motor phenomena, Psychopharmacology 62: 163–167.

    Article  PubMed  CAS  Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1977, Muscarine-and carbacholinduced aggressions: fear and irritable kinds of aggression, Psychopharmacology 55: 233–236.

    Article  PubMed  CAS  Google Scholar 

  • Beleslin, D. B., and Samardzic, R., 1979c, The pharmacology of aggressive behavioral phenonema elicited by muscarine injected into the cerebral ventricles of conscious cats, Psychopharmacology 60: 155–158.

    Article  PubMed  CAS  Google Scholar 

  • Bell, R., and Brown, K., 1980, Shock induced defensive fighting in the rat: evidence for cholinergic mediation in the lateral hypothalamus, Pharmacol. Biochem. Behay. 12: 487–491.

    Google Scholar 

  • Bernstein, H., and Moyer, K. E., 1970, Aggressive behavior in the rat: effects of isolation and olfactory bulb lesions, Brain Res. 20: 75–84.

    Article  PubMed  CAS  Google Scholar 

  • Bernston, G. G., Beattie, M. S., Walker, J. M., 1976, Effects of nicotinic and muscarinic compounds on biting attack in the cat, Pharmacol. Biochem. Behay. 5: 235–239.

    Google Scholar 

  • Blanchard, R. J., Blanchard, D. C., and Takahashi, L. K., 1977

    Google Scholar 

  • Reflexive fighting in the albino rat: aggressive or defensive behavior, Aggress. Behay. 3:145–155.

    Google Scholar 

  • Blanchard, R. J., Fukunaga, K. K., Blanchard, D. C., and Kelley, M. J., 1975, Conspecific aggression in the rat, J. Comp. Physiol. Psychol. 89: 1204–1209.

    Google Scholar 

  • Bonnet, K. A., Freidhoff, A. J., Anderson, L. T., Green, W. H., 1980, Anticholinergic remediation of human aggression resulting from an organic brain syndrome, Prog. Clin. Biol. Res. 39: 462.

    Google Scholar 

  • Brudzynski, S. M., 1981a, Carbachol-induced agonistic behavior in cats: aggressive or defensive response? Acta Neurobiol. Exp. 41: 15–32.

    CAS  Google Scholar 

  • Brudzynski, S. M., 1981b, Growling component of vocalization as a quantitative index of carbachol-induced emotional-defensive response in cats, Acta. Neurobiol. Exp. 41: 33–52.

    Google Scholar 

  • Brudzynski, S. M., Kielczykowska, E., Romaniuk, A., 1982, The effects of external stimuli on the emotional-aversive response evoked by intrahypothalamic carbachol injections, Behay. Brain Res. 4: 33–43.

    Google Scholar 

  • Cain, D. P., 1974, Olfactory bulbectomy: neural structures involved in irritability and aggression in the male rat, J. Comp. Physiol. Psychol. 86: 213–220.

    Google Scholar 

  • Cain, D. P., and Paxinos, G., 1974, Olfactory bulbectomy and mucosal damage: effects on copulation, irritability and interspecific aggression in male rats, J. Comp. Physiol. Psychol. 86: 202–212.

    Google Scholar 

  • Charpentier, J., 1969, Analysis and measurement of aggressive behavior in mice, in “Aggressive Behavior,” S. Garattini and E. B. Sigg, eds., pp. 86–100, Wiley, New York.

    Google Scholar 

  • Chaurand, J. P., and Karli, P., 1970, Effects of lesions of the central gray matter of the mesencephalon on the interspecific aggressive behavior and the feeding habits of the rat, C. R. Soc. Biol. 164: 1345–1380.

    Google Scholar 

  • Chaurand, J. P., Schmitt, P., Karli, P., 1972, Substance grise central du mesencephale et le comportement d’agression interspecifique du rat, Physiol. Behay. 9: 475–481.

    Google Scholar 

  • Chaurdan, J. P., Vergnes, M., Karli, P., 1973, Effets du lesions du tegmentum ventral du mesencephale sur le comportement d’agression rat-souris, Physiol. Behay. 10: 507–517.

    Google Scholar 

  • Cherek, D. R., 1981, Effects of smoking different doses of nicotine on human aggression behavior, Psychopharmacology 75: 339–345.

    Article  PubMed  CAS  Google Scholar 

  • Colpaert, F. C., 1975, The ventromedial hypothalamus and the control of avoidance behavior and aggression: fear hypothesis versus response-suppression theory of limbic system function, Behay. Biol. 15: 27–44.

    Google Scholar 

  • Consolo, S., and Valzellí, L., 1970, Brain choline acetylase and monoamine oxidase activity in normal and aggressive mice, Eur. J. Pharmac. 13: 129–130.

    Google Scholar 

  • Creer, T. L., and Powell, D. A., 1971, The effect of repeated shock presentations and different stimulus intensities on shock-induced aggression, Psychon. Sci. 24: 133–134.

    Google Scholar 

  • DaVanzo, J. P., 1969, Observations related to drug-induced alterations in aggressive behavior, in “Aggressive Behavior,” S. Garattini and E. B. Sig, eds., pp. 263–272, Wiley, New York.

    Google Scholar 

  • Decsi, L., and Nagy, J., 1974, Chemical stimulation of the amygdala with special regard to influence on the hypothalamus, Neuropharmacology 13: 1153–1162.

    Article  PubMed  CAS  Google Scholar 

  • De Souza, H., and Palermo-Neto, J., 1982, A quantitative study of cholinergic-dopaminergic interactions in the CNS, Pharmacology 24: 222–229.

    Article  PubMed  Google Scholar 

  • Didiergeorges, F., and Karli, P., 1967, Hormones steroides et maturation d’un comportement d’agression interspécifique du rat, C. R. Soc. Biol. 161: 179–181.

    Google Scholar 

  • Didiergeoroges, F., and Karli, P., 1966, Stimulation “sociales” et inhibition de l’agressivité interspécifique chez le rat privé de ses afférences olfactives, C. R. Soc. Biol. 160: 2445–2447.

    Google Scholar 

  • Didiergeorges, F., Vergnes, M., Karli, P., 1966, Privation des afférences olfactives et aggressivite interspecifique du rat, C. R. Soc. Biol. 160: 866–868.

    Google Scholar 

  • Doll, R., and Hill, A. B., 1964, Mortality in relation to smoking: ten years’ observations of British doctors, Br. Med. J. 1:1339–1410 and 1460–1467.

    Google Scholar 

  • Dreyer, P. I., and Church, R., 1968, Shock-induced fighting as a function of the intensity and duration of the aversive stimulus, Psychon. Sci. 10: 271–272.

    Google Scholar 

  • Driscoll, P., and Beattig, K., 1981, Selective inhibition by nicotine of shock-induced fighting in the rat, Pharmacol. Biochem. Behay. 14: 175–179.

    Google Scholar 

  • Eclancher, F., and Karli, P., 1971, Comportement d’agression inter-spécifique et comportement alimentaire du rat: effets de lésions des noyaux ventromédians de l’hypothalamus, Brain Res. 21: 57–70.

    Google Scholar 

  • Eclancher, F., and Karli, P., 1969, Comportement d’agression inter-spécifique rat-souris: effets de lesions du noyau dorso-médian du thalamus et des structures epithalamiques, J. Physiol. ( Paris ) 61: 283.

    Google Scholar 

  • Eclancher, F., and Karli, P., 1968, Lésion du noyan dorso-médian du thalamus et comportement d’agression interspécifique rat-souris, C. R. Soc. Biol. 162: 2273–2276.

    Google Scholar 

  • Edwards, A. E., and Adams, D. B., 1974, Role of midbrain central gray in pain induced defensive boxing of rats, Physiol. Behay. 13: 113–121.

    Google Scholar 

  • Egbe, P. C., 1982, The involvement of the catecholaminergic system in physostigmine-induced hyperactivity in rats, Arzneim-Forsch 32: 27–29.

    CAS  Google Scholar 

  • Eleftheriou, B. E., ed., 1972, “The Neurobiology of the Amygdala, Vol. 2 Adv. Behay. Biol.,” Plenum Press, New York.

    Google Scholar 

  • Emley, G. S., Hutchinson, R. R., Hunter, N. A., 1971, Selective actions of morphine, chlorpromazine, chlordiazepoxide, nicotine and d’amphetamine on shock-produced aggressive and motor responses in the squirrel monkey, Fed. Proc. 30: 390.

    Google Scholar 

  • Essman, W. B., 1971, Changes in cholinergic activity and avoidance behavior by nicotine in differentially housed mice, Int. J. Neurosci. 2: 199–205.

    Google Scholar 

  • Garattini, S., and Sigg, E. B., 1969, “Aggressive Behavior,” Wiley, New York.

    Google Scholar 

  • Gianutsos, G., and Lal, H., 1976, Blockade of apomorphine-induced aggression by morphine or neuroleptics: differential alteration by antimuscarinics and naloxone, Pharmacol. Biochem. Behay. 4: 639–642.

    Google Scholar 

  • Gianutsos, G., and Lal, H., 1977, Modification of apomorphine induced aggression by changing central cholinergic activity in rats, Neuropharmacology 16: 7–10.

    Article  PubMed  CAS  Google Scholar 

  • Grossman, S. P., 1972b, Aggression, avoidance and reaction to novel environments in female rats with VMH lesions, J. Comp. Physiol. Psychol. 78: 274–283.

    Google Scholar 

  • Grossman, S. P., 1970, Intracranial administration of drugs and emotional behavior, in “The Physiology of Emotion,” P. Black, ed., pp. 73–79, Academic Press, New York.

    Google Scholar 

  • Grossman, S. P., 1972a, The ventromedial hypothalmus and aggressive behaviors, Physiol. Behay. 9: 721–725.

    Google Scholar 

  • Hernandez-Peon, R., Chavez-Ibarra, G., Morgane, P. J., Timo-Zaria, C., 1963, Limbic cholinergic pathways involved in sleep and emotional behavior, Exp. Neurol. 8: 93–111.

    Google Scholar 

  • Horovitz, Z. P., Piala, J. J., High, J. P., Burke, J. C., and Leaf, R. C., 1966, Effects of drugs on the mouse-killing (muricide) test and its relationship to amygdaloid function, Int. J. Neuropharmacol. 5: 405–411.

    Google Scholar 

  • Hull, C. D., Buchwald, N. A., Ling, G. M., 1967, Effects of direct cholingeric stimulation of forebrain structures,Brain Res. 6: 22–35.

    Article  PubMed  CAS  Google Scholar 

  • Hutchinson, R. R., and Emley, G. S., 1973, Effects of nicotine on avoidance conditioned suppression and aggression response measures in animals, and man, in “Smoking Behavior,” W. L. Dunn, ed., pp. 171–196, Winston (J. Wiley), Washington, D.C.

    Google Scholar 

  • Hutchinson, R. R., and Emley, G. S., 1981, Nicotine ingestion reduces elevated blood pressures in rats and squirrel monkeys, Life Sci. 28: 801–809.

    Article  PubMed  CAS  Google Scholar 

  • Igic, R., Stern, P., Basagic, E., 1970, Changes in emotional behavior after application of cholinesterase inhibitor in the septal and amygdala regions, Neuropharmacology 9: 73–75.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, B. L., and Cohen, A., 1976, Differential behavioral effects of lesions of the median or dorsal raphe nuclei in rats: open field and pain elicited aggression, J. Comp. Physiol. Psychol. 90: 102–108.

    Google Scholar 

  • Karczmar, A. G., and Scudder, C. L., 1969, Aggression and neurochemical changes in different strains and genera of mice, in “Aggressive Behavior,” S. Garattini, and S. B. Sigg, eds., pp. 209–227, Wiley, New York.

    Google Scholar 

  • Karli, P., 1960, Septum, hypothalamus posterieur et agressivité inter-spécifique rat-souris, J. Physiol. ( Paris )

    Google Scholar 

  • Karli, P., 1956, The Norway rat’s killing response to the white mouse: an experimental analysis, Behavior 10: 81–103.

    Article  Google Scholar 

  • Karli, P., and Vergnes, M., 1964, Dissociation expérimentale du comportement d’agression interspécifique rat-souris et du comportement alimentaire, C. R. Soc. Biol. 158: 650–653.

    Google Scholar 

  • Karli, P., and Vergnes, M., 1965, Role des différentes composantes du complexe nucléaire amygdalien dans la facilitation de l’agressivité interspécifique du rat, C. R. Soc. Biol. 159: 754–756.

    Google Scholar 

  • Karli, P., Vergnes, M., Didiergeorges, F., 1969, Rat-mouse aggressive behavior and its manipulation by brain ablation and brain stimulation, in “Aggressive Behavior,” S. Garattini and S. B. Sigg, eds., pp. 47–55, Wiley, New York.

    Google Scholar 

  • Karli, P., Vergnes, M., Eclancher, F., Schmitt, P., Chaurand, J. P., 1972, Role of amygdala in the control of mouse-killing behavior in the rat, in “The Neurobiology of the Amygdala, Vol. 2,” B. E. Eleftheriou, ed., pp. 553–480, Plenum Press, New York.

    Google Scholar 

  • Katz, R. J., 1981, Possible muscarinic-cholinergic mediation of patterned aggressive reflexes in the cat, Prog. Neuropsychopharmacol. 5: 49–56.

    Google Scholar 

  • Kesner, R. P., and Keiser, G., 1973, Effects of midbrain reticular lesions upon aggression in the rat, J. Comp. Physiol. Psychol. 84: 194–206.

    Google Scholar 

  • Kimbrell, G. M. A., 1969, Relationship of upright posture in foot-shock situation to dominance-submission in male C57BL/6 mice, Psychon. Sci. 16: 167–168.

    Google Scholar 

  • King, M. B., and Hoebel, B. G., 1968, Killing elicited by brain stimulation in rats, Commun. Behay. Biol. 2: 173–177.

    Google Scholar 

  • Knutson, J. R., and Hynan, M. T., 1972, Influence of upright posture on shock-elicited aggression in rats, J. Comp. Physiol. Psychol. 81: 297–306.

    Google Scholar 

  • Kostowski, W., 1968, A note on the effects of some cholinergic and anticholinergic drugs on the aggressive behavior and spontaneous electrical activity of central nervous system in the ant, formica rufa, J. Pharm. Pharmacol. 20: 381–384.

    Google Scholar 

  • Krsiak, M. and Tomasikova, Z., 1980, Effects of scopolamine on agonistic behavior in mice, Act. Nerv. Super. 22: 201–203.

    Google Scholar 

  • Krsiak, M., Sulcova, A., Tomasikova, Z., 1981, Drug effects on attack, defense and escape in mice, Pharmacol. Biochem. Behay. 14 (Suppl. 1): 49–52.

    Article  Google Scholar 

  • Ladinsky, H., Consolo, S., Tierelli, A. S., Forloni, G. L., Segal, M., 1981, Regulation of cholinergic activity in the rat hippocampus: in vivo effects of oxotremrine and fenfluramine, Adv. Behay. Biol. 25: 781–793.

    Google Scholar 

  • Leaf, R. C., Lerner, L., and Horovitz, Z. P., 1969, The role of the amygdala in the pharmacological and endocrinological manipulation of aggression, in “Aggressive Behavior,” S. Garattini and E. B. Sigg, eds., pp. 120–131, Wiley, New York.

    Google Scholar 

  • Legrand, R. and Fielder, R., 1973, Role of dominance-submission relationships in shock induced fighting in mice, J. Comp. Physiol. Psychol. 82: 501–506.

    Google Scholar 

  • Leroux, A. G., and Myers, R. D., 1975, Action of serotonin microinjected into hypothalamus sites at which electrical stimulation produced aversive responses in the rat, Physiol. Behay. 14: 501–505.

    Google Scholar 

  • Malick, J. B., 1970, A behavioral comparison of three lesion-induced models of aggression in the rat, Physiol. Behay. 5: 679–681.

    Google Scholar 

  • Malick, J. B., and Barnett, A., 1976, The role of serotonergic pathways in isolation induced aggression in mice, Pharmacol. Biochem. Behay. 5: 55–61.

    Google Scholar 

  • Mandel, P., Mack, G., and Kempf, E., 1979, Molecular basis of some models of aggressive behavior in “Psychopharmacology of Aggression,” M. Sandler, ed., pp. 95–110, Raven Press, New York.

    Google Scholar 

  • Marlatt, A., 1979, A cognitive-behavioral model of the relapse process, in “Behavioral Analysis and Treatment of Substance Abuse,” J. Krasnegor, Ed., pp. 191–199, National Institute for Drug Abuse, Washington, D.C.

    Google Scholar 

  • Mausner, J. S., 1980, Cigarette smoking among patients with respiratory disease, Ann. Rev. Respir. Dis. 102: 704–706.

    Google Scholar 

  • McCarthy, D., 1966, Mouse-killing in rats treated with pilocarpine, Fed. Proc. 15: 293–298.

    Google Scholar 

  • McKennell, A. C., 1970, Smoking motivation factors, Br. J. Soc. Clin. Psychol. 9: 8–22.

    Google Scholar 

  • Meierl, G., and Schmidt, W. J., 1982, No evidence for cholinergic mechanisms in the control of spontaneous predatory behavior of the ferret, Pharmacol. Biochem. Behay. 16: 677–681.

    Google Scholar 

  • Mollenauer, S., White, M., Plotnik, R., Tiffany, P. B., 1979, Physostigmine: effects on fear or defense responses in the rat, Pharmacol. Biochem. Behay. 11: 189–195.

    Google Scholar 

  • Moyer, K. E., 1968, Kinds of aggression and their physiological basis, Commun. Behay. Biol. 2: 65–87.

    Google Scholar 

  • Moyer, K. E., 1976, “The Psychobiology of Aggression,” Harper and Row, New York.

    Google Scholar 

  • Myers, R. D., 1964, Emotional and autonomic responses following hypothalamic chemical stimulation, Can. J. Psychol. 18: 6–14.

    Google Scholar 

  • Nordberg, A., and Larsson, C., 1981, Search for nicotine-like receptor binding sites in brain, Adv. Behay. Biol. 25: 639–646.

    Google Scholar 

  • O’Kelly, L. W., and Steckle, L. C., 1939, A note on long-enduring emotional responses in the rat, J. Psychol. 8:125–131. Oldendorf, W. H., 1977, Distribution of drugs in the brain, in “Psychopharmacology in the Practice of Medicine,” M. E. Jarvik, ed., pp. 167–175, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Panksepp, J., 1971, Effects of hypothalamic lesions on mouse-killing and shock-induced fighting in rats, Physiol. Behay. 6: 311–316.

    Google Scholar 

  • Panksepp, J., and Trowill, J., 1969, Electrically-induced affective attack from hypothalamus of the albino rat, Psychon. Sci. 16: 118–119.

    Google Scholar 

  • Plotnik, R., Mollenauer, S., Gore, W., Popov, A., 1975, Comparing the effects of scopolamine on operant and aggressive responses in squirrel monkeys, Pharmacol. Biochem. Behay. 3: 739–748.

    Google Scholar 

  • Reynierse, J. H., 1971, Submissive postures during shock-elicited aggression, Anim. Behay. 19: 102–107.

    Google Scholar 

  • Rodgers, R. J., 1979a, Effects of nicotine, mecamylamine and hexamethonium on shock-induced fighting, pain reactivity and locomotor behavior in rats, Psychopharmacology 66: 93–98.

    Article  PubMed  CAS  Google Scholar 

  • Rodgers, R. J., 1979b, Neurochemical correlates of aggressive behavior: some relations to emotion and pain sensitivity, in “Chemical Influences on Behavior,” K. Brown and S. J. Cooper, eds., pp. 373–419, Academic Press, New York.

    Google Scholar 

  • Rodgers, R. J., 1977, The medical amygdala: serotonergic inhibition of shock-induced aggression and pain sensitivity in rats, Aggress. Behay. 3: 277–288.

    Google Scholar 

  • Rodgers, R. J., 1975, The role of central cholinergic mechanisms in shock-induced aggression in rats, Unpublished PhD Thesis, Queen’s University of Belfast.

    Google Scholar 

  • Rodgers, R. J., and Brown, K., 1976, Amygdaloid function in the central cholinergic mediation of shock-induced aggression in the rat, Aggress. Behay. 2: 131–152.

    Google Scholar 

  • Rodgers, R. J., and Brown, K., 1973b, Increased shock-induced attack in rats by physostigmine, IRCS Med. Sci. 75–79.

    Google Scholar 

  • Rodgers, R. J., and Brown, K., 1973a, The inhibition of shock-induced attack in rats by scopolamine, IRCS Med. Sci. 73–75.

    Google Scholar 

  • Rodgers, R. J., Semple, J. M., Cooper, S. J., Brown, K., 1976, Shock-induced aggression and pain sensitivity in the rat: catecholamine involvement in the corticomedial amygdala, Aggress. Behay. 2: 193–204.

    Google Scholar 

  • Rolinski, 1977, The role of serotonergic and cholinergic systems in the aggression stereotype complex produced by amphetamine in mice, Pol. J. Pharmacol. Pharm. 29: 591–602.

    PubMed  CAS  Google Scholar 

  • Rolinski, Z., and Herbut, M., 1979, Determination of the role of serotonergic and cholinergic systems in apomorphine induced aggressiveness in rats, Pol. J. Pharmacol. Pharm. 31: 97–106.

    Google Scholar 

  • Rolinski, Z., and Herbut, M., 1981, The importance of central nicotinic receptors in foot-shock-induced aggression in mice, Pol. J. Pharmacol. Pharm. 33: 569–576.

    Google Scholar 

  • Romaniuk, A., Brudzynski,S., Gronska, J., 1974, The effects of intra-hypothalamic injections of cholinergic and adrenergic agents on defensive behavior in cats, Acta Physiol. Pol. 25: 297–305.

    Google Scholar 

  • Romaniuk, A., Golebiewski, H., 1977, Midbrain interaction with the hypothalamus in expression of aggressive behavior in cats, Acta. Neurobiol. Exp. 37: 83–97.

    Google Scholar 

  • Russell, M. A. H., Peto, J., and Patel, U. A., 1974, The classification of smoking by factorial structure of motives, Roy. Stat. Soc. J. (A) 137: 313–333.

    Google Scholar 

  • Schachter, S., 1978, Pharmacological and psychological determinants of smoking, in “Smoking Behavior,” R. E. Thornton, ed., pp. 208–228, Churchill-Livingstone, Edinburgh.

    Google Scholar 

  • Schechter, M.D., and Rand, M. J., 1974, Effect of acute deprivation of smoking on aggression and hostility, Psychopharmacology 35: 19–28.

    Article  Google Scholar 

  • Schmiterlow, C. G., Hansson, E., Andersson, G., Appelgren, L. E., and Hoffman, P. C., 1967, Distribution of nicotine in the central nervous system, Ann. N. Y. Acad. Sci. 142: 2–14.

    Google Scholar 

  • Scott, J. P., 1958, “Aggression,” University of Chicago Press, Chicago.

    Google Scholar 

  • Scott, J. P., 1966, Agonistic behavior in mice and rats: a review, Am. Zool. 6: 683–701.

    Google Scholar 

  • Shiffman, S. M., 1979, Analysis of relapse episodes following smoking cessation. Paper presented at the 4th World Congress on Smoking and Health.

    Google Scholar 

  • Shiffman, S. M., and Jarvik, M. E., 1976, Smoking withdrawal symptoms in two weeks of abstinence, Psychopharmacology 50: 35–39.

    Article  PubMed  CAS  Google Scholar 

  • Siegel, A., and Edinger, H., 1981, Neural control of aggression and rage behavior, in “Handbook of the Hypothalamus, Vol. 3., Part B,” P. J. Morgane and J. Panksepp, eds., pp. 203–240, Dekker, New York.

    Google Scholar 

  • Silverman, A. P., 1979, Aggression in a social context: what can drugs do? In “Psychopharmacology of Aggression,” Merton Sandler, ed., Raven Press, New York.

    Google Scholar 

  • Silverman, A. P., 1971, Behavior of rats given a smoking dose of nicotine, Anim. Behay. 19: 67–72.

    Google Scholar 

  • Smith, D. E., King, M. B., Hoebel, B. G., 1970, Lateral hypothalamic control of killing: evidence for a cholinoceptive mechanism, Science 167: 900–901.

    Article  PubMed  CAS  Google Scholar 

  • Spector, S. A., and Hull, E. M., 1972, Anosmia and mouse-killing by rats: a non-olfactory role for the olfactory bulbs, J. Comp. Physiol. Psychol. 80: 354–356.

    Google Scholar 

  • Stern, P., Igic, R., and Muftis, R., 1975, Cholinergic mechanisms and aggressivity, in “Cholinergic Mechanisms,” P. G. Waser, ed., pp. 477–482, Raven Press, New York.

    Google Scholar 

  • Stokman, C. L. J., and Glusman, M., 1981, Directional interaction of midbrain in hypothalamus in the control of carbachol-induced aggression, Aggress. Behay. 7: 131–144.

    Google Scholar 

  • Thomas, C. B., 1973, The relationship of smoking and habits of nervous tension, in “Smoking Behavior,” W. L. Dunn, ed., pp. 157–170, Winston (Wiley), New York.

    Google Scholar 

  • Thor, D. H., Ghiselli, W. B., Lambelet, D. C., 1974, Sensory control of shock-elicited fighting in rats, Physiol. Behay. 13: 683–686.

    Google Scholar 

  • Thorne, B. M., Aaron, M., Latham, E. E., 1973, Effects of olfactory bulb ablation upon emotionally and muricidal behavior in four rat strains, J. Comp. Physiol. Psychol. 84: 339–344.

    Google Scholar 

  • Thorne, B. M., Aaron, M., Latham, E. E., 1974, Olfactory system damage in rats and emotional, muricidal and rat pup-killing behavior, Physiol. Psychol. 2: 157–163.

    Google Scholar 

  • Ulrich, R. E., and Azrin, N. H., 1962, Reflexive fighting in response to aversive stimulation, J. Exp. Anal. Behay. 5: 511–520.

    Google Scholar 

  • Ulrich, R., Wolfe, M., Dulaney, S., 1969, Punishment of shock-induced aggression, J. Exp. Anal. Behay. 12: 1009–1015.

    Google Scholar 

  • Uyeno, E. T., and White, M., 1967, Social isolation and dominance behavior, J. Comp. Physiol. Psychol. 63: 157–159.

    Google Scholar 

  • Valzelli, L., 1967, Drugs and Aggressiveness, Adv. Pharmacol. 5: 79–108.

    Google Scholar 

  • Vergnes, M., 1976, Contrôle amygdalien de comportements d’aggression chez le rat, Physiol. Behay. 17: 439–444.

    Google Scholar 

  • Vergnes, M., and Chaurand, J. P., 1973, Effets comportement aux de lesions de la partie posterieure de la substance grise periacqueductale, C. R. Soc. Biol. 167: 351–356.

    Google Scholar 

  • Vergnes, M., and Karli, P., 1963a, Declenchment du comportement d’agression interspecifique rat-souris par ablation bilaterale des bulbs olfactifs. Acetion de l;hydroxyzine sur cette aggressivite provoquee, C. R. Soc. Biol. 157: 1061–1063.

    Google Scholar 

  • Vergnes, M., and Karli, P., 1969, Effects of stimulation of lateral hypothalamus, amygdala and hippocampus on interspecific rat-mouse aggressive behavior, Physiol. Behay. 4: 889–894.

    Google Scholar 

  • Vergnes, M., and Karli, P., 1963b, Effets de lesions experimentales du neocortex frontal et du noyau caude sur l’agressivite interspecifique rat-souris, C. R. Soc. Biol. 157: 176–177.

    Google Scholar 

  • Vergnes, M., and Karli, P., 1970, Elicitation of mouse-killing behavior by electrical stimulation of the medial hypothalamus in the rat, Physiol Behay. 5: 1427–1430.

    Article  CAS  Google Scholar 

  • Vergnes, M., and Karli, P., 1972, Stimulation electrique du thalamus dorsomedian et comportement d’agression interspecifique du rat, Physiol. Behay. 9: 889–892.

    Google Scholar 

  • Vergnes, M., Mack, G., and Kempf, E., 1973, Lesions due raphe et reaction d’agression interspecifique rat-souris. Effets comportement aux et biochemiques, Brain Res. 57: 67–74.

    Google Scholar 

  • Vogel, J. R., and Leaf, R. C., 1972, Initiation of mouse-killing in non-killer rats by repeated pilocarpine treatment, Physiol. Behay. 8: 421–424.

    Google Scholar 

  • Waldbillig, R. J., 1980, Suppressive effects of intraperitoneal and intraventricular injections of nicotine on muricide and shock-induced attack on conspecifics Pharmacol. Biochem. Behay. 12: 619–623.

    Google Scholar 

  • Warburton, D. M., and Wesnes, K., 1978, Individual differences in smoking and attentional performance, in “Smoking Behavior,” R. E. Thornton, ed., pp. 19–43, Churchill-Livingstone, Edinburgh.

    Google Scholar 

  • Waser, P. G., ed., 1975, “Cholinergic mechanisms,” Raven Press, New York.

    Google Scholar 

  • Westfall, T. C., 1974, Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices, Neuropharmacology 13: 693–700.

    Article  PubMed  CAS  Google Scholar 

  • Wnek, D. J., and Leaf, R. C., 1973, Effects of cholinergic drugs on prey-killing by rodents, Physiol. Behay. 10: 1107–1113.

    Google Scholar 

  • Woodworth, C. H., 1971, Attack elicited in rats by electrical stimulation of lateral hypothalamus, Physiol. Behay. 6: 345–353.

    Google Scholar 

  • Yoburn, B. C., Glusman, M., Potegal, M., Skaredoff, L., 1981, Facilitation of muricide in rats by cholinergic stimulation of the lateral hypothalamus, Pharmacol. Biochem. Behay. 15: 747–753.

    Google Scholar 

  • Yoshimura, H., and Ogawa, N., Pharmaco-ethological analysis of agonistic behavior between resident and intrude mice: effect of anticholinergic drugs, Jap. J. Pharmacol. 32: 1111–1116.

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, The Queen’s University of Belfast, Belfast, N. Ireland, UK

    Robert Bell & Kenneth Brown

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  1. Robert Bell
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  2. Kenneth Brown
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  1. Southern Illinois University School of Medicine, Springfield, Illinois, USA

    Man Mohan Singh

  2. University of Reading, Reading, UK

    David M. Warburton

  3. Texas College of Osteopathic Medicine, Fort Worth, Texas, USA

    Harbans Lal

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© 1985 Plenum Press, New York

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Bell, R., Brown, K. (1985). Cholinergic Mechanisms in Aggressive Behavior. In: Singh, M.M., Warburton, D.M., Lal, H. (eds) Central Cholinergic Mechanisms and Adaptive Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1218-5_6

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  • DOI: https://doi.org/10.1007/978-1-4684-1218-5_6

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