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Neonatal Graves’ Disease

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Graves’ Disease

Part of the book series: Endocrine Updates ((ENDO,volume 6))

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Abstract

The syndrome that is now commonly called neonatal Graves’ disease, i.e., hyperthyroidism of limited duration and occasionally associated with goiter and ophthalmopathy, was first reported in 1910 (1), followed by a case presentation in 1912 (2). Until 1974 an additional 75 cases were described (3) and since then the number has approximately doubled. As can be seen, the condition is not common. Considering that Graves’ disease occurs in about 0.2% of pregnant women (4) and overt thyrotoxicosis in approximately 2% of their offspring (4,5), the overall prevalence is of the order of 1 per 25,000 neonates (4) or even, as estimated by Fisher (6), 1 per 200,000. Still, the timely diagnosis of the syndrome is very important, since it can have dire consequences if left untreated (3,7).

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Authors
  1. Margita Zakarija
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  2. J. Maxwell McKenzie
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Editors and Affiliations

  1. Autoimmune Disease Unit, Cedars-Sinai Research Institute and U.C.L.A. School of Medicine, Los Angeles, California, USA

    Basil Rapoport M.B., Ch.B.  & Sandra M. McLachlan Ph.D  & 

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Zakarija, M., McKenzie, J.M. (2000). Neonatal Graves’ Disease. In: Rapoport, B., McLachlan, S.M. (eds) Graves’ Disease. Endocrine Updates, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4407-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-4407-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6983-7

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