Graves’ Disease

Pathogenesis and Treatment

  • Basil Rapoport
  • Sandra M. McLachlan

Part of the Endocrine Updates book series (ENDO, volume 6)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Robert Volpé, Clark Sawin
    Pages 1-8
  3. David Phillips
    Pages 9-18
  4. Basil Rapoport, Sandra M. McLachlan
    Pages 43-66
  5. Sandra M. McLachlan, Basil Rapoport
    Pages 67-78
  6. R. A. Ajjan, P. F. Watson, A. P. Weetman
    Pages 79-93
  7. Francesca Paolieri, Giampaola Pesce, Claudia Salmaso, Paola Montagna, Marcello Bagnasco
    Pages 95-105
  8. Peiqing Wu, James R. Baker Jr
    Pages 107-126
  9. Marian Ludgate, Sabine Costagliola, Gilbert Vassart
    Pages 127-138
  10. Michael M. Kaplan, Donald A. Meier
    Pages 139-152
  11. Milton D. Gross, John E. Freitas, James C. Sisson, B. Shapiro
    Pages 153-167
  12. Osamah Alsanea, Orlo H. Clark
    Pages 169-183
  13. Scott A. Rivkees
    Pages 185-203
  14. John H. Lazarus
    Pages 205-214
  15. Margita Zakarija, J. Maxwell McKenzie
    Pages 215-226
  16. Wolfgang Dillman
    Pages 227-234
  17. Peter H. K. Eng, Lewis E. Braverman
    Pages 235-247
  18. Rebecca S. Bahn
    Pages 249-256
  19. Leonard Wartofsky, Matthew D. Ringel, Kenneth D. Burman
    Pages 257-278
  20. Luigi Bartalena, Claudio Marcocci, Aldo Pinchera
    Pages 279-288
  21. Terry J. Smith
    Pages 289-300
  22. Back Matter
    Pages 301-307

About this book


From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete.
The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease.


Antigen apoptosis cytokine genetics immunotherapy pathogenesis

Editors and affiliations

  • Basil Rapoport
    • 1
  • Sandra M. McLachlan
    • 1
  1. 1.Autoimmune Disease UnitCedars-Sinai Research Institute and U.C.L.A. School of MedicineLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6983-7
  • Online ISBN 978-1-4615-4407-4
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site