Summary
B 21 is associated with resistance to Marek’s disease (MD). Forty populations of chickens from all over the world were examined for the presence of the B 21 allele. B 21 was found in twelve of these populations and it’s presence was confirmed by GVH testing in all ten populations which were tested. The populations in which B 21 was detected represent the extreme production types of the species and include the progenitor of the species, the Red Jungle Fowl. Our studies suggest that B 21 may have strong survival value for the species. An allogeneic transplantable lymphoma of MD, the JMV tumor cell line, grows more slowly in MD resistant chicks than in MD susceptible (B 2/ B 2) chicks. This is the first direct evidence that genetic resistance to MD may involve an active (immunological?) restriction of tumor cell growth. JMV cells were further characterized as a transplant of B1 carrying lymphoblastoid cells, an allele which may be associated with susceptibility to MD.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brewer, R.N., Moore, C.W. and Johnson, L.W., Poult. Sci. 48: 1790 (abstract) (1969).
Briles, W.E. in First World Congress on Genetics Applied to Livestock Production (Gráficas Orbe, Madrid), Vol. 1:299 (1974).
Briles, W.E. and Oleson, W.L., Poult. Sci. 50: 1558 (abstract) (1971).
Briles, W.E., Stone, H.A. and Cole, R.K., Sci. 195: 193 (1977).
Doherty, P.D. and Zinkernagel, R.M., J. Immunol. 114: 30 (1975).
Gavora, G.S., Spencer, J.L., Hare, W.C.D. and Morse, P.M., Poult. Sci., in press (1977).
Hanson, M.P., Van Zandt, J.N. and Law, G.R.J., Poult. Sci. 46: 1268 (abstract) (1967).
Hong, C.C. and Sevoian, M., Avian Dis. 18: 305 (1974).
Kim, S.N., Yoon, J.W., Olmsted, J. and Kenyon, A.M., Fed. Proc. 31: 260 (abstract) (1972).
Longenecker, B.M. Sheridan, S., Law, G.R.J, and Ruth, R.F., Transplantation 65:44–557 (1970).
Longenecker, B.M., Pazderka, F., Law, G.R.J, and Ruth, R.F., Transplantation 14: 424–431 (1972).
Longenecker, B.M., Pazderka, F., Gavora, J.S., Spencer, J.L. and Ruth, R.F., Immunogenetics 401–407 (1976).
Pazderka, F., Longenecker, B.M., Law, G.R.J., Stone, H.A. and Ruth, R.F., Immunogenetics 2: 93–100 (1975).
Pazderka, F., Longenecker, B.M., Law, G.R.J, and Ruth, R.F., Immunogenetics 2: 101–130 (1975).
Sevoian, M., Larose, R.N. and Chamberlain, D.M., Proc. 101st Ann. Mtg. Am. Vet. Med. Assoc. pp 342 (1964).
Spencer, J.L. and Calnek, B.W., Avian Dis. 11: 274 (1967).
Spencer, J.L., Gavora, J.S., Grunder, A.A., Robertson, A. and Speckman, G.A., Avian Dis. 18: 33 (1974).
Spencer, J.L., Gavora, J.A., Hare, A.A. and Grunder, A.A., Avian Dis. 20: 268 (1976).
Stephens, E.A., Witter, R.L., Lee, L.F., Sharma, J.M., Nazerian, K. and Longenecker, B.M., J. Natl. Can. Inst. 57: 865 (1976).
Weiss, R.A. and Biggs, P.M., J. Natl. Cancer Inst. 49: 1713 (1972).
Witter, R.L., Stephens, A., Sharma, J.M. and Nazerian, K., Jour. Immunol. 115: 177 (1975).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Longenecker, B.M. et al. (1977). Role of the Major Histocompatibility Complex in Resistance to Marek’s Disease: Restriction of the Growth of JMV-MD Tumor Cells in Genetically Resistant Birds. In: Benedict, A.A. (eds) Avian Immunology. Advances in Experimental Medicine and Biology, vol 88. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4169-7_27
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4169-7_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4171-0
Online ISBN: 978-1-4613-4169-7
eBook Packages: Springer Book Archive