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Diuretic Effect and Electrolyte Changes Caused by Oral Peg 200 in Rat

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Diuretics: Basic, Pharmacological, and Clinical Aspects

Part of the book series: Developments in Nephrology ((DINE,volume 18))

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Abstract

Polyethylene glycol (PEG 200) is a useful vehicle for the administration of drugs (1). In an earlier investigation when PEG 200 was administered to rats by gavage, we observed changes in sodium and water metabolism (2). The aim of the present work was to obtain further data in connection with this phenomenon.

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References

  1. MARTINDALE: Extra Pharmacopoeia 27, 630–632. Pharmaceutical Press, London 1977.

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  2. SONKODI, S., TICHY, B., ⋆BROWN, W.B., ⋆ROBERTSON, J.I.S. Clinical Science (1986) in press.

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  3. SMYTH, H.F., CARPENTER, C.P., and Well, C.S. The chronic oral toxicology of the polyethylene glycols.

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  4. WARREN, S.E., BLANTZ, R.C. Mannitol. Arch. Intern. Med. 141, 493–497, 1981.

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  5. CHURCHILL, P.C., CHURCHILL, M.C., and McDONALD, F.C. Effects of saline and mannitol on renin and distal tubule Na in rats. Circ. Res. 45, 786–791, (1979)

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© 1987 Martinus Nijhoff Publishing, Boston

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Sonkodi, S., Tichy, B., Brown, W., Robertson, J.I.S. (1987). Diuretic Effect and Electrolyte Changes Caused by Oral Peg 200 in Rat. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_125

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  • DOI: https://doi.org/10.1007/978-1-4613-2067-8_125

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9227-2

  • Online ISBN: 978-1-4613-2067-8

  • eBook Packages: Springer Book Archive

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