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Arf and Phospholipids

  • Chapter
ARF Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 1))

Abstract

Arfs have been implicated in remodeling of both biological membranes and the actin cytoskeleton. In each case, Arf function appears to be integrally related to lipid metabolism. As regulators of membrane traffic, Arfs bind to membrane surfaces and affect membrane structure. Effects of Arf on the actin cytoskeleton may be mediated through acid phospholipids. Examination of the interactions of Arfs and lipids has revealed complex relationships. Arfs directly bind lipids. Arfs also bind and activate two enzymes that metabolize lipids, phospholipase D and phosphatidylinositol 4-phosphate 5-kinase. The products of these enzymes, phosphatidic acid and phosphatidylinositol 4,5-bisphosphate, affect both positive and negative regulators of Arfs. Although precise mechanisms have yet to be defined, regulation of the concentrations of these signaling lipids appears to mediate at least some effects of Arfs.

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Authors and Affiliations

  1. Laboratory of Cellular Oncology, CCR, NCI, Bethesda, USA

    Paul A. Randazzo, Zhongzhen Nie & Dianne S. Hirsch

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  1. Paul A. Randazzo
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  2. Zhongzhen Nie
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  3. Dianne S. Hirsch
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© 2004 Springer Science + Business Media, Inc.

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Randazzo, P.A., Nie, Z., Hirsch, D.S. (2004). Arf and Phospholipids. In: ARF Family GTPases. Proteins and Cell Regulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2593-9_3

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  • DOI: https://doi.org/10.1007/1-4020-2593-9_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1719-3

  • Online ISBN: 978-1-4020-2593-8

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