ARF Family GTPases

1. Front Matter

   Pages i-xxviii

   PDF

2. The Arf Family Tree

   • John M. Logsdon Jr., Richard A. Kahn

   Pages 1-21

3. The GDP/GTP Cycle of Arf Proteins

   • Sebastiano Pasqualato, Louis Renault, Jacqueline Cherfils

   Pages 23-48

4. Arf and Phospholipids

   • Paul A. Randazzo, Zhongzhen Nie, Dianne S. Hirsch

   Pages 49-69

5. The Sec7 Family of Arf Guanine Nucleotide Exchange Factors

   • Catherine L. Jackson

   Pages 71-99

6. Large Arf GEFs of the Golgi Complex

   • Paul Melançon, Xinhua Zhao, Troy K. R. Lasell

   Pages 101-119

7. BIG1 and BIG2: Brefeldin A-Inhibited Exchange Factors for Arfs

   • G. Pacheco-Rodriguez, J. Moss, M. Vaughan

   Pages 121-135

8. Arf GTPase-Activating Protein 1

   • Dan Cassel

   Pages 137-157

9. GIT Proteins: Arf Gaps and Signaling Scaffolds

   • Robert Schmalzigaug, Richard Premont

   Pages 159-183

10. Paxillin-Associated Arf GAPs

    • Hisataka Sabe

    Pages 185-207

11. Activation of Cholera Toxin and E. Coli Heat-Labile Enterotoxin (LT) by Arf

    • G. Pacheco-Rodriguez, Naoko Morinaga, Masatoshi Noda, J. Moss, M. Vaughan

    Pages 209-222

12. Phospholipase D, Arfaptins and Arfophilin

    • John H. Exton

    Pages 223-240

13. Coat Proteins

    • Annette Boman, Tommy Nilsson

    Pages 241-257

14. Heterotetrameric Coat Protein-Arf Interactions

    • M. L. Styers, V. Faundez

    Pages 259-281

15. Arf6

    • James E. Casanova

    Pages 283-303

16. A Role for Arf6 in G Protein-coupled Receptor Desensitization

    • Mary Hunzicker-Dunn

    Pages 305-324

17. Arf-Like Proteins

    • Annette Schürmann, Hans-Georg Joost

    Pages 325-350

For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

• Activation
• Lipid
• Nucleotide
• cell biology
• metabolism
• proteins

From the reviews:

"A journey into a deeper understanding of the diversity of cellular controls exerted by the ARF family. The writing is so clear and well developed … it will allow newcomers in the area to dive into a dynamic area of molecular and cellular science. … the reader is treated to a wealth of discussion and critique on how ARFs modulate processes such as membrane fusion, vesicular transport, cell migration and receptor activity. This is an outstanding text for everyone with an interest in cell biology." (M. Thompson, Cell Biochemistry and Function, Vol. 23 (4), 2005)

• Emory University School of Medicine, Atlanta, USA

  Richard A. Kahn

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