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The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediators

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Functional Tissue Engineering

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Conclusion

Biomechanics at the level of individual cells, the microcirculation and the tissue is an effective tool to analyze important diseases such as stroke, myocardial infarction, or physiological shock. The biomechanics of inflammation needs to take center stage in the analysis of disease, organ rejection, or tissue engineering. There is a rich collection of problems that require analysis and finding solutions will be a rewarding exercise. The role of fluid shear stress in control of cells in the cardiovascular system is a major aspect of these problems.

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Authors
  1. Geert W. Schmid-Schönbein
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  2. Shunichi Fukuda
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Editors and Affiliations

  1. Orthopaedic Research Laboratories Department of Surgery 375 MSRB, Duke University Medical Center, Box 3093, Durham, NC, 22710, USA

    Farshid Guilak

  2. Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, Cincinnati, OH, 45221-0048, USA

    David L. Butler

  3. Orthopaedic Research Laboratories, University of Michigan, Room G-161, 400 North Ingalls, Ann Arbor, MI, 48105-0486, USA

    Steven A. Goldstein

  4. Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA

    David J. Mooney

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Schmid-Schönbein, G.W., Fukuda, S. (2003). The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediators. In: Guilak, F., Butler, D.L., Goldstein, S.A., Mooney, D.J. (eds) Functional Tissue Engineering. Springer, New York, NY. https://doi.org/10.1007/0-387-21547-6_25

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  • DOI: https://doi.org/10.1007/0-387-21547-6_25

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