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Genetics of Scars and Keloids

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Total Scar Management

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Abstract

Clinical, epidemiological, and experimental data suggest that genetics plays a role in the pathogenesis of keloids. In this chapter, we review the contribution of genetics to the pathobiology of keloids, including assessment of keloid-related syndromes, genetic linkage analyses, genome-wide association studies, individual fibrosis-related genes, and ongoing insights from genomic medicine. Collectively, the evidence improves understanding of the molecular basis of keloid formation, and indicates possible new strategies for prevention, diagnosis, and treatment.

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Authors and Affiliations

  1. Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Chao-Kai Hsu & Hsing-San Yang

  2. International Center for Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan

    Chao-Kai Hsu

  3. St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, Guy’s Hospital, London, UK

    John A. McGrath

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  1. Chao-Kai Hsu
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  2. Hsing-San Yang
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  3. John A. McGrath
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Correspondence to John A. McGrath .

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Editors and Affiliations

  1. Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan

    Rei Ogawa

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Hsu, CK., Yang, HS., McGrath, J.A. (2020). Genetics of Scars and Keloids. In: Ogawa, R. (eds) Total Scar Management. Springer, Singapore. https://doi.org/10.1007/978-981-32-9791-3_4

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  • DOI: https://doi.org/10.1007/978-981-32-9791-3_4

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