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Lecture

Gastrointestinal Hormones and Intestinal Motility

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Gastrointestinal Motility
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Abstract

In recent years, there has been a virtual explosion in discovery of various hormonal peptides isolated from the gastrointestinal tract and the pancreas. The truly remarkable development in digestive endocrinology could be attributed 1. to the successful isolation of what are generally regarded as the major gastrointestinal hormones (gastrin, CCK and secretin) — and since then, many peptides whose hormonal status has not yet been clarified and 2. to the application of highly sensitive methods of quantitative measurement of circulating hormones by radioimmunoassay and their tissue distribution by innunocytochenistry.

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References

  1. Dockray, G.B. (1979). Comparative biochemistry and physiology of gut hormones. Annu. Rev. Physiol. 41, 83–95

    Article  PubMed  CAS  Google Scholar 

  2. Erspamer, V., Melchiorri, P., Broccardo, M., Erspamer, G.F., Falaschi, P., Improta, G., Negri, L., and Renda, T. (1981). The braingut-skin triangle: New peptides. Peptides 2 (Suppl. 2) 7–16

    Article  PubMed  CAS  Google Scholar 

  3. Suchanek, G., and Kreil, G. 1977 Translation of melittin mes- senger RNA in vitro yields a product terminating with glutaminylglycine rather than with glutaaninamide. Proc. Natl. Acad. Sci. U.S.A. 74, 975–978

    Article  PubMed  CAS  Google Scholar 

  4. Solcia, E., Capella, C. Buffa, R., Usellini, L., Fiacca, R., and Sessa, F. (1981) Endocrine cells of the digestive system. In: Johnson, L.R. (ed.). Physiology of the Gastrointestinal Tract vol. 1 pp. 39–58. New York: Raven Press )

    Google Scholar 

  5. Jessen, K.R. Polak, J.M., Van Noortden, Blown, S.R., and Burnstock, G. (1980). Peptide-containing neurones connect the two ganglionated plexuses of the enteric nervous system. Nature (Lord.). 283: 391–393

    Article  CAS  Google Scholar 

  6. Lee, K.Y., Chey, W.Y., Tai, H.H., and Yajima, H. (1978). RadioimRnnoassay of motilin. Validation and studies on the relationship between plasma motilin and interdigestive myoelectric activity of the duodenum of dog. Am. J. Dig. Dis. 23, 789–795

    Article  PubMed  CAS  Google Scholar 

  7. Janssens, J., Hellemans, J., Adrian, T.E., Blown, S.R., Peeters, T.L., Christofides, N. and Vantrappen, G.R. (1982). Pancreatic po-lypeptide is not involved in the regulation of the migrating motor complex in man. Regulatory Peptides 3, 41–49

    Article  PubMed  CAS  Google Scholar 

  8. Peeters, T.L., Janssens, J., Vantrappen, G.R. (1983). Somatostatin and the interdigestive migrating motor complex in man. Regulatory Peptides 5, 209–217

    Article  PubMed  CAS  Google Scholar 

  9. Chey, W.Y., and Lee, R.Y. (1980). Motilin. Clinics in G-antroenterol 9, (3), 645–656

    CAS  Google Scholar 

  10. Lee, K.Y., Kim, M.S., and Chey, W.Y. (1980). Effects of a meal and gut hormones on plasma motilin and duodenal motility in dog. Am. J. Physiol. 238, G280–G283

    PubMed  CAS  Google Scholar 

  11. Walsh, J.H. (1981) Gastrointestinal hormones and peptides. In: Johnson, L.R. (ed.). Physiology of the Gastrointestinal Tract vol. 1. pp. 59–144 ( New York: Raven Press )

    Google Scholar 

  12. Creutzfeldt, W., Ebert, R., Nauck, M., Ste, F. (1983). Disturbances of the entera-insular axis. Scand. J. Gastroent. 18 (Suppl. 82), 111–119

    CAS  Google Scholar 

  13. Go, V.L.W., and Miller, L.J. (1983). The role of gastrointestinal hormones in the control of postprandial and interdigestive gastrointestinal function. Scand. J. Gastroent. 18 (Suppl. 82), 135–142

    CAS  Google Scholar 

  14. Grossman, M.T. (1977). Physiological effects of gastrointestinal hormones. Fed. Proc. 36, 1930

    Google Scholar 

  15. Konturek, S.J., Thor, P., Krol, R. Dembinski, A., and Schally, A. V. (1980) Influence of n~ethionine-enkephalin and morphine on myoelectric activity of small bowel. Am. J. Physiol. 238: G384–G389

    PubMed  CAS  Google Scholar 

  16. Erckenbrecht, J., Caspary, J., Körner, M.M., Berges, W., and Wien-beck, J. (1982). The inhibiting effect of pentagastrin on interdigestive small bowel motility is antagonized by proglumide. Gastroenterology 82, 1050

    Google Scholar 

  17. Chey, W.Y., Kim, M.S., Lee, K.Y., and Chang, T.M. (1979). Effect of rabbit antisecretin serum on postprandial pancreatic secretion in dogs. Gastroenterology 77, 1268–1275

    PubMed  CAS  Google Scholar 

  18. Lee, K.Y., Chang, T.M., and Chey, W.Y. (1983) Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in dog. Am. J. Physiol. (in press)

    Google Scholar 

  19. Sundler, P. Hakanson, R., Leander, S. (1980). Peptidergic nervous systems in the gut. Clinics in Gastroenterology 9 (3), 517–544

    PubMed  CAS  Google Scholar 

  20. Boldyreff, W.N. (1905). Le travail periodique de l’appareil digestif endehors de la digestion. Arch. Des. Sci. Biol. 11, 1–157

    Google Scholar 

  21. Szurszewski, J.H. (1969). A migrating electric complex of the canine small intestine. Am. J. Physiol. 217, 1757–1763

    PubMed  CAS  Google Scholar 

  22. Vantrappen, G.R., Janssens, J., Hellemans, J., and Ghoos, Y. (1977). The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J. Clin. Invest. 59, 1158–1166

    Article  PubMed  CAS  Google Scholar 

  23. Carlson, G.M., Bedi, B.S. and Code, C.F. (1972). Mechanism of propagation of intestinal interdigestive myoelectric complex. Am. J. Physiol. 222, 1027–1030

    PubMed  CAS  Google Scholar 

  24. Code, C.F., and Marlett, J.A. (1975). The interdigestive myoelectric complex of the stomach and small bowel of dogs. J. Physiol. (Land.) 246, 298–309

    Google Scholar 

  25. Schlegel, J.F., and Code, C.F. (1975). The gastric peristalsis of the interdigestive housekeeper. In: Vantrappen, G. (ed.). Proceedings of the Fifth International Symposium on Gastrointestinal Nbtility pp. 321–328. ( Herentals: Typoff Press )

    Google Scholar 

  26. Weisbrodt, N.W., Copeland, E.M., Thor, P.J. (1976). The myoelectric activity of the small intestine of the dog during total parenteral nutrition. Proc. Soc. Exp. Biol. Med. 153, 121–124

    PubMed  CAS  Google Scholar 

  27. Bueno, L. and Ruckebusch, Y. (1978). Migrating myoelectric complexes: disruption, enhancement and disorganisation. In: Duthie, H. (ed.). Gastrointestinal Motility in Health and Disease pp. 83–91. ( Lancaster: MI?, Press )

    Google Scholar 

  28. Boldyreff, W. (1911). Einige neue Seiten der Tatigkeit des Pancreas. Ergab. der Physiol. 11, 121–217

    Article  Google Scholar 

  29. Hoelzel, F. (1925). The relation between the secretory and motor activity in the fasting stanach (man). Am. J. Physiol. 73, 463–469

    Google Scholar 

  30. Vantrappen, G.R., Peeters, T.L., and Janssens, J. (1379). The secretory component of the interdigestive migrating motor complex in man. Scand. J. Gastroent. 14, 663–667

    Article  Google Scholar 

  31. Kaene, F.B., DiMagno, E.P., Dozois, R.R., and Go, V.L.W. (1980). Relationship among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma-pancreatic polypeptide and motilin. Gastroenterology 78, 310–316

    Google Scholar 

  32. Keene, F.B., DiMagno, E.P., and Malagelada, J.R. (1981). Duodenogastric reflux in humans: Its relationship to fasting antroduodenal motility and gastric, pancreatic and biliary secretion. Gastroenterology 81, 726–731

    Google Scholar 

  33. Brown, J.C., Mutt, V., and Dryburgh, J.R. (1971). The further purification of motilin, a gastric motor activity stimulating polypeptide from the mucosa of the small intestine in hogs. Can. J. Physiol. Pharmacol. 48, 339–405

    Google Scholar 

  34. Itoh, Z., Honda, R., Hiwatashi, K., Takeuchi, S., Aizawa, I., Takayanagi, R., and Conch, E.F. (1976). motilin-induced mechanical activity in the canine alimentary tract. Scand. J. Gastroent. 11 (Suppl. 39) 93–110

    Google Scholar 

  35. Wingate, D.L., Ruppin, H., Green, W.E.R., Thompson, H.H., Damchke,W., Wunsch, E., Demling, L., and Ritchie, H.D. (1976). Motilin-induced electrical activity in the canine gastrointestinal tract. Scand. J. Gastroent. 11 (Suppl. 39), 111–118

    CAS  Google Scholar 

  36. Konturek, S.J., Dembinski, A., Krol, R., and Wünsch, E. (1976). Effect of motilin on gastric and pancreatic secretion in dogs. Scand. J. Gastroent. 11, 57760

    Google Scholar 

  37. Itoh, Z., Takeuchi, S., Aizawa, I., Mari, K., Taminato, T., Sei-no, Y., Inaira, H., and Yanaihara, N. (1978). Changes in plasma moti-lin concentration and gastrointestinal contractile activity in conscious dogs. Am. J. Dig. Dis. 23, 929–935

    Article  PubMed  CAS  Google Scholar 

  38. Hall, K.E., Diamant, W.E., El-Sharkaway, T.Y. and Greenberg, G.R. (1953). Effects of pancreatic polypeptide on canine migrating motor complex and plasma motilin. Am. J. Physiol. 245, G178–G185

    Google Scholar 

  39. Wingate, D.L. (1983) The small intestine. In: Christensen, J., and Wingate, D.L. (ed). A Guide to Gastrointestinal Motility. pp. 128–156. ( Bristol: Wright. PSG )

    Google Scholar 

  40. Sara, S., Stoddard, C., Belbeck, L., and McWade, D. (1981). Intrinsic nervous control of migrating myoelectric complexes. Am. J. Physiol. 241, G16–G23

    Google Scholar 

  41. Thor, P., Krol, R., Konturek, S.J., Coy, D.H. and Schally, A.V. (1978). Effect of sanatostatin on myoelectric activity of small bowel. Am. J. Physiol. 235, E249–254

    PubMed  CAS  Google Scholar 

  42. Thor, P.J., Sendur, R., and Kcnturek, S.J. (1982). Influence of substance P on myoelectric activity of the small bowel. Am. J. Physiol. 243, G493–496

    PubMed  CAS  Google Scholar 

  43. Sarna, S., Condon, R.E., and Cowles, W. (1983). Morphine versus motilin in the initiation of migrating myoelectric complexes. Am. J. Physiol. 245, G217–G220

    PubMed  CAS  Google Scholar 

  44. Poitras, P., Steinbach, J.H., Van Deventer, G., Code, C.F., and Walsh, J.H. (1980). Motilin-independent ectopic fronts of the inter-digestive myoelectric complex in dogs. Am. J. Physiol. 239, G215–G220

    PubMed  CAS  Google Scholar 

  45. Lorber, S.H., Kamarav, S.A., and Shay, H. (1950). Effect of sham-feeding on gastric motor activity of the dog. Am. J. Physiol. 162, 447–451

    PubMed  CAS  Google Scholar 

  46. Preshaw, R.M., and Knauf, R.S. (1966). The effect of sham-feeding on the secretion and motility of canine duodenal pouches. Gastroenterology 51, 193–199

    PubMed  CAS  Google Scholar 

  47. Steinbach, J.H., and Code, C.F. (1980). Increase in the period of the interdigestive myoelectric complex (IIMOC) with anticipation of feeding. In: Christensen, J. (ed.). Gastrointestinal Motility. pp. 247–252. ( New York: Raven Press )

    Google Scholar 

  48. Defilippi, C., and Valenzuela, E. (1981). Sham-feeding disrupts the interdigestive motility complex in man. Scand. J. agtroent. 16, 977–979

    Article  CAS  Google Scholar 

  49. Peeters, T.L. Vantrappen, G., and Janssens, J. (1983). Sham-feeding amplifies the secretory component of interdigestive activity. Gastroenterology 84, 1272

    Google Scholar 

  50. Thar, P., Sendur, R., Konturek, S.J. (1982). Effect of sham-feeding and moscarinic receptors on myoelectric activity of the small intestine in the dog. Gastroenterology 82, 1197

    Google Scholar 

  51. Weisbrodt, N.W., Copeland, E.M., Thor, P., Muk1opadhyay, A.K., and Johnson, L.R. (1976). Nervous and humoral factors which influence the fasted patterns of intestinal myoelectric activity. In: Vantrappen, G. (ed.). Proceedings of the 5th International Symposium on Gastrointestinal Motility pp. 82–87. ( Herentals: Typoff Press )

    Google Scholar 

  52. Chang, J.C., Danchel, J., Sara, P., Angel, F., Bouchet, P., Lambert, A., and Grenier, J.F. (1978). Specific effects of different food components on intestinal motility. Eur. Surq. Res. 10, 425–432

    Article  Google Scholar 

  53. Weisbrodt, N.W., Moore, E., Marley, R., Copeland, E.M., and Johnson, L.R. (1974). Effects of pentagstrin on the myoelectric activity of the small intestine. Am. J. Physiol. 227, 425–429

    PubMed  CAS  Google Scholar 

  54. Mukhopadhyay, A.K., Thor, P., Copeland, E.M., Johnson, L.R., and Weisbrodt, N.W. (1977). Effect of cholecystokinin on myoelectric activity of small intestine of the dog. Am. J. Physiol. 2321, E 44–E47

    Google Scholar 

  55. Mukhopadhyay, A.K., Johnson, L.R., Copeland, E.M., and Weisbrodt, N. (1975). Effect of matin on electric activity of small intestine. Am. J. Physiol. 229, 484–488

    PubMed  CAS  Google Scholar 

  56. Bueno, L., and Ruckebusch, M. (1976). Insulin and jejunal electrical activity in dogs and sheep. Am. J. Physiol. 230, 1539–1544

    Google Scholar 

  57. Thanes, P.A., Schang, J.C., Kelly, K.A., and Go, V.L.W. (1980). Can endogenous gastrin inhibit canine interdigestive gastric motility. Gastroenterology 78, 716–721

    Google Scholar 

  58. Wingate, D.L., Pearce, P.A., Hutton, M., and Thompson, H.H. (1978). Quantitative comparison of the effects of cholecystokinin, secretin and pentagastrin on gastrointestinal myoelectric activity in the conscious dog. Gut 19, 593–601

    Article  PubMed  CAS  Google Scholar 

  59. Thor, K., Rosell, S., Rokaeus, A., and Kager, L. (1982). (G1u4)Neurotensin changes the motility pattern of the duodenum and proximal.74rnun from a fasting-type to a fed-type. Gastroenterology 83, 569–574

    Google Scholar 

  60. Thor, P.J., Konturek, J.W., Sendur, R., and Konturek, S.J. Comparison of neurotensin and fat on myoelectric activity pattern of the small bowel (in this issue)

    Google Scholar 

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© 1984 MTP Press Limited

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Konturek, S.J. (1984). Lecture. In: Roman, C. (eds) Gastrointestinal Motility. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9352-1_97

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  • DOI: https://doi.org/10.1007/978-94-010-9352-1_97

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9354-5

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