Abstract
The HCAR was established in 1962 as the first national-based registry in the world (I), after the greatest tragedy of human teratology, the thalidomide-Contergan catastrophe. After a pilot period, the HCAR started to work according to the internationally recommended principles under my direction as part of the Department of Human Genetics and Teratology, National Institute of Public Health (NIPH) in 1980 (Fig. 1.1). The HCAR had a budget from the Ministry of Health for the salary of the staff, computer work, printing, and mailing costs. Extra projects needed special funds.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Botto LD, Olney RS, Erickson JD. Vitamin supplements and the risk for congenital anomalies other than neural tube defects. Am J Med Genet C 2004; 125C: 12–21.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 7th ed. Lippincott Williams and Wilkins, Philadelphia, 2005.
Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004.
Friedman JM, Polifka JE. The Effects of Drugs on the Fetus and Nursing Infant. Johns Hopkins Univ Press, Baltimore, 2000.
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75–84.
Hernandez-Diaz S, Werler MM, Walker AM, Mitchel AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000; 343: 1608–1914.
Iams JD, Creasy RK. Preterm labor and delivery. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004. pp. 623–661.
Meadow KJ, Baker GA, Browning N et al. Cognitive function at 3 years of age after fetal exposure to antieplileptic drugs. N Engl J Med 2009; 360: 1597–1605.
Nishimura H, Yamamura H. Comparison between man and some other mammals of normal and abnormal developmental processes. In: Nishimura H, Miller JR (eds.) Method of Teratological Studies in Experimental Animals and Man. Igaku Shoin, Tokyo 1969. pp. 223–240.
Opitz JM. The developmental field concept in clinical genetics. J Pediatr 1982; 101: 803–809.
Perneger TV. What’s wrong with Bonferroni adjustment. Br Med J 1998; 316: 1236–1238.
Resnik R, Creasy RK. Intrauterine growth restriction. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004. pp. 495–512.
Shaffer JP. Multiple hypothesis testing. Ann Rev Psychol 1995; 46: 561–584.
Shepard TH, Lemire RJ. Catalog of Teratogenic Agents. 11th ed. Johns Hopkins University Press, Baltimore, 2004.
Smith DW. Classification, nomenclature and naming of morphologic defects. J Pediatr 1975; 87: 162–164.
Spranger L, Benirschke K, Hall J et al. Errors of morphogenesis concept and terms. J Pediatr 1982; 100: 160–165.
Yoon PW, Rasmussen SA, Lynberg, MC et al. The national birth defects prevention study. Public Health Rep 2001; 116 (Suppl. 1): 32–40.
Own Publications
Czeizel A. First 25 years of the Hungarian Congenital Abnormality Registry. Teratology 1997; 55: 299–305.
Czeizel AE, Telegdi L, Tusnady G. Multiple Congenital Abnormalities. Akadémiai Kiadó, Budapest, 1988.
Czeizel AE, Kovács M, Kiss P, Méhes K, Szabó L, Oláh É, Kosztolányi G, Szemere G, Kovács H, Fekete G. Nationwide evaluation of multiple congenital abnormalities in Hungary. Genetic Epid 1988; 5: 183–202.
Czeizel A. Schisis association. Am J Med Genet 1981; 10: 25–35.
Czeizel AE, Ludányi I. VACTERL association. Acta Morph Hung 1984; 32: 75–79.
Pazonyi I, Bod M, Czeizel A. Postural associations. Acta Paediatr Acad Sci Hung 1983; 23: 431–445.
Czeizel A. Genital anomalies of males: GAM-complex. Eur J Pediatr 1987; 146: 181–183.
Kis-Varga A, Rudas T, Czeizel A. A new approach to germinal mutation surveillance: pair-wise evaluation of component elements in unidentified multiple congenital abnormalities. Mutat Res 1990; 238: 87–97.
Czeizel AE, The activities of the Hungarian Centre for Congenital Anomaly Control. WHO Stat Quart Rep 1988; 41: 219–227.
Czeizel A. The ethical issues of the postmarketing surveillance of drug teratogenicity in Hungary. Pharmacoepid Drug Saf 2001; 10: 635–639.
Czeizel AE, Intõdy Zs, Modell B. What proportion of congenital abnormalities can be prevented? Br Med J 1993; 306: 499–503.
Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984.
Czeizel A. Epidemiological studies of congenital abnormalities in Hungary. In: Kalter H (ed.) Issues and Reviews in Teratology 1993; 6: 85–124.
Czeizel AE, Petik D, Vargha P. Validation studies of drug exposures in pregnant women. Pharmacoepid Drug Saf 2003; 12: 409–416.
Czeizel AE, Vargha P. Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gynecol 2004; 191: 790–794.
Czeizel AE, Petik D, Puhó E. Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Centr Eur J Publ Health 2004; 12: 179–183.
Czeizel AE, Gidai J, Petik D, Timmermann G, Puho H. Self-poisoning during pregnancy as a model for teratogenic estimation of drugs. Toxic Indust Health 2008; 24: 11–28.
Czeizel AE, Tóth M. Birth weight, gestational age and medications during pregnancy. Int J Gynecol Obstet 1998; 60: 245–249.
Czeizel AE, Pazonyi I. Increase of upper-limb-reduction deformities in Hungary. Lancet 1976; 1: 701.
Czeizel AE, Keller S, Bod M. An aetiological evaluation of increased occurrence of congenital limb reduction abnormalities in Hungary, 1975–1978. Int J Epidemiol 1983; 12: 442–449.
Czeizel AE, Elerk Cs, Gundy S, Métneki J, Nemes E, Reis K, Sperling K, Timár L, Tusnády G. Virágh Z. Environmental trichlorfon and cluster of congenital abnormalities. Lancet 1993; 34: 539–542.
Czeizel AE, Rockenbauer M, Siffel Cs, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 2001; 63: 176–185.
Czeizel A. The role of pharmacoepidemiology in pharmacovigilance: rational drug use in pregnancy. Pharmacoepid Drug Saf 1999; 8: 555–561.
Czeizel A. Drug use during pregnancy in Hungary. Acta Med Hung 1989; 46: 53–62.
Czeizel AE, Rácz J. Evaluation of drug intake during pregnancy in the Hungarian Case-Control Surveillance of Congenital Anomalies. Teratology 1990; 42: 505–512.
Czeizel A. Drug exposure in pregnant women. Lupus 2004; 13: 740–745.
Bánhidy F, Lowry RB, Czeizel A. Risk and benefit of drug use during pregnancy. Int J Med Sci 2005; 2: 100–106.
Czeizel A. The estimation of human teratogenic/fetotoxic risk of exposures to drugs on the Hunagraian experience: a critical evaluation of clinical and epidemiological models of human teratology. Exp Opin Drug Saf 2009; 8: 283–303.
Czeizel AE, Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med 1970; 24: 205–222.
Czeizel A. Anencephaly-spina bifida cystica. In: Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984. pp. 49–83.
Medveczky E, Puho E, Czeizel A. An evaluation of maternal illnesses in the origin of neural-tube defects. Arch Gynecol Obstet 2004; 270: 244–251.
Medveczky E. Puho E. Parental employment and neural-tube defects and folic acid/multivitamin supplementation in Hungary. Eur J Obstet Gynecol Reprod Biol 2004; 115: 178–184.
Medveczky E, Puho E, Czeizel A. The use of drugs in mothers of offspring with neural-tube defects. Pharmacoepid Drug Saf 2004; 13: 443–455.
Czeizel AE, Tusnády G. An epidemiological study of cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1971; 21: 17–38.
Czeizel AE, Tusnády G. A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1972; 22: 405–416.
Sárközi A, Wyszynski DF, Czeizel A. Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Registry. BMC Oral Health 2005; 5: 4–18.
Wyszinsky DE, Sárközy A, Vargha P, Czeizel A. Birth weight and gestational age of newborns with cleft lip with or without cleft palate and with isolated cleft palate. J Clin Pediat Dent 2003; 27: 185–190.
Czeizel AE, Sárközy A, Wyszinsky D. Protective effect of hyperemesis gravidarum for non-syndromic oral cleft. Obstet Gynecol 2003; 101: 737–744.
Wyszynski DF, Sárközi A, Czeizel A. Oral clefts with associated anomalies: methodological issues. Cleft Palate-Craniofacial J 2006; 43: 1–6.
Métneki J, Puho E, Czeizel A. Maternal disease and isolated orofacial clefts in Hungary. Birth Defects Res A 2005; 73: 617–623.
Puho HE, Métneki J, Czeizel A. Drug treatment during pregnancy and isolated orofacial clefts in Hungary. Cleft Palate-Craniofacial J 2007; 44: 194–202.
Puho E, Métneki J, Czeizel A. Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Publ Health 2005; 13: 144–148.
Szendrey T, Danyi G, Czeizel A. Etiological study on isolated esophageal atresia. Hum Genet 1985; 70: 51–58.
Czeizel A. Birthweight distribution in congenital pyloric stenosis. Arch Dis Child 1972; 47: 978–980.
Czeizel A. Congenital hypertrophic pyloric stenosis. In: Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984. pp. 197–120.
Czeizel AE, Toth J, Czvenits E. Increased birth prevalence of isolated hypospadias in Hungary. Acta Paediatr Hung 1986; 27: 329–337.
Czeizel AE, Toth J, Erödi E. Aetiological study of hypospadias in Hungary. Hum Hered 1979; 29: 166–171.
Czeizel AE, Toth J. A correlation between the birth prevalence of isolated hypospadias and parental subfertility. Teratology 1990; 41: 167–172.
Fritz G, Czeizel A. Abnormal sperm morphology and function in the fathers of hypospadiacs. J Reprod Fertil 1996; 106: 63–66.
Czeizel AE, Erődi É, Toth J. An epidemiological study on undescended testis. J Urol 1981; 126: 524–527.
Czeizel AE, Erődi É, Toth J. Genetics of undescended testis. J Urol 1981; 126: 528–529.
Czeizel AE, Vitéz M. Etiological study of omphalocele. Hum Genet 1981; 58: 390–395.
Abdel-Salam GMH, Vogt G, Halász A, Czeizel A. Microcephaly with normal intelligence and chorioretinopathy. Ophthal Genet 1999; 20: 259–264.
Czeizel AE, Abdel-Salam GMH. A case-control etiologic study of microcephaly. Epidemiology 2000; 11: 1–5.
Abdel-Salam GMH, Svékus A, Pelle Z. Microcephaly, microphthalmia, congenital cataract, with calcification of the basal ganglia: MCA/MR syndrome. Genet Counsel 2000; 4: 391–397.
Abdel-Salam GMH, Vogt G, Czeizel A. Microcephaly with chorioretinal dysplasia: characteristic facial features. Am J Med Genet 2000; 95: 513–515.
Abdel-Salam GMH, Halász AA, Czeizel A. Association of epilepsy with different groups of microcephaly. Develop Med Child Neurol 2000; 42: 760–767.
Abdel-Salam GMH, Gyenis G, Czeizel A. Antropometric craniofacial pattern profiles in microcephaly. Anthrop Rev 2002; 65: 65–74.
Vogt G, Horvath-Puho E, Czeizel A. A population-based case-control study of isolated primary congenital glaucoma. Am J Med Genet 2006; 140A: 1148–1155.
Vogt G, Szunyogh M, Czeizel A. Birth characteristics of different ocular congenital abnormalities in Hungary. Ophthalmic Epidemiology 2006; 13: 159–166.
Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated ocular coloboma. Ophthalmic Epidemiol 2005; 12: 191–197.
Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated congenital cataract. Birth Defects Res A 2005; 73: 997–1005.
Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated anophthalmia and microphthalmia. Eur J Epidemiol 2005; 20: 939–946.
Puhó HE, Vogt G, Czeizel A. Maternal demographic and socioeconomic characteristics of live-born infants with isolated ocular congenital abnormalites. Ophthal Epid 2008; 15: 257–263.
Czeizel AE, Kamarás J, Balogh Ö, Szentpéteri J. Incidence of congenital heart defects in Budapest. Acta Paediatr Acad Sci Hung 1972; 13: 191–202.
Mészáros M, Nagy A, Czeizel A. Incidence of congenital heart disease in Hungary. Hum Hered 1975; 25: 513–519.
Mészáros M, Czeizel A. Point prevalence at birth of ventricular septal defect in Hungary. Acta Paediatr Acad Sci Hung 1978; 19: 51–54.
Czeizel AE, Mészáros M. Two family studies of children with ventricular septal defects. Eur J Paediatr 1981; 136: 81–85.
Mészáros M, Czeizel A. ECG-conduction disturbance in the first-degree relatives of children with ventricular septal defect. Clin Genet 1981; 19: 298–301.
Czeizel AE, Pornoi A, Péterffy E, Tarczal E. Study of children of parents operated on for congenital cardiovascular malformation. Br Heart J 1982; 47: 290–293.
Bellyei Á, Czeizel A. A higher incidence of congenital structural talipes equinovarus in gypsies. Hum Hered 1983; 33: 58–59.
Czeizel AE, Bellyei Á, Kránicz J, Mocsai L, Tasnády G. Confirmation of multifactorial threshold model for congenital structural talipes equinovarus. J Med Genet 1981; 19: 99–100.
Czeizel AE, Evans JA, Kodaj I, Lenz W. Congenital Limb Deficiencies in Hungary. Genetic and Teratologic Epidemiological Studies. Akadémiai Kiadó, Budapest, 1994.
Czeizel AE, Kodaj I, Lenz W. Smoking during pregnancy and congenital limb deficiency. Br Med J 1994; 308: 1473–1476.
Czeizel AE, Kovács M. A family study of congenital diaphragmatic defects. Am J Med Genet 1985; 21: 105–115.
Fraser FC, Czeizel AE, Hanson C. Increased frequency of neural tube defects in sibs of children with other malformations. Lancet 1982; 2: 144–145.
Puho HE, Czeizel AE, Ács N, Bánhidy F. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complicationbs in their mothers depending on the number of component defects. Population-based case-control study. Cong Anom (Kyoto) 2006; 48: 126–136.
Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT, EuroMAP group et al. Recall bias in a case-control study on the use of medicine during pregnancy. Epidemiology 2001; 12: 401–406.
Czeizel A. The first trimester concept is outdated. Cong Anom (Kyoto) 2001; 41: 204.
Czeizel AE, Puho HE, Ács N, Bánhidy F. The use of specified critical periods of different congenital abnormalities instead of the first trimester concept. Birth Defects Res A 2008; 82: 139–146.
Czeizel A. Specified critical period of different congenital abnormalities: a new approach for human teratology. Cong Anom (Kyoto) 2008; 48: 103–109.
Gönczi L, Czeizel A. Integrating smoking cessation into periconceptional care. Tobacco Control 1996; 5: 160.
Christian MS, Czeizel A. Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant women. Toxic Indust Health 2008. 24: 5–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Ács, N., Bánhidy, F.G., Czeizel, A.E. (2010). The Hungarian Congenital Abnormality Registry (HCAR). In: Ács, N., Bánhidy, F., Czeizel, A. (eds) Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8620-4_1
Download citation
DOI: https://doi.org/10.1007/978-90-481-8620-4_1
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-8619-8
Online ISBN: 978-90-481-8620-4
eBook Packages: MedicineMedicine (R0)