Skip to main content

Abstract

The HCAR was established in 1962 as the first national-based registry in the world (I), after the greatest tragedy of human teratology, the thalidomide-Contergan catastrophe. After a pilot period, the HCAR started to work according to the internationally recommended principles under my direction as part of the Department of Human Genetics and Teratology, National Institute of Public Health (NIPH) in 1980 (Fig. 1.1). The HCAR had a budget from the Ministry of Health for the salary of the staff, computer work, printing, and mailing costs. Extra projects needed special funds.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Botto LD, Olney RS, Erickson JD. Vitamin supplements and the risk for congenital anomalies other than neural tube defects. Am J Med Genet C 2004; 125C: 12–21.

    Article  Google Scholar 

  • Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 7th ed. Lippincott Williams and Wilkins, Philadelphia, 2005.

    Google Scholar 

  • Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004.

    Google Scholar 

  • Friedman JM, Polifka JE. The Effects of Drugs on the Fetus and Nursing Infant. Johns Hopkins Univ Press, Baltimore, 2000.

    Google Scholar 

  • Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75–84.

    Article  PubMed  Google Scholar 

  • Hernandez-Diaz S, Werler MM, Walker AM, Mitchel AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000; 343: 1608–1914.

    Article  PubMed  CAS  Google Scholar 

  • Iams JD, Creasy RK. Preterm labor and delivery. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004. pp. 623–661.

    Google Scholar 

  • Meadow KJ, Baker GA, Browning N et al. Cognitive function at 3 years of age after fetal exposure to antieplileptic drugs. N Engl J Med 2009; 360: 1597–1605.

    Article  Google Scholar 

  • Nishimura H, Yamamura H. Comparison between man and some other mammals of normal and abnormal developmental processes. In: Nishimura H, Miller JR (eds.) Method of Teratological Studies in Experimental Animals and Man. Igaku Shoin, Tokyo 1969. pp. 223–240.

    Google Scholar 

  • Opitz JM. The developmental field concept in clinical genetics. J Pediatr 1982; 101: 803–809.

    Google Scholar 

  • Perneger TV. What’s wrong with Bonferroni adjustment. Br Med J 1998; 316: 1236–1238.

    Article  CAS  Google Scholar 

  • Resnik R, Creasy RK. Intrauterine growth restriction. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. Principles and Practice. 5th ed. Saunders, Philadelphia, 2004. pp. 495–512.

    Google Scholar 

  • Shaffer JP. Multiple hypothesis testing. Ann Rev Psychol 1995; 46: 561–584.

    Article  Google Scholar 

  • Shepard TH, Lemire RJ. Catalog of Teratogenic Agents. 11th ed. Johns Hopkins University Press, Baltimore, 2004.

    Google Scholar 

  • Smith DW. Classification, nomenclature and naming of morphologic defects. J Pediatr 1975; 87: 162–164.

    Article  PubMed  CAS  Google Scholar 

  • Spranger L, Benirschke K, Hall J et al. Errors of morphogenesis concept and terms. J Pediatr 1982; 100: 160–165.

    Article  PubMed  CAS  Google Scholar 

  • Yoon PW, Rasmussen SA, Lynberg, MC et al. The national birth defects prevention study. Public Health Rep 2001; 116 (Suppl. 1): 32–40.

    Article  PubMed  Google Scholar 

Own Publications

  1. Czeizel A. First 25 years of the Hungarian Congenital Abnormality Registry. Teratology 1997; 55: 299–305.

    Article  PubMed  CAS  Google Scholar 

  2. Czeizel AE, Telegdi L, Tusnady G. Multiple Congenital Abnormalities. Akadémiai Kiadó, Budapest, 1988.

    Google Scholar 

  3. Czeizel AE, Kovács M, Kiss P, Méhes K, Szabó L, Oláh É, Kosztolányi G, Szemere G, Kovács H, Fekete G. Nationwide evaluation of multiple congenital abnormalities in Hungary. Genetic Epid 1988; 5: 183–202.

    Article  CAS  Google Scholar 

  4. Czeizel A. Schisis association. Am J Med Genet 1981; 10: 25–35.

    Article  PubMed  CAS  Google Scholar 

  5. Czeizel AE, Ludányi I. VACTERL association. Acta Morph Hung 1984; 32: 75–79.

    CAS  Google Scholar 

  6. Pazonyi I, Bod M, Czeizel A. Postural associations. Acta Paediatr Acad Sci Hung 1983; 23: 431–445.

    Google Scholar 

  7. Czeizel A. Genital anomalies of males: GAM-complex. Eur J Pediatr 1987; 146: 181–183.

    Article  PubMed  CAS  Google Scholar 

  8. Kis-Varga A, Rudas T, Czeizel A. A new approach to germinal mutation surveillance: pair-wise evaluation of component elements in unidentified multiple congenital abnormalities. Mutat Res 1990; 238: 87–97.

    Article  PubMed  CAS  Google Scholar 

  9. Czeizel AE, The activities of the Hungarian Centre for Congenital Anomaly Control. WHO Stat Quart Rep 1988; 41: 219–227.

    CAS  Google Scholar 

  10. Czeizel A. The ethical issues of the postmarketing surveillance of drug teratogenicity in Hungary. Pharmacoepid Drug Saf 2001; 10: 635–639.

    Article  CAS  Google Scholar 

  11. Czeizel AE, Intõdy Zs, Modell B. What proportion of congenital abnormalities can be prevented? Br Med J 1993; 306: 499–503.

    Article  CAS  Google Scholar 

  12. Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984.

    Google Scholar 

  13. Czeizel A. Epidemiological studies of congenital abnormalities in Hungary. In: Kalter H (ed.) Issues and Reviews in Teratology 1993; 6: 85–124.

    Google Scholar 

  14. Czeizel AE, Petik D, Vargha P. Validation studies of drug exposures in pregnant women. Pharmacoepid Drug Saf 2003; 12: 409–416.

    Article  CAS  Google Scholar 

  15. Czeizel AE, Vargha P. Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gynecol 2004; 191: 790–794.

    Article  PubMed  CAS  Google Scholar 

  16. Czeizel AE, Petik D, Puhó E. Smoking and alcohol drinking during pregnancy: the validity of retrospective maternal self-reported information. Centr Eur J Publ Health 2004; 12: 179–183.

    CAS  Google Scholar 

  17. Czeizel AE, Gidai J, Petik D, Timmermann G, Puho H. Self-poisoning during pregnancy as a model for teratogenic estimation of drugs. Toxic Indust Health 2008; 24: 11–28.

    Article  CAS  Google Scholar 

  18. Czeizel AE, Tóth M. Birth weight, gestational age and medications during pregnancy. Int J Gynecol Obstet 1998; 60: 245–249.

    Article  CAS  Google Scholar 

  19. Czeizel AE, Pazonyi I. Increase of upper-limb-reduction deformities in Hungary. Lancet 1976; 1: 701.

    Article  PubMed  CAS  Google Scholar 

  20. Czeizel AE, Keller S, Bod M. An aetiological evaluation of increased occurrence of congenital limb reduction abnormalities in Hungary, 1975–1978. Int J Epidemiol 1983; 12: 442–449.

    Article  Google Scholar 

  21. Czeizel AE, Elerk Cs, Gundy S, Métneki J, Nemes E, Reis K, Sperling K, Timár L, Tusnády G. Virágh Z. Environmental trichlorfon and cluster of congenital abnormalities. Lancet 1993; 34: 539–542.

    Article  Google Scholar 

  22. Czeizel AE, Rockenbauer M, Siffel Cs, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 2001; 63: 176–185.

    Article  PubMed  CAS  Google Scholar 

  23. Czeizel A. The role of pharmacoepidemiology in pharmacovigilance: rational drug use in pregnancy. Pharmacoepid Drug Saf 1999; 8: 555–561.

    Google Scholar 

  24. Czeizel A. Drug use during pregnancy in Hungary. Acta Med Hung 1989; 46: 53–62.

    PubMed  CAS  Google Scholar 

  25. Czeizel AE, Rácz J. Evaluation of drug intake during pregnancy in the Hungarian Case-Control Surveillance of Congenital Anomalies. Teratology 1990; 42: 505–512.

    Article  PubMed  CAS  Google Scholar 

  26. Czeizel A. Drug exposure in pregnant women. Lupus 2004; 13: 740–745.

    Article  PubMed  CAS  Google Scholar 

  27. Bánhidy F, Lowry RB, Czeizel A. Risk and benefit of drug use during pregnancy. Int J Med Sci 2005; 2: 100–106.

    Article  PubMed  Google Scholar 

  28. Czeizel A. The estimation of human teratogenic/fetotoxic risk of exposures to drugs on the Hunagraian experience: a critical evaluation of clinical and epidemiological models of human teratology. Exp Opin Drug Saf 2009; 8: 283–303.

    Article  CAS  Google Scholar 

  29. Czeizel AE, Révész C. Major malformations of the central nervous system in Hungary. Br J Prev Soc Med 1970; 24: 205–222.

    PubMed  CAS  Google Scholar 

  30. Czeizel A. Anencephaly-spina bifida cystica. In: Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984. pp. 49–83.

    Google Scholar 

  31. Medveczky E, Puho E, Czeizel A. An evaluation of maternal illnesses in the origin of neural-tube defects. Arch Gynecol Obstet 2004; 270: 244–251.

    Article  PubMed  Google Scholar 

  32. Medveczky E. Puho E. Parental employment and neural-tube defects and folic acid/multivitamin supplementation in Hungary. Eur J Obstet Gynecol Reprod Biol 2004; 115: 178–184.

    Article  PubMed  CAS  Google Scholar 

  33. Medveczky E, Puho E, Czeizel A. The use of drugs in mothers of offspring with neural-tube defects. Pharmacoepid Drug Saf 2004; 13: 443–455.

    Article  Google Scholar 

  34. Czeizel AE, Tusnády G. An epidemiological study of cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1971; 21: 17–38.

    Article  PubMed  CAS  Google Scholar 

  35. Czeizel AE, Tusnády G. A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary. Hum Hered 1972; 22: 405–416.

    Article  PubMed  CAS  Google Scholar 

  36. Sárközi A, Wyszynski DF, Czeizel A. Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Registry. BMC Oral Health 2005; 5: 4–18.

    Article  PubMed  Google Scholar 

  37. Wyszinsky DE, Sárközy A, Vargha P, Czeizel A. Birth weight and gestational age of newborns with cleft lip with or without cleft palate and with isolated cleft palate. J Clin Pediat Dent 2003; 27: 185–190.

    Google Scholar 

  38. Czeizel AE, Sárközy A, Wyszinsky D. Protective effect of hyperemesis gravidarum for non-syndromic oral cleft. Obstet Gynecol 2003; 101: 737–744.

    Article  PubMed  Google Scholar 

  39. Wyszynski DF, Sárközi A, Czeizel A. Oral clefts with associated anomalies: methodological issues. Cleft Palate-Craniofacial J 2006; 43: 1–6.

    Article  Google Scholar 

  40. Métneki J, Puho E, Czeizel A. Maternal disease and isolated orofacial clefts in Hungary. Birth Defects Res A 2005; 73: 617–623.

    Article  Google Scholar 

  41. Puho HE, Métneki J, Czeizel A. Drug treatment during pregnancy and isolated orofacial clefts in Hungary. Cleft Palate-Craniofacial J 2007; 44: 194–202.

    Article  Google Scholar 

  42. Puho E, Métneki J, Czeizel A. Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Publ Health 2005; 13: 144–148.

    Article  CAS  Google Scholar 

  43. Szendrey T, Danyi G, Czeizel A. Etiological study on isolated esophageal atresia. Hum Genet 1985; 70: 51–58.

    Article  PubMed  CAS  Google Scholar 

  44. Czeizel A. Birthweight distribution in congenital pyloric stenosis. Arch Dis Child 1972; 47: 978–980.

    Article  PubMed  CAS  Google Scholar 

  45. Czeizel A. Congenital hypertrophic pyloric stenosis. In: Czeizel AE, Tusnady G. Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary. Akadémiai Kiadó, Budapest, 1984. pp. 197–120.

    Google Scholar 

  46. Czeizel AE, Toth J, Czvenits E. Increased birth prevalence of isolated hypospadias in Hungary. Acta Paediatr Hung 1986; 27: 329–337.

    PubMed  CAS  Google Scholar 

  47. Czeizel AE, Toth J, Erödi E. Aetiological study of hypospadias in Hungary. Hum Hered 1979; 29: 166–171.

    Article  PubMed  CAS  Google Scholar 

  48. Czeizel AE, Toth J. A correlation between the birth prevalence of isolated hypospadias and parental subfertility. Teratology 1990; 41: 167–172.

    Article  Google Scholar 

  49. Fritz G, Czeizel A. Abnormal sperm morphology and function in the fathers of hypospadiacs. J Reprod Fertil 1996; 106: 63–66.

    Article  PubMed  CAS  Google Scholar 

  50. Czeizel AE, Erődi É, Toth J. An epidemiological study on undescended testis. J Urol 1981; 126: 524–527.

    PubMed  CAS  Google Scholar 

  51. Czeizel AE, Erődi É, Toth J. Genetics of undescended testis. J Urol 1981; 126: 528–529.

    PubMed  CAS  Google Scholar 

  52. Czeizel AE, Vitéz M. Etiological study of omphalocele. Hum Genet 1981; 58: 390–395.

    Article  PubMed  CAS  Google Scholar 

  53. Abdel-Salam GMH, Vogt G, Halász A, Czeizel A. Microcephaly with normal intelligence and chorioretinopathy. Ophthal Genet 1999; 20: 259–264.

    Article  PubMed  CAS  Google Scholar 

  54. Czeizel AE, Abdel-Salam GMH. A case-control etiologic study of microcephaly. Epidemiology 2000; 11: 1–5.

    Article  Google Scholar 

  55. Abdel-Salam GMH, Svékus A, Pelle Z. Microcephaly, microphthalmia, congenital cataract, with calcification of the basal ganglia: MCA/MR syndrome. Genet Counsel 2000; 4: 391–397.

    Google Scholar 

  56. Abdel-Salam GMH, Vogt G, Czeizel A. Microcephaly with chorioretinal dysplasia: characteristic facial features. Am J Med Genet 2000; 95: 513–515.

    Article  PubMed  CAS  Google Scholar 

  57. Abdel-Salam GMH, Halász AA, Czeizel A. Association of epilepsy with different groups of microcephaly. Develop Med Child Neurol 2000; 42: 760–767.

    Article  PubMed  CAS  Google Scholar 

  58. Abdel-Salam GMH, Gyenis G, Czeizel A. Antropometric craniofacial pattern profiles in microcephaly. Anthrop Rev 2002; 65: 65–74.

    Google Scholar 

  59. Vogt G, Horvath-Puho E, Czeizel A. A population-based case-control study of isolated primary congenital glaucoma. Am J Med Genet 2006; 140A: 1148–1155.

    Article  Google Scholar 

  60. Vogt G, Szunyogh M, Czeizel A. Birth characteristics of different ocular congenital abnormalities in Hungary. Ophthalmic Epidemiology 2006; 13: 159–166.

    Article  PubMed  Google Scholar 

  61. Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated ocular coloboma. Ophthalmic Epidemiol 2005; 12: 191–197.

    Article  PubMed  Google Scholar 

  62. Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated congenital cataract. Birth Defects Res A 2005; 73: 997–1005.

    Article  CAS  Google Scholar 

  63. Vogt G, Puhó E, Czeizel A. A population-based case-control study of isolated anophthalmia and microphthalmia. Eur J Epidemiol 2005; 20: 939–946.

    Article  PubMed  Google Scholar 

  64. Puhó HE, Vogt G, Czeizel A. Maternal demographic and socioeconomic characteristics of live-born infants with isolated ocular congenital abnormalites. Ophthal Epid 2008; 15: 257–263.

    Article  Google Scholar 

  65. Czeizel AE, Kamarás J, Balogh Ö, Szentpéteri J. Incidence of congenital heart defects in Budapest. Acta Paediatr Acad Sci Hung 1972; 13: 191–202.

    PubMed  CAS  Google Scholar 

  66. Mészáros M, Nagy A, Czeizel A. Incidence of congenital heart disease in Hungary. Hum Hered 1975; 25: 513–519.

    Article  PubMed  Google Scholar 

  67. Mészáros M, Czeizel A. Point prevalence at birth of ventricular septal defect in Hungary. Acta Paediatr Acad Sci Hung 1978; 19: 51–54.

    PubMed  Google Scholar 

  68. Czeizel AE, Mészáros M. Two family studies of children with ventricular septal defects. Eur J Paediatr 1981; 136: 81–85.

    Article  CAS  Google Scholar 

  69. Mészáros M, Czeizel A. ECG-conduction disturbance in the first-degree relatives of children with ventricular septal defect. Clin Genet 1981; 19: 298–301.

    Article  PubMed  Google Scholar 

  70. Czeizel AE, Pornoi A, Péterffy E, Tarczal E. Study of children of parents operated on for congenital cardiovascular malformation. Br Heart J 1982; 47: 290–293.

    Article  PubMed  CAS  Google Scholar 

  71. Bellyei Á, Czeizel A. A higher incidence of congenital structural talipes equinovarus in gypsies. Hum Hered 1983; 33: 58–59.

    Article  PubMed  CAS  Google Scholar 

  72. Czeizel AE, Bellyei Á, Kránicz J, Mocsai L, Tasnády G. Confirmation of multifactorial threshold model for congenital structural talipes equinovarus. J Med Genet 1981; 19: 99–100.

    Article  Google Scholar 

  73. Czeizel AE, Evans JA, Kodaj I, Lenz W. Congenital Limb Deficiencies in Hungary. Genetic and Teratologic Epidemiological Studies. Akadémiai Kiadó, Budapest, 1994.

    Google Scholar 

  74. Czeizel AE, Kodaj I, Lenz W. Smoking during pregnancy and congenital limb deficiency. Br Med J 1994; 308: 1473–1476.

    Article  CAS  Google Scholar 

  75. Czeizel AE, Kovács M. A family study of congenital diaphragmatic defects. Am J Med Genet 1985; 21: 105–115.

    Article  PubMed  CAS  Google Scholar 

  76. Fraser FC, Czeizel AE, Hanson C. Increased frequency of neural tube defects in sibs of children with other malformations. Lancet 1982; 2: 144–145.

    Article  PubMed  CAS  Google Scholar 

  77. Puho HE, Czeizel AE, Ács N, Bánhidy F. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complicationbs in their mothers depending on the number of component defects. Population-based case-control study. Cong Anom (Kyoto) 2006; 48: 126–136.

    Article  Google Scholar 

  78. Rockenbauer M, Olsen J, Czeizel AE, Pedersen L, Sorensen HT, EuroMAP group et al. Recall bias in a case-control study on the use of medicine during pregnancy. Epidemiology 2001; 12: 401–406.

    Article  Google Scholar 

  79. Czeizel A. The first trimester concept is outdated. Cong Anom (Kyoto) 2001; 41: 204.

    Article  Google Scholar 

  80. Czeizel AE, Puho HE, Ács N, Bánhidy F. The use of specified critical periods of different congenital abnormalities instead of the first trimester concept. Birth Defects Res A 2008; 82: 139–146.

    Article  CAS  Google Scholar 

  81. Czeizel A. Specified critical period of different congenital abnormalities: a new approach for human teratology. Cong Anom (Kyoto) 2008; 48: 103–109.

    Article  Google Scholar 

  82. Gönczi L, Czeizel A. Integrating smoking cessation into periconceptional care. Tobacco Control 1996; 5: 160.

    Article  PubMed  Google Scholar 

  83. Christian MS, Czeizel A. Introduction and history of the Hungarian project for monitoring suicide attempts in pregnant women. Toxic Indust Health 2008. 24: 5–9.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nándor Ács MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Ács, N., Bánhidy, F.G., Czeizel, A.E. (2010). The Hungarian Congenital Abnormality Registry (HCAR). In: Ács, N., Bánhidy, F., Czeizel, A. (eds) Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8620-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-90-481-8620-4_1

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-8619-8

  • Online ISBN: 978-90-481-8620-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics