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Abstract

Although the majority of patients do relatively well following gastric surgery, some develop severe malabsorption and present difficult problems of nutritional management. Partial gastric resection was the procedure most frequently performed for peptic ulcer disease up to a decade ago and is still performed today. These patients, particularly those with Billroth II gastric resection, present potentially serious malabsorption problems. Weight loss commonly occurs after gastrectomy, the incidence being variously reported between 30% and 84% (1–13). The most common cause of postgastrectomy weight loss, although it may be multifactorial, is not malabsorption but inadequate food intake, due to poor appetite early sensations or fear of postcibal symptoms [7, 12]. Weight changes are found mostly in the first year after operation, but thereafter small changes are observed. Johnston et al. [12] observed that those patients who had lost weight prior to subtotal gastrectomy tended to gain afterwards, but those who had maintained a steady weight or had had an increase in weight before the operation tended to lose afterwards (Fig. 57). After truncal vagotomy, Wastell [13] found that the method of drainage (pyloroplasty or gastro-enterostomy) did not influence the loss of weight, and about half or more of the patients lost weight after vagotomy and drainage. Wheldon et al. [5] found a weight more than 4 kg below standard in 47% of men and in 64% of women after truncal vagotomy with gastro-enterostomy.

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References

  1. Wall, A.J., Ungar, B., Baird, C.W., Langford, I.M., MacKay, I.R.: Malnutrition after partial gastrectomy. Am. J. Dig. Dis. 12, 1077 (1967)

    Article  PubMed  CAS  Google Scholar 

  2. Magnuson, F.K., Judd, E.S., Dearing, W.H.: Comparison of postgastrectomy complications in gastric and duodenal ulcer patients. Ann. Surg. 32, 375 (1966)

    CAS  Google Scholar 

  3. Cox, A.G.: The outcome of truncal vagotomy and a drainage procedure. Chapt. 5. In: Vagotomy on Trial, A.G. Cox, I.A. Williams, eds. Heinemann Medical Books 67 (1973)

    Google Scholar 

  4. Goligher, J.C., Pulvertaft, C.N., Watkinson, G.: Controlled trial of vagotomy and gastroenterostomy in elective treatment of duodenal ulcer: Interim report. Brit. med. J. I, 455 (1969)

    Google Scholar 

  5. Wheldon, E.J., Venables, C.W., Johnston, I.D.A.: Late metabolic sequelae of vagotomy and gastroenterostomy. Lancet I, 437 (1970)

    Article  Google Scholar 

  6. Williams, J.A.: Partial gastrectomy. The late nutritional and metabolic effects. Am. J. Proctol. 17, 288 (1966)

    PubMed  CAS  Google Scholar 

  7. Williams, J.A.: Postgastrectomy problems II. Brit. Med. J. 4, 467 (1967)

    Article  PubMed  CAS  Google Scholar 

  8. Mac Lean, L.D., Perry, J.F., Kelly, W.D., et al.: Nutrition following subtotal gastrectomy of four types (Billroth I and II, segmental and tubular resections). Surgery 35, 705 (1954)

    Google Scholar 

  9. Lundh, G.: Intestinal digestion and absorption after gastrectomy. Acta Chir. Scand. Suppl. 231, 1 (1958)

    Google Scholar 

  10. Hillman, H.S.: Postgastrectomy malnutrition. Gut 9, 576 (1968)

    Article  PubMed  CAS  Google Scholar 

  11. Pryor, J.P., O’Shea, M.J., Brooks, P.L., Datar, G.K.: The long-term metabolic consequences of partial gastrectomy. Am. J. Med. 51, 5 (1971)

    Article  PubMed  CAS  Google Scholar 

  12. Johnston, I.D.A.,Welbourne, R., Acheson, K.: Gastrectomy and loss of weight. Lancet 1, 1242 (1968)

    Google Scholar 

  13. Wastell, C.: Long-term clinical and metabolic effects of vagotomy with either gastrojejunostomy or pyloroplasty. Ann. Roy. Coll. Surg. Engl. 44, 193 (1969)

    Google Scholar 

  14. Jordan, P.H., Jr.: A prospective study of parietal cell vagotomy and selective vagotomy- antrectomy for treatment of duodenal ulcer. Ann. Surg. 183, 183 (1976)

    Article  Google Scholar 

  15. Welbourne, R.B.: Nutritional aspects of gastric surgery. Rev. Surg. 24, 233 (1967)

    Google Scholar 

  16. Butler, T.J.: A study of the pancreatic response to food after gastrectomy in man. Gut 1, 55 (1960)

    Article  PubMed  CAS  Google Scholar 

  17. Corsini, G., Gandolfi, E., Bonecki, I., Cerri, B.: Post-gastrectomy malabsorption. Gastroenterology 50, 358 (1966)

    PubMed  CAS  Google Scholar 

  18. MacKay, C.: Postgastrectomy steatorrhea. Am. J. Surg. 120, 324 (1970)

    PubMed  CAS  Google Scholar 

  19. Capper, W.M., Welbourne, R.B.: Early post-cibal symptoms following gastrectomy. Brit. J. Surg. 43, 24 (1955)

    Article  PubMed  CAS  Google Scholar 

  20. Orr, J.: Physiological considerations in the surgery of peptic ulcer. Ann. Roy. Coll. Surg. Engl. 34, 314 (1964)

    CAS  Google Scholar 

  21. Herrmann, G., Axtell, H.K., Starzl, T.E.: Fat absorption and the afferent loop. Surgery 57, 291 (1965)

    Google Scholar 

  22. Wollaeger, E.E., Waugh, J.M., Power, M.H.: Fat assimilation capacity of the GI tract after partial gastrectomy and gastroduodenostomy. Gastroenterology 44, 25 (1963)

    PubMed  CAS  Google Scholar 

  23. Shingleton, W.W., Isley, J.K., Floyd, R.D., et al.: Studies on postgastrectomy steatorrhea using radioactive triolein. Surgery 42, 12 (1957)

    PubMed  CAS  Google Scholar 

  24. Krikler, D.M., Schrire, V.: Kwashiorkor in an adult due to an intestinal blind loop. Lancet I, 510 (1958)

    Article  Google Scholar 

  25. Neale, G., Antcliff, A.C., Welbourne, R.B., et al.: Protein malnutrition after partial gastrectomy. Quarterl. J. Med. 36, 469 (1967)

    CAS  Google Scholar 

  26. Booth, C.C., Brain, M.C., Jeejeebhoy, K.N.: Late postgastrectomy syndromes. Hypoproteinemia after partial gastrectomy. Proc. Roy. Soc. Med. 57, 582 (1964)

    PubMed  CAS  Google Scholar 

  27. Brain, M.C., Unstall, H.B., Jeejeebhoy, K.N.: Postgastrectomy hypoproteinemia. Am. J. Med. 39, 674 (1965)

    Article  PubMed  CAS  Google Scholar 

  28. Buckler, K.G.: Effects of gastric surgery upon gastric emptying in cases of peptic ulceration. Gut 8, 484 (1965)

    Google Scholar 

  29. Wirts, L.W., Goldstein, F.: Studies on the mechanism of postgastrectomy steatorrhea. Ann. Internal Med. 58, 25 (1963)

    CAS  Google Scholar 

  30. Tabaqchali, S.: The pathophysiological role of small intestinal flora. Scand. J. Gastroenterol. (Suppl. 6 ) 5, 139 (1970)

    Google Scholar 

  31. Worning, H., Mulleritz, S., Hess Thaysen, E., et al.: pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with duodenal ulcer and in patients subjected to different operatons. Scand. J. Gastroenterol. 2, 23 (1967)

    Article  PubMed  CAS  Google Scholar 

  32. Glazebrook, A J., Welbourne, R.B.: Some observations on the function of the small intestine after gastrectomy. Br. J. Surg. 40, 111 (1952)

    Article  PubMed  CAS  Google Scholar 

  33. Annis, D., Hallenbeck, G.A.: The effects of partial gastrectomy on canine external pancreatic secretion. Surgery 31, 517 (1952)

    PubMed  CAS  Google Scholar 

  34. Malagelada, J.R., Go, V.L.W., Summerskill, W.J.H.: Altered pancreatic and biliary function after vagotomy and pyloroplasty. Gastroenterology 66, 22 (1974)

    PubMed  CAS  Google Scholar 

  35. MacGregor, I.L., Parent, J., Meyer, J.H.: Gastric emptying of liquid meals and pancreatic and biliary secretion after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. Gastroenterology 72, 195 (1977)

    PubMed  CAS  Google Scholar 

  36. Lagerlöf, H.O., Rudewald, M.B., Perman, G.: The neutralization process in duodenum and its influence on the gastric emptying in man. Acta med. Scand. 168, 269 (1960)

    Google Scholar 

  37. Fields, M., Duthie, H.L.: Effect of vagotomy on intraluminal digestion of fat in man. Gut 6, 301 (1965)

    Article  PubMed  CAS  Google Scholar 

  38. Toskes, P.P., Cerda, J.J.: The value of the gelatine infusion test in the diagnosis of pancreatic exocrine insufficiency in patients with Billroth II anastomosis. Am. J. Dig. Dis. 18, 147 (1973)

    Article  PubMed  CAS  Google Scholar 

  39. Scott, G.B., Williams, M.J., Clark, C.G.: Comparison of jejunal mucosa in postgastrectomy states, idiopathic steatorrhoea and controls using the dissecting microscope and conventional histologic methods. Gut 5, 553 (1964)

    Article  PubMed  CAS  Google Scholar 

  40. Rubin, C.E., Dobbins, W.O.: Peroral biopsy of the small intestine. A review of its diagnostic usefulness. Gastroenterology 49, 676 (1965)

    PubMed  CAS  Google Scholar 

  41. Hedberg, C.A., Melnyk, C.S., Johnson, C.F.: Gluten enteropathy appearing after gastric surgery. Gastroenterology 50, 796 (1966)

    PubMed  CAS  Google Scholar 

  42. Gryboski, J.D., Thayer, W.R., Gryboski, W.N., et al.: A defect in disaccharide metabolism after gastrojejunostomy. N. Engl. J. Med. 268, 78 (1963)

    Article  PubMed  CAS  Google Scholar 

  43. Bond, J.H., Levitt, M.D.: Use of breath hydrogen (H2) to quantitate small bowel transit time following partial gastrectomy. J. Lab. Clin. Med. 90, 30 (1977)

    PubMed  CAS  Google Scholar 

  44. Donaldson, R.M.: Small bowel bacterial overgrowth. Adv. Intern. Med. 16, 191 (1970)

    PubMed  Google Scholar 

  45. Ballinger, W.F., Lida, J., Padula, R.T., et al.: Bacterial inflammation and denervation atrophy of the small intestine. Surgery 57, 535 (1965)

    PubMed  Google Scholar 

  46. Bishop, R.F.: Bacterial flora of stomach and small intestine after gastric surgery. Ernährungsforschung 10, 417 (1965)

    Google Scholar 

  47. Greenlee, H.B., Gelbart, S.M., De Orio, A.J., et al.: The influence of gastric surgery on the intestinal flora. Am. J. Clin. Nutr. 30, 1826 (1977)

    PubMed  CAS  Google Scholar 

  48. Gorbach, S.L., Plant, A.G., Nahas, L., et al.: Studies of intestinal microflora I: Microorganisms of the small intestine and their relations to oral and rectal flora. Gastroenterology 53, 856 (1967)

    PubMed  CAS  Google Scholar 

  49. Draser, B.S., Shiner, M.: Studies on the intestinal flora. Part II: Bacterial flora of the small intestine in patients with gastrointestinal disorders. Gut 10, 812 (1969)

    Article  Google Scholar 

  50. Vantrappen, G., Janssens, J., Hellemans, J., et al.: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J. Clin. Invest. 59, 1158 (1977)

    Article  PubMed  CAS  Google Scholar 

  51. Browing, G.G., Buchan, K.A., Mackay, C.: The effect of vagotomy and drainage on the small bowel flora. Gut 15, 139 (1974)

    Article  Google Scholar 

  52. Paulley, J.W.: The jejunal mucosa in malabsorptive states with high bacterial counts. In: Girwood, R.H., Smith, A.N., eds. Malabsorption, p. 171. Edinburgh: University of Edinburgh Press 1969

    Google Scholar 

  53. Gracey, M., Burke, V., Oshin, A., et al.: Bacteria, bile salts and intestinal monosaccharide absorption. Gut 12, 683 (1971)

    Article  PubMed  CAS  Google Scholar 

  54. Gianella, R.A., Rout, W.R., Toskes, P.P.: Jejunal brush border injury and impaired sugar and amino acid uptake in the blind loop syndrome. Gastroenterology 67, 965 (1974)

    Google Scholar 

  55. Toskes, P.P., Gianella, R.A., Jervis, H.R., et al.: Small intestinal mucosal injury in the experimental blind loop syndrome: light- and electron-microscopic and histochemical studies. Gastroenterology 68, 1193 (1975)

    PubMed  CAS  Google Scholar 

  56. Ament, M.E., Shimoda, S.S., Saunders, D.R., et al.: Pathogenesis of steatorrhea in three cases of small intestinal stasis syndrome. Gastroenterology 63, 728 (1972)

    PubMed  CAS  Google Scholar 

  57. Donaldson, R.M.: Studies on the pathogenesis of steatorrhea in the blind loop syndrome. J. Clin. Invest. 44, 1815 (1965)

    Article  PubMed  Google Scholar 

  58. Kim, Y.S., Spritz, N., Blum, M., et al.: The role of altered bile acid metabolism in the steatorrhoea of experimental blind loop. J. Clin. Invest. 45, 956 (1966)

    Article  PubMed  CAS  Google Scholar 

  59. Fromm, H., Hofmann, A.F.: Breath test for altered bile acid metabolism. Lancet II, 621 (1971)

    Google Scholar 

  60. Caspary, W.F., Reimold, W.V.: Klinische Bedeutung des 14C-Glykocholat-Atemtestes in der gastroenterologischen Diagnostik bei Erkrankungen mit gesteigerter Dekonjugation von Gallensäuren. Dtsch. med. Wschr. 101, 353 (1976)

    CAS  Google Scholar 

  61. Caspary, W.F.: Breath tests. In: Clinics in Gastroenterology Vol. 7, 351 (1978)

    Google Scholar 

  62. Gianella,R.A., Broitman, S.A., Zamcheck, N.: Vitamin B12-uptake by intestinal microorganisms: mechanism and relevance to syndromes of intestinal bacterial overgrowth. J. Clin. Invest. 50, 110 (1971)

    Article  Google Scholar 

  63. Donaldson, R.M.: Malabsorption of Co60-labeled cyanocobalamin in rats with intestinal diverticula. I. Evaluation of possible mechanisms. Gastroenterology 43, 271 (1962)

    PubMed  CAS  Google Scholar 

  64. Schjonsky, H.: The absorption of vitamin B12 in the blind loop syndrome. Scand. J. Gastroenterology (Suppl.) 29, 65 (1974)

    Google Scholar 

  65. Goldstein, F., Karacadag, S., Wirts, C.W., et al.: Intraluminal small intestinal utilization of D-xylose by bacteria. Gastroenterology 59, 380 (1970)

    PubMed  CAS  Google Scholar 

  66. Spivey, J., Lorenz, E., Manderli, W., et al.: Evaluation of carbohydrate metabolism in patients with the blind loop syndrome. Gastroenterology 68, 1001 (1975)

    Google Scholar 

  67. Metz, G., Gassull, A.M., Drasar, B.S., et al.: Breath hydrogen test for small intestinal bacterial colonization. Lancet I, 668 (1976)

    Article  Google Scholar 

  68. King, C.E., Toskes, P.D.: Small intestine bacterial overgrowth. Gastroenterology 76, 1035 (1979)

    PubMed  CAS  Google Scholar 

  69. Campbell, C.B., Cowen, A.E., Harper, J.: Duodenal bacterial flora and bile salt patterns in patients with gastrointestinal disease. Austral. N.Z. J. Med. 3, 339 (1973)

    Article  CAS  Google Scholar 

  70. Gertner, J.M., Lilburn, M., Domnech: 25-hydroxycholecalciferol absorption in steatorrhea and postgastrectomy osteomalacia. Brit. Med. J. 1, 1310 (1977)

    Article  PubMed  CAS  Google Scholar 

  71. Schoen, M.S., Lindenbaum, J., Rogiusky, M.S., et al.: Significance of serum levels of 25-hydroxy-cholecalciferol in gastrointestinal disease. Am. J. Dig. Dis. 23, 137 (1978)

    Article  PubMed  CAS  Google Scholar 

  72. Engstrom, J., Hellstrom, K., Lundh, G., et al.: Microflora of small intestine, incidence of steatorrhea and indicanuria before and after conversion of Billroth II to Billroth I type of gastric resection. Acta chir. Scand. 139, 546 (1973)

    CAS  Google Scholar 

  73. Buchau, R., Clark, C.G., Downie, R.W.M.: Conversion to Billroth I anastomosis or enteroanastomosis for postgastrectomy states. Brit. J. Surg. 52, 651 (1965)

    Article  Google Scholar 

  74. Borg, I., Borgstrom, S.G., Haeger, K.: The value of the BII-BI conversion operation in the treatment of the postgastrectomy syndrome. Acta chir. Scand. 134, 655 (1968)

    CAS  Google Scholar 

  75. Rutledge, R.H.: Jejunal segments for the postgastrectomy syndromes. Ann. Surgery 169, 810 (1969)

    Article  CAS  Google Scholar 

  76. Wirts, C.W., Templeton, J.Y., Fineberg, C., et al.: The correction of postgastrectomy malabsorption following a jejunal interposition operation. Gastroenterology 49, 141 (1965)

    PubMed  CAS  Google Scholar 

  77. Henley, F.A.: Gastrectomy with replacement: a preliminary communication. Brit. J. Surg. 40, 118 (1952)

    Article  PubMed  CAS  Google Scholar 

  78. Hedenstedt, S., Lundqvist, G.: Antiperistaltic jejunal segment in gastric surgery. Acta chir. Scand. 133, 545 (1967)

    CAS  Google Scholar 

  79. Hedenstedt, S., Lundqvist, G.: Antrectomy plus jejunal transposition plus selective vagotomy. Acta chir. Scand. 134, 373 (1968)

    CAS  Google Scholar 

  80. Herrington, J.L.: Jejunal interposition for certain postgastrectomy syndromes. Surg. Clin. North Am. 46, 441 (1966)

    PubMed  Google Scholar 

  81. Kay, A.W., Cox, A.G.: Jejunal transposition for the postgastrectomy patient. Brit. J. Surg. 51, 763 (1964)

    Article  PubMed  CAS  Google Scholar 

  82. Herrington, J.L.: Remedial operations for severe postgastrectomy symptoms. Ann. Surg. 162, 789 (1965)

    Article  PubMed  CAS  Google Scholar 

  83. Herrington, J.L.: Utilization of small bowel segments as a gastric reservoir for control of the dumping syndrome. Am. J. Surg. 111, 89 (1969)

    Article  Google Scholar 

  84. Hedenstedt, S.: Gastrectomy with jejunal replacement. Acta Chir. Scand. 117, 295 (1959)

    CAS  Google Scholar 

  85. Fineberg, C., Templeton, J.Y. III, Wirts, C.W., et al.: The correction of postgastrectomy malabsorption by jejunal interposition. Surg. Clin. N. Amer. 53, 581 (1973)

    PubMed  CAS  Google Scholar 

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Becker, H.D., Caspary, W.F. (1980). Postgastrectomy Malabsorption. In: Postgastrectomy and Postvagotomy Syndromes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67350-4_18

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