Abstract
Nanooncology is based on the use of nanoscale materials to provide tools for cancer detection, prevention, diagnosis and treatment. Due to their unique physical and chemical properties, carbon nanotubes (CNTs) are among newly developed products and are currently of much interest, with a large amount of research dedicated to their novel applications. In cancer research, many advantages of CNTs in drug delivery systems, cellular Imaging, and Cancer Photothermal therapy draw attention. Their physicochemical features enable introduction of several pharmaceutically relevant entities and allow for rational design of novel candidate nanoscale constructs. Thus, a detailed understanding of recent progress in nanooncology, focusing on biomedical research exploring possible application of carbon nanotubes, is required to consider the medical applications of these materials.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adeli, M., Mirab, N., Zabihi, F.: Nanocapsules based on carbon nanotubes-graft-polyglycerol hybrid materials. Nanotechnology 20, 485–603 (2009). doi:10.1088/0957-4484/20/48/485603
Ajima, K., Murakami, T., Mizoguchi, Y., Tsuchida, K., Ichihashi, T., Iijima, S., Yudasaka, M.: Enhancement of in vivo anticancer effects of cisplatin by incorporation inside single-wall carbon nanohorns. ACS Nano 2, 2057–2064 (2008). doi:10.1021/nn800395t
Arlt, M., Haase, D., Hampel, S., Oswald, S., Bachmatiuk, A., Klingeler, R., Schulze, R., Ritschel, M., Leonhardt, A., Fuessel, S., Buchner, B., Kraemer, K., Wirth, M.P.: Delivery of carboplatin by carbon-based nanocontainers mediates increased cancer cell death. Nanotechnology 21, 335101 (2010). doi:10.1088/0957-4484/21/33/335101
Bai, X., Son, S.J., Zhang, S., Liu, W., Jordan, E.K., Frank, J.A., Venkatesan, T., Lee, S.B.: Synthesis of superparamagnetic nanotubes as MRI contrast agents and for cell labeling. Nanomedicine (Lond) 3, 163–174 (2008). doi:10.2217/17435889.3.2.163
Beg, S., Rizwan, M., Sheikh, A.M., Hasnain, M.S., Anwer, K., Kohli, K.: Advancement in carbon nanotubes: basics, biomedical applications and toxicity. J. Pharm. Pharmacol. 63, 141–163 (2011). doi:10.1111/j.2042-7158.2010.01167
Bhirde, A.A., Patel, V., Gavard, J., Zhang, G., Sousa, A.A., Masedunskas, A., Leapman, R.D., Weigert, R., Gutkind, J.S., Rusling, J.F.: Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 3, 307–316 (2009). doi:10.1021/nn800551s
Bianco, A., Kostarelos, K., Prato, M.: Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol. 9, 674–679 (2005). doi:10.1016/j.cbpa.2005.10.005
Boczkowski, J., Lanone, S.: Potential uses of carbon nanotubes in the medical field: how worried should patients be? Nanomedicine (Lond) 2, 407–410 (2007). doi:10.2217/17435889.2.4.407
Burke, A., Ding, X., Singh, R., Kraft, R.A., Levi-Polyachenko, N., Rylander, M.N., Szot, C., Buchanan, C., Whitney, J., Fisher, J., Hatcher, H.C., D’Agostino Jr, R., Kock, N.D., Ajayan, P.M., Carroll, D.L., Akman, S., Torti, F.M., Torti, S.V.: Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc. Natl. Acad. Sci. U S A 106, 12897–12902 (2009). doi:10.1073/pnas.0905195106
Burke, A.R., Singh, R.N., Carroll, D.L., Owen, J.D., Kock, N.D., D’Agostino Jr, R., Torti, F.M., Torti, S.V.: Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Biomaterials 32, 5970–5978 (2011). doi:10.1016/j.biomaterials.2011.04.059
Cai, D., Mataraza, J.M., Qin, Z.H., Huang, Z., Huang, J., Chiles, T.C., Carnahan, D., Kempa, K., Ren, Z.: Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nat. Methods 2, 449–454 (2005). doi:10.1038/nmeth761
Chakravarty, P., Marches, R., Zimmerman, N.S., Swafford, A.D., Bajaj, P., Musselman, I.H., Pantano, P., Draper, R.K., Vitetta, E.S.: Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes. Proc. Natl. Acad. Sci. U S A 105, 8697–8702 (2008). doi:10.1073/pnas.0803557105
Cherukuri, P., Gannon, C.J., Leeuw, T.K., Schmidt, H.K., Smalley, R.E., Curley, S.A., Weisman, R.B.: Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc. Natl. Acad. Sci. U S A 103, 18882–18886 (2006). doi:10.1073/pnas.0609265103
Cheung, W., Pontoriero, F., Taratula, O., Chen, A.M., He, H.: DNA and carbon nanotubes as medicine. Adv. Drug Deliv. Rev. 62, 633–649 (2010). doi:10.1016/j.addr.2010.03.007
De la Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B.R., Ma, T.J., Oralkan, O., Cheng, Z., Chen, X., Dai, H., Khuri-Yakub, B.T., Gambhir, S.S.: Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat. Nanotechnol. 3, 557–562 (2008). doi:10.1038/nnano.2008.231
Dhar, S., Liu, Z., Thomale, J., Dai, H., Lippard, S.J.: Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J. Am. Chem. Soc. 130, 11467–11476 (2008). doi:10.1021/ja803036e
Di Crescenzo, A., Velluto, D., Hubbell, J.A., Fontana, A.: Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs. Nanoscale 3, 925–928 (2011). doi:10.1039/c0nr00444h
Dumortier, H., Lacotte, S., Pastorin, G., Marega, R., Wu, W., Bonifazi, D., Briand, J.P., Prato, M., Muller, S., Bianco, A.: Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano. Lett. 6, 1522–1528 (2006). doi:10.1021/nl061160x
Firme III, C.P., Bandaru, P.R.: Toxicity issues in the application of carbon nanotubes to biological systems. Nanomedicine 6, 245–256 (2010). doi:10.1016/j.nano.2009.07.003
Foldvari, M., Bagonluri, M.: Carbon nanotubes as functional excipients for nanomedicines: II drug delivery and biocompatibility issues. Nanomedicine 4, 183–200 (2008). doi:10.1016/j.nano.2008.04.003
Georgakilas, V., Kordatos, K., Prato, M., Guldi, D.M., Holzinger, M., Hirsch, A.: Organic functionalization of carbon nanotubes. J. Am. Chem. Soc. 124, 760–761 (2002). doi:10.1021/ja016954m
Hampel, S., Kunze, D., Haase, D., Kramer, K., Rauschenbach, M., Ritschel, M., Leonhardt, A., Thomas, J., Oswald, S., Hoffmann, V., Buchner, B.: Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growth. Nanomedicine (Lond) 3, 175–182 (2008). doi:10.2217/17435889.3.2.175
Heister, E., Lamprecht, C., Neves, V., Tilmaciu, C., Datas, L., Flahaut, E., Soula, B., Hinterdorfer, P., Coley, H.M., Silva, S.R., McFadden, J.: Higher dispersion efficacy of functionalized carbon nanotubes in chemical and biological environments. ACS Nano 4, 2615–2626 (2010). doi:10.1021/nn100069k
Hilder, T.A., Hill, J.M.: Modeling the loading and unloading of drugs into nanotubes. Small 5, 300–308 (2009). doi:10.1002/smll.200800321
Huang, H., Yuan, Q., Shah, J.S., Misra, R.D.: A new family of folate-decorated and carbon nanotube-mediated drug delivery system: synthesis and drug delivery response. Adv. Drug Deliv. Rev. (2011). doi:10.1016/j.addr.2011.04.001
Huang, H.C., Barua, S., Sharma, G., Dey, S.K., Rege, K.: Inorganic nanoparticles for cancer imaging and therapy. J Control Release (2011). doi:10.1016/j.jconrel.2011.07.005
Iancu, C., Mocan, L., Bele, C., Orza, A.I., Tabaran, F.A., Catoi, C., Stiufiuc, R., Stir, A., Matea, C., Iancu, D., Agoston-Coldea, L., Zaharie, F., Mocan, T.: Enhanced laser thermal ablation for the in vitro treatment of liver cancer by specific delivery of multiwalled carbon nanotubes functionalized with human serum albumin. Int. J. Nanomedicine 6, 129–141 (2011). doi:10.2147/IJN.S15841
Jain, K.K.: Advances in the field of nanooncology. BMC Med. 8, 83 (2010). doi:10.1186/1741-7015-8-83
Ji, S.R., Liu, C., Zhang, B., Yang, F., Xu, J., Long, J., Jin, C., Fu, D.L., Ni, Q.X., Yu, X.J.: Carbon nanotubes in cancer diagnosis and therapy. Biochim. Biophys. Acta 1806, 29–35 (2010). doi:10.1016/j.bbcan.2010.02.004
Kam, N.W., Liu, Z., Dai, H.: Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew. Chem. Int. Ed. Engl. 45, 577–581 (2006). doi:10.1002/anie.200503389
Kam, N.W., O’Connell, M., Wisdom, J.A., Dai, H.: Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl. Acad. Sci. U S A 102, 11600–11605 (2005). doi:10.1073/pnas.0502680102
Karmakar, A., Bratton, S.M., Dervishi, E., Ghosh, A., Mahmood, M., Xu, Y., Saeed, L.M., Mustafa, T., Casciano, D., Radominska-Pandya, A., Biris, A.S.: Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells. Int J Nanomedicine 6, 1045–1055 (2011). doi:10.2147/IJN.S17684
Kostarelos, K., Bianco, A., Prato, M.: Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat. Nanotechnol. 4, 627–633 (2009). doi:10.1038/nnano.2009.241
Kostarelos, K., Lacerda, L., Pastorin, G., Wu, W., Wieckowski, S., Luangsivilay, J., Godefroy, S., Pantarotto, D., Briand, J.P., Muller, S., Prato, M., Bianco, A.: Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat. Nanotechnol. 2, 108–113 (2007). doi:10.1038/nnano.2006.209
Lay, C.L., Liu, H.Q., Tan, H.R., Liu, Y.: Delivery of paclitaxel by physically loading onto poly(ethylene glycol) (PEG)-graft-carbon nanotubes for potent cancer therapeutics. Nanotechnology 21, 065101 (2010). doi:10.1088/0957-4484/21/6/065101
Li, R., Wu, R., Zhao, L., Wu, M., Yang, L., Zou, H.: P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells. ACS Nano 4, 1399–1408 (2010). doi:10.1021/nn9011225
Liang, F., Chen, B.: A review on biomedical applications of single-walled carbon nanotubes. Curr. Med. Chem. 17, 10–24 (2010)
Liu, X., Tao, H., Yang, K., Zhang, S., Lee, S.T., Liu, Z.: Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors. Biomaterials 32, 144–151 (2011). doi:10.1016/j.biomaterials.2010.08.096
Liu, Z., Cai, W., He, L., Nakayama, N., Chen, K., Sun, X., Chen, X., Dai, H.: In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol. 2, 47–52 (2007). doi:10.1038/nnano.2006.170
Liu, Z., Chen, K., Davis, C., Sherlock, S., Cao, Q., Chen, X., Dai, H.: Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res. 68, 6652–6660 (2008). doi:10.1158/0008-5472.CAN-08-1468
Liu, Z., Davis, C., Cai, W., He, L., Chen, X., Dai, H.: Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc. Natl. Acad. Sci. U S A 105, 1410–1415 (2008). doi:10.1073/pnas.0707654105
Liu, Z., Li, X., Tabakman, S.M., Jiang, K., Fan, S., Dai, H.: Multiplexed multicolor Raman imaging of live cells with isotopically modified single walled carbon nanotubes. J. Am. Chem. Soc. 130, 13540–13541 (2008). doi:10.1021/ja806242t
Liu, Z., Sun, X., Nakayama-Ratchford, N., Dai, H.: Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano 1, 50–56 (2007). doi:10.1021/nn700040t
Liu, Z., Tabakman, S., Welsher, K., Dai, H.: Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2, 85–120 (2009). doi:10.1007/s12274-009-9009-8
Luo, J., Solimini, N.L., Elledge, S.J.: Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136, 823–837 (2009). doi:10.1016/j.cell.2009.02.024
Maeda, H., Bharate, G.Y., Daruwalla, J.: Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur. J. Pharm. Biopharm. 71, 409–419 (2009). doi:10.1016/j.ejpb.2008.11.010
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K.: Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65, 271–284 (2000). doi:S0168-3659(99)00248-5
Marches, R., Mikoryak, C., Wang, R.H., Pantano, P., Draper, R.K., Vitetta, E.S.: The importance of cellular internalization of antibody-targeted carbon nanotubes in the photothermal ablation of breast cancer cells. Nanotechnology 22, 095101 (2011). doi:10.1088/0957-4484/22/9/095101
Matsumura, S., Ajima, K., Yudasaka, M., Iijima, S., Shiba, K.: Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol. Mol. Pharm. 4, 723–729 (2007). doi:10.1021/mp070022t
McDevitt, M.R., Chattopadhyay, D., Kappel, B.J., Jaggi, J.S., Schiffman, S.R., Antczak, C., Njardarson, J.T., Brentjens, R., Scheinberg, D.A.: Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J. Nucl. Med. 48, 1180–1189 (2007). doi:10.2967/jnumed.106.039131
Misra, R., Acharya, S., Sahoo, S.K.: Cancer nanotechnology: application of nanotechnology in cancer therapy. Drug Discov Today 15, 842–850 (2010). doi:10.1016/j.drudis.2010.08.006
Miyawaki, J., Yudasaka, M., Azami, T., Kubo, Y., Iijima, S.: Toxicity of single-walled carbon nanohorns. ACS Nano 2, 213–226 (2008). doi:10.1021/nn700185t
Mocan, L., Tabaran, F.A., Mocan, T., Bele, C., Orza, A.I., Lucan, C., Stiufiuc, R., Manaila, I., Iulia, F., Dana, I., Zaharie, F., Osian, G., Vlad, L., Iancu, C.: Selective ex vivo photothermal ablation of human pancreatic cancer with albumin functionalized multiwalled carbon nanotubes. Int J Nanomedicine 6, 915–928 (2011). doi:10.2147/IJN.S19013
Murakami, T., Ajima, K., Miyawaki, J., Yudasaka, M., Iijima, S., Shiba, K.: Drug-loaded carbon nanohorns: adsorption and release of dexamethasone in vitro. Mol. Pharm. 1, 399–405 (2004). doi:10.1021/mp049928e
Murugesan, S., Park, T.J., Yang, H., Mousa, S., Linhardt, R.J.: Blood compatible carbon nanotubes–nano-based neoproteoglycans. Langmuir 22, 3461–3463 (2006). doi:10.1021/la0534468
Nimmagadda, A., Thurston, K., Nollert, M.U., McFetridge, P.S.: Chemical modification of SWNT alters in vitro cell-SWNT interactions. J. Biomed. Mater. Res. A 76, 614–625 (2006). doi:10.1002/jbm.a.30577
Pacurari, M., Qian, Y., Porter, D.W., Wolfarth, M., Wan, Y., Luo, D., Ding, M., Castranova, V., Guo, N.L.: Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology. Toxicol. Appl. Pharmacol. 255, 18–31 (2011). doi:10.1016/j.taap.2011.05.012
Pantarotto, D., Partidos, C.D., Hoebeke, J., Brown, F., Kramer, E., Briand, J.P., Muller, S., Prato, M., Bianco, A.: Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. 10, 961–966 (2003). doi:S107455210300214X
Park, Y.K., Bold, B., Lee, W.K., Jeon, M.H., An, K.H., Jeong, S.Y., Shim, Y.K.: d-(+)-Galactose-conjugated single-walled carbon nanotubes as new chemical probes for electrochemical biosensors for the cancer marker galectin-3. Int. J. Mol. Sci. 12, 2946–2957 (2011). doi:10.3390/ijms12052946
Pastorin, G., Wu, W., Wieckowski, S., Briand, J.P., Kostarelos, K., Prato, M., Bianco, A.: Double functionalization of carbon nanotubes for multimodal drug delivery. Chem. Commun. (Camb) 1182–1184 (2006). doi: 10.1039/b516309a
Prakash, S., Malhotra, M., Shao, W., Tomaro-Duchesneau, C., Abbasi, S.: Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy. Adv. Drug Deliv. Rev. (2011). doi:10.1016/j.addr.2011.06.013
Pramanik, M., Swierczewska, M., Green, D., Sitharaman, B., Wang, L.V.: Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent. J. Biomed. Opt. 14, 034018 (2009). doi:10.1117/1.3147407
Prato, M., Kostarelos, K., Bianco, A.: Functionalized carbon nanotubes in drug design and discovery. Acc. Chem. Res. 41, 60–68 (2008). doi:10.1021/ar700089b
Pulskamp, K., Diabate, S., Krug, H.F.: Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol. Lett. 168, 58–74 (2007). doi:10.1016/j.toxlet.2006.11.001
Raffa, V., Ciofani, G., Vittorio, O., Riggio, C., Cuschieri, A.: Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine (Lond.) 5, 89–97 (2010). doi:10.2217/nnm.09.95
Ruggiero, A., Villa, C.H., Holland, J.P., Sprinkle, S.R., May, C., Lewis, J.S., Scheinberg, D.A., McDevitt, M.R.: Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes. Int. J. Nanomedicine 5, 783–802 (2010). doi:10.2147/IJN.S13300
Sahoo, N.G., Bao, H., Pan, Y., Pal, M., Kakran, M., Cheng, H.K., Li, L., Tan, L.P.: Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study. Chem. Commun. (Camb.) 47, 5235–5237 (2011). doi:10.1039/c1cc00075f
Shvedova, A.A., Kisin, E.R., Porter, D., Schulte, P., Kagan, V.E., Fadeel, B., Castranova, V.: Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: two faces of Janus? Pharmacol. Ther. 121, 192–204 (2009). doi:10.1016/j.pharmthera.2008.10.009
Singh, R., Pantarotto, D., Lacerda, L., Pastorin, G., Klumpp, C., Prato, M., Bianco, A., Kostarelos, K.: Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl. Acad. Sci. U S A 103, 3357–3362 (2006). doi:10.1073/pnas.0509009103
Singh, R., Pantarotto, D., McCarthy, D., Chaloin, O., Hoebeke, J., Partidos, C.D., Briand, J.P., Prato, M., Bianco, A., Kostarelos, K.: Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J. Am. Chem. Soc. 127, 4388–4396 (2005). doi:10.1021/ja0441561
Sobhani, Z., Dinarvand, R., Atyabi, F., Ghahremani, M., Adeli, M.: Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube. Int. J. Nanomedicine 6, 705–719 (2011). doi:10.2147/IJN.S17336
Tasis, D., Tagmatarchis, N., Bianco, A., Prato, M.: Chemistry of carbon nanotubes. Chem. Rev. 106, 1105–1136 (2006). doi:10.1021/cr050569o
Tasis, D., Tagmatarchis, N., Georgakilas, V., Prato, M.: Soluble carbon nanotubes. Chemistry 9, 4000–4008 (2003). doi:10.1002/chem.200304800
Thomas, L.V., Arun, U., Remya, S., Nair, P.D.: A biodegradable and biocompatible PVA-citric acid polyester with potential applications as matrix for vascular tissue engineering. J. Mater. Sci. Mater. Med. 20(Suppl 1), S259–S269 (2009). doi:10.1007/s10856-008-3599-7
Valcarcel, M., Cardenas, S., Simonet, B.M.: Role of carbon nanotubes in analytical science. Anal. Chem. 79, 4788–4797 (2007). doi:10.1021/ac070196m
Venturelli, E., Fabbro, C., Chaloin, O., Menard-Moyon, C., Smulski, C.R., Da, R.T., Kostarelos, K., Prato, M., Bianco, A.: Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding. Small 7, 2179–2187 (2011). doi:10.1002/smll.201100137
Villa, C.H., Dao, T., Ahearn, I., Fehrenbacher, N., Casey, E., Rey, D.A., Korontsvit, T., Zakhaleva, V., Batt, C.A., Philips, M.R., Scheinberg, D.A.: Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. ACS Nano 5, 5300–5311 (2011). doi:10.1021/nn200182x
Vittorio, O., Raffa, V., Cuschieri, A.: Influence of purity and surface oxidation on cytotoxicity of multiwalled carbon nanotubes with human neuroblastoma cells. Nanomedicine 5, 424–431 (2009). doi:10.1016/j.nano.2009.02.006
Wang, J., Liu, G., Jan, M.R.: Ultrasensitive electrical biosensing of proteins and DNA: carbon-nanotube derived amplification of the recognition and transduction events. J. Am. Chem. Soc. 126, 3010–3011 (2004). doi:10.1021/ja031723w
Wang, L., Luanpitpong, S., Castranova, V., Tse, W., Lu, Y., Pongrakhananon, V., Rojanasakul, Y.: Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. Nano Lett. 11, 2796–2803 (2011). doi:10.1021/nl2011214
Wang, X., Jia, G., Wang, H., Nie, H., Yan, L., Deng, X.Y., Wang, S.: Diameter effects on cytotoxicity of multi-walled carbon nanotubes. J. Nanosci. Nanotechnol. 9, 3025–3033 (2009)
Warheit, D.B., Laurence, B.R., Reed, K.L., Roach, D.H., Reynolds, G.A., Webb, T.R.: Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 77, 117–125 (2004). doi:10.1093/toxsci/kfg228
Welsher, K., Liu, Z., Daranciang, D., Dai, H.: Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. Nano Lett. 8, 586–590 (2008). doi:10.1021/nl072949q
Whitney, J.R., Sarkar, S., Zhang, J., Do, T., Young, T., Manson, M.K., Campbell, T.A., Puretzky, A.A., Rouleau, C.M., More, K.L., Geohegan, D.B., Rylander, C.G., Dorn, H.C., Rylander, M.N.: Single walled carbon nanohorns as photothermal cancer agents. Lasers Surg. Med. 43, 43–51 (2011). doi:10.1002/lsm.21025
Worle-Knirsch, J.M., Pulskamp, K., Krug, H.F.: Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett. 6, 1261–1268 (2006). doi:10.1021/nl060177c
Wu, H., Liu, G., Wang, X., Zhang, J., Chen, Y., Shi, J., Yang, H., Hu, H., Yang, S.: Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery. Acta Biomater. 7, 3496–3504 (2011). doi:10.1016/j.actbio.2011.05.031
Wu, W., Li, R., Bian, X., Zhu, Z., Ding, D., Li, X., Jia, Z., Jiang, X., Hu, Y.: Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS Nano 3, 2740–2750 (2009). doi:10.1021/nn9005686
Wu, Y., Phillips, J.A., Liu, H., Yang, R., Tan, W.: Carbon nanotubes protect DNA strands during cellular delivery. ACS Nano 2, 2023–2028 (2008). doi:10.1021/nn800325a
Yang, F., Hu, J., Yang, D., Long, J., Luo, G., Jin, C., Yu, X., Xu, J., Wang, C., Ni, Q., Fu, D.: Pilot study of targeting magnetic carbon nanotubes to lymph nodes. Nanomedicine (Lond.) 4, 317–330 (2009). doi:10.2217/nnm.09.5
Yang, F., Jin, C., Yang, D., Jiang, Y., Li, J., Di, Y., Hu, J., Wang, C., Ni, Q., Fu, D.: Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment. Eur. J. Cancer 47, 1873–1882 (2011). doi:10.1016/j.ejca.2011.03.018
Zhang, H., Jiang, H., Sun, F., Wang, H., Zhao, J., Chen, B., Wangb, X.: Rapid diagnosis of multidrug resistance in cancer by electrochemical sensor based on carbon nanotubes–drug supramolecular nanocomposites. Biosens. Bioelectron. 26, 3361–3366 (2011). doi:10.1016/j.bios.2011.01.020
Zhang, X., Meng, L., Lu, Q., Fei, Z., Dyson, P.J.: Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 30, 6041–6047 (2009). doi:10.1016/j.biomaterials.2009.07.025
Zhang, Y., Bai, Y., Yan, B.: Functionalized carbon nanotubes for potential medicinal applications. Drug Discov. Today 15, 428–435 (2010). doi:10.1016/j.drudis.2010.04.005
Zhou, F., Xing, D., Ou, Z., Wu, B., Resasco, D.E., Chen, W.R.: Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes. J. Biomed. Opt. 14, 021009 (2009). doi:10.1117/1.3078803
Zhou, F., Xing, D., Wu, B., Wu, S., Ou, Z., Chen, W.R.: New insights of transmembranal mechanism and subcellular localization of noncovalently modified single-walled carbon nanotubes. Nano Lett. 10, 1677–1681 (2010). doi:10.1021/nl100004m
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Yurgel, V.C., Campos, V.F., Collares, T., Seixas, F. (2013). Applications of Carbon Nanotubes in Oncology. In: Avellaneda, C. (eds) NanoCarbon 2011. Carbon Nanostructures, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31960-0_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-31960-0_5
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31959-4
Online ISBN: 978-3-642-31960-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)