Abstract
In the present review we will concentrate on the “new view” (which emerged in the last years) onto ion—related and electrical processes in biological cells. In the second part we will look onto the consequences of these properties for interfacing with technical devices.
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References
Adams, D.S., Masi, A., Levin, M.: \({\rm H}^{+}\) pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development 134, 1323–1335 (2007)
Adams, D.S., Robinson, K.R., Fukumoto, T., Yuan, S., Albertson, R.C., Yelick, P., Kuo, L., McSweeney, M., Levin, M.: Early, \({\rm H}^{+}\)-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development 133, 1657–1671 (2006)
Adey, W.R.: Collective properties of cell membranes. In: B. Norden, K. Ramel (eds.) Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems. Oxford University Press, Oxford (1992)
Adey, W.R.: Elf magnetic fields and promotion of cancer; experimental studies. In: B. Norden, K. Ramel (eds.) Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems. Oxford University Press, Oxford (1992)
Adey, W.R.: Evidence for nonthermal electromagnetic bioeffects: potential health risks in evolving low-frequency and microwave environments. In: Clements-Croome, D. (ed.) Electromagnetic Environments and Safety in Buildings. Taylor and Francis, Spon Press, London (2003)
Astumian, R.D.: Electroconformational coupling of membrane proteins. Annals N. Y. Acad. Sci. 720, 136–140 (1994)
Astumian, R.D.: Thermodynamics and kinetics of a brownian motor. Science 276, 917–922 (1997)
Aswal, D.K., Lenfant, S., Guerin, D., Yakhmi, J.V., Vuillaume, D.: Self assembled monolayers on silicon for molecular electronics. Anal. Chim. Acta 568, 84–108 (2006)
Badzey, R.L., Mohanty, P.: Coherent signal amplification in bistable nanomechanical oscillators by stochastic resonance. Nature 437, 995–998 (2005)
Blank, M.: Do electromagnetic fields interact with electrons in the Na, K-ATPase? Bioelectromagnetics 26, 677–683 (2005)
Blank, M., Soo, L.: Enhancement of cytochrome oxidase activity in 60 Hz magnetic fields. Bioelectrochem. Bioenerg. 45, 253–259 (1998)
Blank, M., Soo, L.: Frequency dependency of cytochrome oxidase activity in magnetic fields. Bioelectrochem. Bioenerg. 46, 139–143 (1998)
Blank, M., Soo, L.: Optimal frequencies for magnetic acceleration of cytochrome oxidase and NaK-ATPase reactions. Bioelectrochemistry 53, 171–174 (2001)
Blank, M., Soo, L.: Electromagnetic acceleration of the Belousov-Zhabotinski reaction. Bioelectrochemistry 61, 93–97 (2003)
Borgens, R., et al.: Electric Fields in Vertebrate Repair. Wiley, NewYork (1989)
Braun, D., Fromherz, P.: Imaging neuronal seal resistance on silicon chip using fluorescent voltage-sensitive dye. Biophys. J. 87, 1351–1359 (2004)
Breme, J., Kirkpatrick, C.J., Thull, R.: Metallic Biomaterial Interfaces. Wiley-Vch, Weinheim (2007). ISBN: 978-3527318605
Brown, M.J., Loew, L.M.: Electric field-directed fibroblast locomotion involves cell surface molecular reorganization and is calcium independent. J. Cell Biol. 127, 117–128 (1994)
Buck, S.M., Xu, H., Brasuel, M., Philbert, M.A., Kopelman, R.: Nanoscale probes encapsulated by biologically localized embedding (PEBBLEs) for ion sensing and imaging in live cells. Talanta 63, 41–59 (2004)
Chang, W.H., Chang, K.T., Li, J.: Applications of therapeutic effects of electromagnetic fields. In: Stavroulakis, P. (ed.) Biological Effects of Electromagnetic Fields: Mechanisms, Modeling, Biological Effects, Therapeutic Effects, International Standards. Exposure Criteria. Springer, Berlin (2003). ISBN 978-3540429890
Cho, M.R., Thatte, H.S., Lee, R.C., Golan, D.E.: Reorganization of microfilament structure induced by ac electric fields. FASEB J. 10, 1552–1558 (1996)
Cooper, M.S., Keller, R.E.: Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields. Proc. Natl. Acad. Sci. USA 81, 160–164 (1984)
Denker, S.P., Huang, D.C., Orlowski, J., Furthmayr, H., Barber, D.L.: Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol. Cell. 6, 1425–1436 (2000)
Eddleman, C.S., Bittner, G.D., Fishman, H.M.: Barrier permeability at cut axonal ends progressively decreases until an ionic seal is formed. Biophys. J. 79, 1883–1890 (2000)
Fecko, C.J., Eaves, J.D., Loparo, J.J., Tokmakoff, A., Geissler, P.L.: Ultrafast hydrogen-bond dynamics in the infrared spectroscopy of water. Science 301, 1698–1702 (2003)
Fields, R.D.: The shark’s electric sense. Sci. Am. 297, 74–80 (2007)
Fishman, H.M., Bittner, G.D.: Vesicle-mediated restoration of a plasmalemmal barrier in severed axons. News Physiol. Sci. 18, 115–118 (2003)
Fitzsimmons, R.J., Baylink, D.J.: Growth factors and electromagnetic fields in bone. Clin. Plast. Surg. 21, 401–406 (1994)
Fitzsimmons, R.J., Strong, D.D., Mohan, S., Baylink, D.J.: Low-amplitude, low-frequency electric field-stimulated bone cell proliferation may in part be mediated by increased IGF-II release. J. Cell. Physiol. 150, 84–89 (1992)
Friedl, P., Wolf, K.: Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3, 362–374 (2003)
Funk, R.H., Monsees, T., Ozkucur, N.: Electromagnetic effects—from cell biology to medicine. Prog. Histochem. Cytochem. 43, 177–264 (2009)
Funk, R.H., Monsees, T.K.: Effects of electromagnetic fields on cells: physiological and therapeutical approaches and molecular mechanisms of interaction. A review. Cells Tissues Organs 182, 59–78 (2006)
Funk, R.H.W., Apple, D.J., Naumann, G.O.H.: Embryologie, anatomie und untersuchungstechnik. In: Naumann, G.O.H. (ed.) Pathologie des Auges. Springer, Berlin (2002)
Gartzke, J., Lange, K.: Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli. Am. J. Physiol. Cell Physiol. 283, C1333–C1346 (2002)
Grasso, S., Hernandez, J.A., Chifflet, S.: Roles of wound geometry, wound size, and extracellular matrix in the healing response of bovine corneal endothelial cells in culture. Am. J. Physiol. Cell Physiol. 293, C1327–C1337 (2007)
Grinstein, S., Woodside, M., Waddell, T.K., Downey, G.P., Orlowski, J., Pouyssegur, J., Wong, D.C., Foskett, J.K.: Focal localization of the NHE-1 isoform of the \({\rm Na}^{+}\)/\({\rm H}^{+}\) antiport: assessment of effects on intracellular pH. Embo J. 12, 5209–5218 (1993)
Harris, A.K., Pryer, N.K., Paydarfar, D.: Effects of electric fields on fibroblast contractility and cytoskeleton. J. Exp. Zool. 253, 163–176 (1990)
Hastings, G.W., Mahmud, F.A.: Electrical effects in bone. J. Biomed. Eng. 10, 515–521 (1988)
Hotary, K.B., Robinson, K.R.: Endogenous electrical currents and the resultant voltage gradients in the chick embryo. Dev. Biol. 140, 149–160 (1990)
Hotary, K.B., Robinson, K.R.: Evidence of a role for endogenous electrical fields in chick embryo development. Development 114, 985–996 (1992)
Jaffe, L.: Developmental currents, voltages, and gradients. In: S. Subtelny (ed.) Developmental Order: its origin and regulation, pp. 183–215. Alan R Liss, NewYork (1982)
Kindzelskii, A.L., Petty, H.R.: Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses. Eur. Biophys. J. 35, 1–26 (2005)
Klein, M., Seeger, P., Schuricht, B., Alper, S.L., Schwab, A.: Polarization of \({{\rm Na}^{+}}/{{\rm H}^{+}}\) and \({{\rm Cl}^{-}}/{{\rm HCO}^{-}_3}\) exchangers in migrating renal epithelial cells. J. Gen. Physiol. 115, 599–608 (2000)
Konig, S., Beguet, A., Bader, C.R., Bernheim, L.: The calcineurin pathway links hyperpolarization (Kir2.1)-induced \({\rm Ca}^{2+}\) signals to human myoblast differentiation and fusion. Development 133, 3107–3114 (2006)
Kruglikov, I.L., Dertinger, H.: Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells. Bioelectromagnetics 14, 539–547 (1994)
Kushmerick, J.G., Blum, A.S., Long, D.P.: Metrology for molecular electronics. Anal. Chim. Acta 568, 20–27 (2006)
Lauffenburger, D.A., Horwitz, A.F.: Cell migration: a physically integrated molecular process. Cell 84, 359–369 (1996)
Lee, H., Cheng, Y.C., Fleming, G.R.: Coherence dynamics in photosynthesis: protein protection of excitonic coherence. Science 316, 1462–1465 (2007)
Levin, M.: Large-scale biophysics: ion flows and regeneration. Trends Cell Biol. 17, 261–270 (2007)
Levin, M., Thorlin, T., Robinson, K.R., Nogi, T., Mercola, M.: Asymmetries in \({{\rm H}^{+}}/{{\rm K}^{+}}\)-ATPase and cell membrane potentials comprise a very early step in left-right patterning. Cell 111, 77–89 (2002)
Liboff, R.L.: Ion cyclotron resonance in biological systems: Experimental evidence. In: Stavroulakis, P. (ed.) Biological Effects of Electromagnetic Fields: mechanisms, modeling, biological effects, therapeutic effects, international standards. Exposure Criteria. Springer, Berlin (2003)
Marsh, G., Beams, H.W.: Electrical control of morphogenesis in regenerating dugesia tigrina. I. relation of axial polarity to field strength. J. Cell. Physiol. 39, 191–213 (1952)
Mathias, R.T., Rae, J.L., Baldo, G.J.: Physiological properties of the normal lens. Physiol. Rev. 77, 21–50 (1997)
McCaig, C.D., Rajnicek, A.M., Song, B., Zhao, M.: Controlling cell behavior electrically: current views and future potential. Physiol. Rev. 85, 943–978 (2005)
McCaig, C.D., Zhao, M.: Physiological electrical fields modify cell behaviour. Bioessays 19, 819–826 (1997)
McLeod, K.J., Rubin, C.T., Donahue, H.J.: Electromagnetic fields in bone repair and adaption. Radio Sci. 30, 233–244 (1995)
Metcalf, M.E.M., Shi, R., Borgens, R.B.: Endogenous ionic currents and voltages in amphibian embryos. J. Exp. Zool. 268, 307–322 (1994)
Mifsud, N., Scott, I., Green, A., Tattersall, J.: Temperature effects in brain slices exposed to radiofrequency fields. In: Presentation during the ERG101.013 (EDA) meeting at Dutch Ministry of Deference. The Hague, 21–22 Nov 2006
Monsees, T.K., Barth, K., Tippelt, S., Heidel, K., Gorbunov, A., Pompe, W., Funk, R.H.: Effects of different titanium alloys and nanosize surface patterning on adhesion, differentiation, and orientation of osteoblast-like cells. Cells Tissues Organs 180, 81–95 (2005)
Mycielska, M.E., Djamgoz, M.B.: Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease. J. Cell Sci. 117, 1631–1639 (2004)
Nishimura, K.Y., Isseroff, R.R., Nuccitelli, R.: Human keratinocytes migrate to the negative pole in direct current electric fields comparable to those measured in mammalian wounds. J. Cell Sci. 109(1), 199–207 (1996)
Nohe, A., Keating, E., Fivaz, M., van der Goot, F.G., Petersen, N.O.: Dynamics of GPI-anchored proteins on the surface of living cells. Nanomedicine 2, 1–7 (2006)
Nuccitelli, R.: A role for endogenous electric fields in wound healing. Curr. Top. Dev. Biol. 58, 1–26 (2003)
Ojingwa, J.C., Isseroff, R.R.: Electrical stimulation of wound healing. J. Invest. Dermatol. 121, 1–12 (2003)
Otter, M.W., McLeod, K.J., Rubin, C.T.: Effects of electromagnetic fields in experimental fracture repair. Clin. Orthop. Relat. Res. 355, 90–104 (1998)
Otter, M.W., Palmieri, V.R., Wu, D.D., Seiz, K.G., MacGinitie, L.A., Cochran, G.V.: A comparative analysis of streaming potentials in vivo and in vitro. J. Orthop. Res. 9, 710–719 (1992)
Otter, M.W., Porres, L., McLeod, K.J.: An investigation of the brownian ratchet in MC-3T3-E1 osteoblast-like cells using atomic force microscopy. Trans. Soc. Phys. Regul. Biol. Med. 16, 10–11 (1996)
Otter, M.W., Rubin, C.T., McLeod, K.J.: Can the response of bone to extremely weak stimuli be explained by the brownian ratchet? Ann. Biomed. Eng. 25(1), 76 (1997)
Peskin, C.S., Odell, G.M., Oster, G.F.: Cellular motions and thermal fluctuations: the brownian ratchet. Biophys. J. 65, 316–324 (1993)
Petrov, A.G.: Electricity and mechanics of biomembrane systems: flexoelectricity in living membranes. Anal. Chim. Acta 568, 70–83 (2006)
Pilla, A.A.: Weak time-varying and static magnetic fields: From mechanisms to therapeutic applications. In: Stavroulakis, P. (ed.) Biological Effects of Electromagnetic Fields: mechanisms, modeling, biological effects, therapeutic effects, International Standards Exposure Criteria. Springer, Berlin (2003)
Piva, P.G., DiLabio, G.A., Pitters, J.L., Zikovsky, J., Rezeq, M., Dogel, S., Hofer, W.A., Wolkow, R.A.: Field regulation of single-molecule conductivity by a charged surface atom. Nature 435, 658–661 (2005)
Plopper, G.E., McNamee, H.P., Dike, L.E., Bojanowski, K., Ingber, D.E.: Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol. Biol. Cell 6, 1349–1365 (1995)
Pullar, C.E., Rizzo, A., Isseroff, R.R.: beta-adrenergic receptor antagonists accelerate skin wound healing: evidence for a catecholamine synthesis network in the epidermis. J. Biol. Chem. 281(21), 225–235 (2006)
Raphael, R.M., Popel, A.S., Brownell, W.E.: A membrane bending model of outer hair cell electromotility. Biophys. J. 78, 2844–2862 (2000)
Robinson, K.R.: The responses of cells to electrical fields: a review. J. Cell Biol. 101, 2023–2027 (1985)
Robinson, K.R., Messerli, M.A.: Left/right, up/down: the role of endogenous electrical fields as directional signals in development, repair and invasion. Bioessays 25, 759–766 (2003)
Rosa, L.P., Faber, J.: Quantum models of the mind: are they compatible with environment decoherence? Phys. Rev. E Stat. Nonlinear Soft Matter Phys. 70, 31902 (2004)
Rose, S.M.: Bioelectric control of regeneration in tubularia. Am. Zool. 14, 797–803 (1974)
Rosenspire, A.J., Kindzelskii, A.L., Simon, B.J., Petty, H.R.: Real-time control of neutrophil metabolism by very weak ultra-low frequency pulsed magnetic fields. Biophys. J. 88, 3334–3347 (2005)
Schoen, I., Fromherz, P.: Extracellular stimulation of mammalian neurons through repetitive activation of \({\rm Na}^{+}\) channels by weak capacitive currents on a silicon chip. J. Neurophysiol. 100, 346–357 (2008)
Schwab, A., Nechyporuk-Zloy, V., Fabian, A., Stock, C.: Cells move when ions and water flow. Pflugers Arch 453, 421–432 (2007)
Shi, R., Borgens, R.B.: Three-dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern. Dev. Dyn. 202, 101–114 (1995)
Simeonova, M., Wachner, D., Gimsa, J.: Cellular absorption of electric field energy: influence of molecular properties of the cytoplasm. Bioelectrochemistry 56, 215–218 (2002)
Smith, C.: In: H. Fröhlich (ed.) Biological Coherence and Response to External Stimuli, 1st edn., pp. 549–566. Springer, Berlin (1988)
Song, B., Zhao, M., Forrester, J.V., McCaig, C.D.: Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo. Proc. Natl. Acad. Sci. USA 99(13), 577–582 (2002)
Soong, H.K., Parkinson, W.C., Bafna, S., Sulik, G.L., Huang, S.C.: Movements of cultured corneal epithelial cells and stromal fibroblasts in electric fields. Invest Ophthalmol Vis Sci 31, 2278–2282 (1990)
Stangl, C., Fromherz, P.: Neuronal field potential in acute hippocampus slice recorded with transistor and micropipette electrode. Eur. J. Neurosci. 27, 958–964 (2008)
Stern, C.D.: Experimental reversal of polarity in chick embryo epiblast sheets in vitro. Exp. Cell Res. 140, 468–471 (1982)
Stock, C., Gassner, B., Hauck, C.R., Arnold, H., Mally, S., Eble, J.A., Dieterich, P., Schwab, A.: Migration of human melanoma cells depends on extracellular pH and \({\rm Na}^{+}\)/\({\rm H}^{+}\) exchange. J. Physiol. 567, 225–238 (2005)
Stock, C., Schwab, A.: Role of the Na/H exchanger NHE1 in cell migration. Acta Physiol. (Oxf) 187, 149–157 (2006)
Sulik, G.L., Soong, H.K., Chang, P.C., Parkinson, W.C., Elner, S.G., Elner, V.M.: Effects of steady electric fields on human retinal pigment epithelial cell orientation and migration in culture. Acta Ophthalmol (Copenh) 70, 115–122 (1992)
Sun, S., Wise, J., Cho, M.: Human fibroblast migration in three-dimensional collagen gel in response to noninvasive electrical stimulus. I. characterization of induced three-dimensional cell movement. Tissue Eng. 10, 1548–1557 (2004)
Uzman, J.A., Patil, S., Uzgare, A.R., Sater, A.K.: The role of intracellular alkalinization in the establishment of anterior neural fate in Xenopus. Dev Biol 193, 10–20 (1998)
Valberg, P.A., Kavet, R., Rafferty, C.N.: Can low-level 50/60 Hz electric and magnetic fields cause biological effects? Radiat. Res. 148, 2–21 (1997)
Wan, C., Fiebig, T., Kelley, S.O., Treadway, C.R., Barton, J.K., Zewail, A.H.: Femtosecond dynamics of DNA-mediated electron transfer. Proc. Natl. Acad. Sci. USA 96, 6014–6019 (1999)
Wang, E., Zhao, M., Forrester, J.V., McCaig, C.D.: Bi-directional migration of lens epithelial cells in a physiological electrical field. Exp. Eye Res. 76, 29–37 (2003)
Wang, E., Zhao, M., Forrester, J.V., et al.: Re-orientation and faster, directed migration of lens epithelial cells in a physiological electric field. Exp. Eye Res. 71, 91–98 (2000)
Wenger, O.S., Leigh, B.S., Villahermosa, R.M., Gray, H.B., Winkler, J.R.: Electron tunneling through organic molecules in frozen glasses. Science 307, 99–102 (2005)
Woodruff, R.I.: Calmodulin transit via gap junctions is reduced in the absence of an electric field. J. Insect Physiol. 51, 843–852 (2005)
Xie, T.D., Chen, Y., Marszalek, P., Tsong, T.Y.: Fluctuation-driven directional flow in biochemical cycle: further study of electric activation of NaK pumps. Biophys. J. 72, 2496–2502 (1997)
Xie, T.D., Marszalek, P., Chen, Y.D., Tsong, T.Y.: Recognition and processing of randomly fluctuating electric signals by Na. K-ATPase. Biophys. J. 67, 1247–1251 (1994)
Yoda, A., Clark, A.W., Yoda, S.: Reconstitution of (\({{\rm Na}^{+}}{+}{{\rm K}^{+}}\))-ATPase proteoliposomes having the same turnover rate as the membranous enzyme. Biochim. Biophys. Acta 778, 332–340 (1984)
Yu, S.R., Burkhardt, M., Nowak, M., Ries, J., Petrasek, Z., Scholpp, S., Schwille, P., Brand, M.: Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature 461, 533–536 (2009)
Zhao, M., Dick, A., Forrester, J.V., McCaig, C.D.: Electric field-directed cell motility involves up-regulated expression and asymmetric redistribution of the epidermal growth factor receptors and is enhanced by fibronectin and laminin. Mol. Biol. Cell 10, 1259–1276 (1999)
Zhao, M., Forrester, J.V., McCaig, C.D.: A small, physiological electric field orients cell division. Proc. Natl. Acad. Sci. U. S. A. 96, 4942–4946 (1999)
Zhao, M., McCaig, C.D., Agius-Fernandez, A., Forrester, J.V., Araki-Sasaki, K.: Human corneal epithelial cells reorient and migrate cathodally in a small applied electric field. Curr. Eye Res. 16, 973–984 (1997)
Zhao, M., Pu, J., Forrester, J.V., McCaig, C.D.: Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric field. FASEB J. 16, 857–859 (2002)
Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, J.V., Bourne, H.R., Devreotes, P.N., McCaig, C.D., Penninger, J.M.: Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 442, 457–460 (2006)
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Funk, R.H.W. (2012). Electromagnetic Aspects in Cell Biology. In: Gerlach, G., Wolter, KJ. (eds) Bio and Nano Packaging Techniques for Electron Devices. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28522-6_22
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