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Modeling and Simulation for Dynamics of Anti-HBV Infection Therapy

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Advances in Automation and Robotics, Vol. 2

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 123))

Abstract

Based on our previous researches, this paper introduces a new differential equation model to describe the dynamics of traditional Chinese medicines (TCM) + nucleoside analogues (NA) anti-HBV infection treatment for the chronic hepatitis B (CHB) patients. This model has five state variables. A treatment-activated specific term in this model is in charge of directly clearing patients’ HBV rather than damaging patients’ hepatocytes. As an application, we use this model to simulate the dynamics of TCM + NA anti-HBV infection personalized combination treatments. The numerical simulations and analysis show that the TCM + NA combination treatments are able to activate patients’ abilities of cytokine-midiated noncytolytic HBV clearance.

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Author information

Authors and Affiliations

  1. Automation School, University of Science and Technology Beijing, Beijing, 100083, China

    Xiao Chen, Lequan Min & Yu Zheng

  2. Mathematics and Physics School, University of Science and Technology Beijing, Beijing, 100083, China

    Lequan Min

  3. Traditional Chinese Internal Medicine Key Laboratory of China Education Ministry, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Yongan Ye

Authors
  1. Xiao Chen
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  2. Lequan Min
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  3. Yongan Ye
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  4. Yu Zheng
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Editor information

Editors and Affiliations

  1. Information Engineering Research Institute , 100 Continental Dr, 19713, Newark, DE, USA

    Gary Lee

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© 2011 Springer-Verlag Berlin Heidelberg

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Chen, X., Min, L., Ye, Y., Zheng, Y. (2011). Modeling and Simulation for Dynamics of Anti-HBV Infection Therapy. In: Lee, G. (eds) Advances in Automation and Robotics, Vol. 2. Lecture Notes in Electrical Engineering, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25646-2_73

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  • DOI: https://doi.org/10.1007/978-3-642-25646-2_73

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25645-5

  • Online ISBN: 978-3-642-25646-2

  • eBook Packages: EngineeringEngineering (R0)

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