Abstract
In this paper, the authors first show that if R 0 ≤ 1, the infection free steady state is globally attractive by using approaches different from those given by Min, et al.(2008). Then the authors prove that if R 0 > 1, the endemic steady state is also globally attractive. Finally, based on a patient’s clinical HBV DNA data of anti-HBV infection with drug lamivudine, the authors establish an ABVIM. The numerical simulations of the ABVIM are good in agreement with the clinical data.
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This research is supported by the National Natural Science Foundations of China under Grant No. 60674059, the 11th 5-Year Plan Key Research Project of China under Grant No. 2004BA721A03, the China National Key Special Project for the Preventions and Cures of Important Infectious Diseases under Grant No. 2008ZX10005-006.
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Zheng, Y., Min, L., Ji, Y. et al. Global stability of endemic equilibrium point of basic virus infection model with application to HBV infection. J Syst Sci Complex 23, 1221–1230 (2010). https://doi.org/10.1007/s11424-010-8467-0
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DOI: https://doi.org/10.1007/s11424-010-8467-0