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Ligands for Ionotropic Glutamate Receptors

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Marine Toxins as Research Tools

Part of the book series: Progress in Molecular and Subcellular Biology ((MMB,volume 46))

Abstract

Marine-derived small molecules and peptides have played a central role in elaborating pharmacological specificities and neuronal functions of mammalian ionotropic glutamate receptors (iGluRs), the primary mediators of excitatory syn-aptic transmission in the central nervous system (CNS). As well, the pathological sequelae elicited by one class of compounds (the kainoids) constitute a widely-used animal model for human mesial temporal lobe epilepsy (mTLE). New and existing molecules could prove useful as lead compounds for the development of therapeutics for neuropathologies that have aberrant glutamatergic signaling as a central component. In this chapter we discuss natural source origins and pharmacological activities of those marine compounds that target ionotropic glutamate receptors.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL, 60611

    Geoffrey T. Swanson

  2. Faculty of Fisheries Sciences, Hokkaido University, Hakodate, 041-8611, Japan

    Ryuichi Sakai

Authors
  1. Geoffrey T. Swanson
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  2. Ryuichi Sakai
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Editors and Affiliations

  1. Hokkaido University, 3-1-1 Minato-cho, Hakodate, 041-8611, Japan

    Nobuhiro Fusetani (Faculty of Fisheries Sciences) (Faculty of Fisheries Sciences)

  2. Department of Pharmacology & Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL, 32610-0267, USA

    William Kem

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© 2009 Springer-Verlag Berlin Heidelberg

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Swanson, G.T., Sakai, R. (2009). Ligands for Ionotropic Glutamate Receptors. In: Fusetani, N., Kem, W. (eds) Marine Toxins as Research Tools. Progress in Molecular and Subcellular Biology, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87895-7_5

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