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Marine Toxins as Research Tools

  • Nobuhiro Fusetani
  • William Kem

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 46)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Nobuhiro Fusetani
    Pages 1-44
  3. Richard J. Lewis
    Pages 45-65
  4. Lyndon E. Llewellyn
    Pages 67-97
  5. Sylvie Diochot, Michel Lazdunski
    Pages 99-122
  6. Geoffrey T. Swanson, Ryuichi Sakai
    Pages 123-157
  7. Frédéric A. Meunier, César Mattei, Jordi Molgó
    Pages 159-186
  8. Hirota Fujiki, Masami Suganuma
    Pages 221-254
  9. Back Matter
    Pages 255-259

About this book

Introduction

Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.

Keywords

Glutamat biological functions drug discovery marine organisms marine toxins protein

Editors and affiliations

  • Nobuhiro Fusetani
    • 1
  • William Kem
    • 2
  1. 1.Hokkaido UniversityHakodateJapan
  2. 2.Department of Pharmacology & TherapeuticsUniversity of FloridaGainesvilleUSA

Bibliographic information