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Orthobiologics: Today and Tomorrow

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Cartilage Restoration

Abstract

Biologic-based therapy for cartilage pathology has gained considerable recognition due to being minimally invasive, offering capacity for faster healing, and potential for rapid recovery. These therapies include tissue-specific cell culture, marrow-venting procedures, platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and cell-based therapies. Reports thus far have yielded promising results with a relatively robust safety profile. Although important advances have been made in the field, further well-designed clinical trials are required. Current limitations include their high cost and limited long-term evidence of efficacy. This chapter aims to review the existing literature for biologic-based treatment options for cartilage and identify potential avenues for development.

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Author information

Authors and Affiliations

  1. School of Clinical Medicine, University of Cambridge, Cambridge, UK

    Zaamin B. Hussain

  2. Department of Sports Medicine, Santa Monica Orthopedic and Sports Medicine Group, Santa Monica, CA, USA

    Jorge Chahla

  3. The Steadman Clinic, Vail, CO, USA

    Robert F. LaPrade

  4. Cedars Sinai – Kerlan Jobe Institute, Santa Monica, CA, USA

    Bert R. Mandelbaum

Authors
  1. Zaamin B. Hussain
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  2. Jorge Chahla
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  3. Robert F. LaPrade
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  4. Bert R. Mandelbaum
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Editors and Affiliations

  1. OrthoIndy Knee Preservation and Cartilage Restoration Center of Indiana, Indianapolis, Indiana, USA

    Jack Farr

  2. Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York, USA

    Andreas H. Gomoll

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Hussain, Z.B., Chahla, J., LaPrade, R.F., Mandelbaum, B.R. (2018). Orthobiologics: Today and Tomorrow. In: Farr, J., Gomoll, A. (eds) Cartilage Restoration. Springer, Cham. https://doi.org/10.1007/978-3-319-77152-6_11

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