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Two-Photon Polymerization in Tissue Engineering

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Polymer and Photonic Materials Towards Biomedical Breakthroughs

Abstract

In tissue engineering, three-dimensional scaffolds, which should ensure necessary mechanical and biological microenvironment and nutrient, oxygen and grow factor delivery to proliferating cells, are an essential element. They can be formed from polymeric, ceramic and hybrid materials via different techniques. Modern laser fabrication methods, which provide high accuracy of positioning and energy focusing and allow the precise porous scaffold formation, are particularly interesting. Two-photon polymerization is one of the most promising laser-based techniques and permits the use of a large material variety for scaffold fabrication with the possibility of controlling accurately their microarchitecture. While the number of studies on two-photon polymerization is constantly growing, it is crucial to provide a framework of its application in tissue engineering. Therefore, this chapter aims to describe recent achievements and examples of two-photon polymerization application in tissue engineering and to reveal the main trends in this field.

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Abbreviations

2PP:

Two-photon polymerization

3D:

Three-dimensional

ECM:

Extracellular matrix

TE:

Tissue engineering

TPA:

Two-photon absorption

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, Moscow, Russia

    Anastasia Shpichka & Peter Timashev

  2. Laser Zentrum Hannover e.V, Hannover, Germany

    Anastasia Koroleva

  3. Nizhny Novgorod State Medical Academy, Institute of Biomedical Technologies, Nizhny Novgorod, Russia

    Daria Kuznetsova

  4. Baikal Institute of Nature Management, Siberian Branch of the Russian Academy of Sciences, Ulan-Ude, Russia

    Vitaliy Burdukovskii

  5. Leibniz Universität Hannover, Institute of Quantum Optics, Hannover, Germany

    Boris Chichkov

  6. Research Center “Crystallography and Photonics” RAS, Institute of Photonic Technologies, Moscow, Russia

    Viktor Bagratashvilі & Peter Timashev

Authors
  1. Anastasia Shpichka
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  2. Anastasia Koroleva
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  3. Daria Kuznetsova
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  4. Vitaliy Burdukovskii
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  5. Boris Chichkov
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  6. Viktor Bagratashvilі
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  7. Peter Timashev
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Editor information

Editors and Affiliations

  1. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Jasper Van Hoorick

  2. Brussels Photonics, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Brussel, Belgium

    Heidi Ottevaere

  3. Brussels Photonics, Department of Applied Physics and Photonics, Vrije Universiteit Brussel, Brussel, Belgium

    Hugo Thienpont

  4. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Peter Dubruel

  5. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, Belgium

    Sandra Van Vlierberghe

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Shpichka, A. et al. (2018). Two-Photon Polymerization in Tissue Engineering. In: Van Hoorick, J., Ottevaere, H., Thienpont, H., Dubruel, P., Van Vlierberghe, S. (eds) Polymer and Photonic Materials Towards Biomedical Breakthroughs. Micro- and Opto-Electronic Materials, Structures, and Systems. Springer, Cham. https://doi.org/10.1007/978-3-319-75801-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-75801-5_3

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