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Introduction to Interrelated Biology of Age-Associated Chronic Diseases and Cancer: Chronic Inflammation, a Common Denominator in Morbidity and Mortality

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Inflammation, Aging and Cancer

Abstract

The biological events that regulate the body’s multi-organ systems from conception to development and through adulthood and aging process are fascinating molecular communications between immune and non-immune systems. The highly organized interdependent network of signals and chemical interactions (crosstalk) among the organ systems such as immune cells, vasculature, neuronal, metabolic hormonal pathways constitute the body’s effective immunity that defend the body against any intrinsic or extrinsic components that are perceived hazardous. Body’s protection against all unwanted elements was originally conceptualized as the theory of immune surveillance that also defined control of cancer growth; by Sir Mc Farland Burnet in 1957. Disturbance of the orchestrated crosstalk in immunity by frequent exposures to various immune disruptors, including pathogen-specific vaccines and aging process can cause retardation of various interrelated communications in susceptible tissues and initiation of mild or severe health conditions. In this introductory chapter we overviewed the topics that are detailed separately throughout the book. It is suggested that policy makers and professionals in decision making roles in medical sciences to return to common sense and logics that our Forefathers used to serve the public. Future directions in medical cancer research are suggested to be systematical studies of oxidative stress initiating events that disturb the effective immunity (immune surveillance) toward multistep disease processes.

We could certainly slow the aging process down if it had to work its way through Congress

Will Rogers

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Notes

  1. 1.

    Davis K, Stremikis K, Schoen C, Squires D: Mirror, Mirror on the Wall, 2014 Update: How the U.S. Health Care System Compares Internationally, The Commonwealth Fund, June 2014.

  2. 2.

    Medscape December 5, 2011 (Washington DC) reported by Dr. Foji (NCI) ‘zero [is] the number of targeted therapies that prolonged survival by 1 year’ when compared with conventional treatment.

  3. 3.

    Bennett, A. (2010) End-of-life warning at $618,616 makes me wonder was it worth it, Mar. 4. Bloomberg News. http://www.bloomberg.com/apps/news?pid=newsarchive&sid=avRFGNF6Qw_w

  4. 4.

    Berger, E. (2012) Interview with the president of MD Anderson, DePinho in CNBC program, June 1, 2012, http://blog.chron.com/sciguy/2012/06/m-d-anderson-president-goes-on-cnbc-extols-his-own-company.

  5. 5.

    In 1980s, the author was also studying the role of glucose toxicity in ocular tissues to understand biology of diabetes complications with focus on retinopathy and maculopathy (examples in Ref. [90,91,92,93,94]). This was a tremendous thought-provoking period for author’s professional life and bases for her desire to integrate useful data from multidisciplinary fields of biomedical sciences and extend earlier discoveries to better understand the biology of cancer.

  6. 6.

    Philip Zelikow was one of the architects behind creation of war against powerless nations.

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  1. Bethesda, Maryland, USA

    Mahin Khatami

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Khatami, M. (2017). Introduction to Interrelated Biology of Age-Associated Chronic Diseases and Cancer: Chronic Inflammation, a Common Denominator in Morbidity and Mortality. In: Inflammation, Aging and Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-66475-0_1

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