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Dosimetry in PRRT

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Clinical Applications of Nuclear Medicine Targeted Therapy

Abstract

Peptide receptor radionuclide therapy (PRRT) with 90Y- and 177Lu-radiolabelled peptides represents a promising option for patients with somatostatin receptor-expressing tumours. Several clinical trials have proven its efficacy and a general profile of low toxicity. Although in a minority of patients, severe events of kidney toxicity have occurred, so the kidneys represent the organ at risk, especially for 90Y-peptides, followed by red marrow, as also haematological toxicity, rarely at high grade, may occur in both 90Y- and 177Lu-PRRT. The results of some studies have shown important dose-effect correlations, especially for renal damage, showing the possibility not only to avoid unwanted effects when absorbed dose prescriptions are respected but also to optimise therapy. However, due to the large variability of biokinetics among patients, individual dosimetry is necessary for tailored PRRT.

The following chapter summarises the methods for PRRT dosimetry and the major dosimetric and radiobiological results present in the literature, highlighting correlations and challenging perspectives. Possible approaches for simplified dosimetry are also described.

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Authors and Affiliations

  1. Istituto Europeo di Oncologia, Milan, Italy

    Marta Cremonesi, Mahila Ferrari & Francesca Botta

Authors
  1. Marta Cremonesi
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  2. Mahila Ferrari
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  3. Francesca Botta
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Corresponding author

Correspondence to Marta Cremonesi .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Emilio Bombardieri

  2. Nuclear Medicine Therapy and Endocrinology, Istituto Nazionale dei Tumori, Milano, Italy

    Ettore Seregni

  3. Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy

    Laura Evangelista

  4. Nuclear Medicine Division, Istituto Nazionale dei Tumori, Milano, Italy

    Carlo Chiesa

  5. Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milano, Italy

    Arturo Chiti

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Cremonesi, M., Ferrari, M., Botta, F. (2018). Dosimetry in PRRT. In: Bombardieri, E., Seregni, E., Evangelista, L., Chiesa, C., Chiti, A. (eds) Clinical Applications of Nuclear Medicine Targeted Therapy . Springer, Cham. https://doi.org/10.1007/978-3-319-63067-0_23

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