Abstract
Intraoperative MRI (ioMRI) dates back to the 1990s and since then has been successfully applied in neurosurgery for three primary reasons with the last one becoming the most significant today: (1) brain shift-corrected navigation, (2) monitoring/controlling thermal ablations, and (3) identifying residual tumor for resection. IoMRI, which today is moving into other applications, including treatment of vasculature and the spine, requires advanced 3T MRI platforms for faster and more flexible image acquisitions, higher image quality, and better spatial and temporal resolution; functional capabilities including fMRI and DTI; non-rigid registration algorithms to register pre- and intraoperative images; non-MRI imaging improvements to continuously monitor brain shift to identify when a new 3D MRI data set is needed intraoperatively; more integration of imaging and MRI-compatible navigational and robot-assisted systems; and greater computational capabilities to handle the processing of data. The Brigham and Women’s Hospital’s “AMIGO” suite is described as a setting for progress to continue in ioMRI by incorporating other modalities including molecular imaging. A call to action is made to have other researchers and clinicians in the field of image guided therapy to work together to integrate imaging with therapy delivery systems (such as laser, MRgFUS, endoscopic, and robotic surgery devices).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Black PM, Alexander E 3rd, Martin C et al (1999) Craniotomy for tumor treatment in an intraoperative magnetic resonance imaging unit. Neurosurgery 45(3):423–431
Dimaio SP, Archip N, Hata N et al (2006) Image-guided neurosurgery at Brigham and Women’s Hospital. IEEE Eng Med Biol Mag 25(5):67–73
Hall WA, Martin AJ, Liu H et al (1998) High-field strength interventional magnetic resonance imaging for pediatric neurosurgery. Pediatr Neurosurg 29(5):253–259
Jolesz FA, Talos IF, Schwartz RB et al (2002) Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors. Neuroimaging Clin N Am 12(4):665–683
Lewin JS, Metzger AK (2001) Intraoperative MR systems. Low-field approaches. Neuroimaging Clin N Am 11(4):611–628
Schenck JF, Jolesz FA, Roemer PB, Cline HE, Lorensen WE, Kikinis R et al (1995) Superconducting open-configuration MR imaging system for image-guided therapy. Radiology 195(3):805–814
Schwartz RB, Hsu L, Wong TZ et al (1999) Intraoperative MR imaging guidance for intracranial neurosurgery: experience with the first 200 cases. Radiology 211(2):477–488
Schulder M, Liang D, Carmel PW (2001) Cranial surgery navigation aided by a compact intraoperative magnetic resonance imager. J Neurosurg 94(6):936–945
Steinmeier R, Fahlbusch R, Ganslandt O et al (1998) Intraoperative magnetic resonance imaging with the magnetom open scanner: concepts, neurosurgical indications, and procedures: a preliminary report. Neurosurgery 43(4):739–747, discussion 747–748
Sutherland GR, Kaibara T, Louw D, Hoult DI, Tomanek B, Saunders J (1999) A mobile high-field magnetic resonance system for neurosurgery. J Neurosurg 91(5):804–813
Jolesz FA, Kikinis R, Talos IF (2001) Neuronavigation in interventional MR imaging. Frameless stereotaxy. Neuroimaging Clin N Am 11(4):685–689
Nabavi A, Black PM, Gering DT et al (2001) Serial intraoperative magnetic resonance imaging of brain shift. Neurosurgery 48(4):787–797, discussion 797–798
Anzai Y, Lufkin R, DeSalles A, Hamilton DR, Farahani K, Black KL (1995) Preliminary experience with MR-guided thermal ablation of brain tumors. AJNR Am J Neuroradiol 16(1):39–48, discussion 49–52
Ascher PW, Justich E, Schröttner O (1991) Interstitial thermotherapy of central brain tumors with the Nd:YAG laser under real-time monitoring by MRI. J Clin Laser Med Surg 9(1):79–83
Bettag M, Ulrich F, Schober R et al (1991) Stereotactic laser therapy in cerebral gliomas. Acta Neurochir Suppl (Wien) 52:81–83
Fan M, Ascher PW, Schröttner O, Ebner F, Germann RH, Kleinert R (1992) Interstitial 1.06 Nd:YAG laser thermotherapy for brain tumors under real-time monitoring of MRI: experimental study and phase I clinical trial. J Clin Laser Med Surg 10(5):355–356
Kahn T, Bettag M, Ulrich F et al (1994) MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms. J Comput Assist Tomogr 18:519–532
Kettenbach J, Silverman SG, Hata N et al (1998) Monitoring and visualization techniques for MR-guided laser ablations in an open MR system. J Magn Reson Imaging 8(4):933–943
McDannold NJ, Jolesz FA (2000) Magnetic resonance image-guided thermal ablations. Top Magn Reson Imaging 11(3):191–202
Stollberger R, Ascher PW, Huber D, Renhart W, Radner H, Ebner F (1998) Temperature monitoring of interstitial thermal tissue coagulation using MR phase images. J Magn Reson Imaging 8(1):188–196
Cline HE, Hynynen K, Watkins RD et al (1995) Focused US system for MR imaging-guided tumor ablation. Radiology 194(3):731–737
Hynynen K, Vykhodtseva NI, Chung AH, Sorrentino V, Colucci V, Jolesz FA (1997) Thermal effects of focused ultrasound on the brain: determination with MR imaging. Radiology 204(1):247–253
Jolesz FA, Hynynen K (2002) Magnetic resonance image-guided focused ultrasound surgery. Cancer J 8(suppl 1):S100–S112
Jolesz FA, Hynynen K, McDannold N, Tempany C (2005) MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin N Am 13(3):545–60
Jolesz FA, McDannold N (2008) Current status and future potential of MRI-guided focused ultrasound surgery. J Magn Reson Imaging 27(2):391–399
McDannold N, Hynynen K, Wolf D, Wolf G, Jolesz F (1998) MRI evaluation of thermal ablation of tumors with focused ultrasound. J Magn Reson Imaging 8(1):91–100
Claus EB, Horlacher A, Hsu L (2005) Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance. Cancer 103(6):1227–1233
Mittal S, Black PM (2006) Intraoperative magnetic resonance imaging in neurosurgery: the Brigham concept. Acta Neurochir Suppl 98:77–86
Nimsky C, Fujita A, Ganslandt O, Von Keller B, Fahlbusch R (2004) Volumetric assessment of glioma removal by intraoperative high-field magnetic resonance imaging. Neurosurgery 55(2):358–370, discussion 370–371
Bradley WG (2002) Achieving gross total resection of brain tumors: intraoperative MR imaging can make a big difference. AJNR Am J Neuroradiol 23(3):348–349
Nimsky C, Ganslandt O, Von Keller B, Romstöck J, Fahlbusch R (2004) Intraoperative high-field-strength MR imaging: implementation and experience in 200 patients. Radiology 233(1):67–78
Truwit CL, Hall WA (2006) Intraoperative magnetic resonance imaging-guided neurosurgery at 3-T. Neurosurgery 58(4 suppl 2):ONS-338–345, discussion ONS-345–346
Hall WA, Liu H, Truwit CL (2005) Functional magnetic resonance imaging-guided resection of low-grade gliomas. Surg Neurol 64(1):20–27, discussion
Golby AJ, McConnell KA (2004) Functional brain mapping options for minimally invasive surgery. In: Black PM, Proctor M (eds) Minimally invasive neurosurgery. Humana Press, Totawa, NJ, pp 87–106
Nimsky C, Ganslandt O, Kober H et al (1999) Integration of functional magnetic resonance imaging supported by magnetoencephalography in functional neuronavigation. Neurosurgery 44(6):1249–1255, discussion 1255–1256
Gering DT, Nabavi A, Kikinis R et al (2001) An integrated visualization system for surgical planning and guidance using image fusion and an open MR. J Magn Reson Imaging 13(6):967–975
Nabavi A, Gering DT, Kacher DF et al (2003) Surgical navigation in the open MRI. Acta Neurochir Suppl 85:121–125
Nimsky C, Ganslandt O, Cerny S, Hastreiter P, Greiner G, Fahlbusch R (2000) Quantification of, visualization of, and compensation for brain shift using intraoperative magnetic resonance imaging. Neurosurgery 47(5):1070–1079, discussion 1079–1080
Nimsky C, Ganslandt O, Hastreiter P, Fahlbusch R (2001) Intraoperative compensation for brain shift. Surg Neurol 56(6):357–364, discussion 364–365
Clatz O, Delingette H, Talos IF et al (2005) Hybrid formulation of the model-based non-rigid registration problem to improve accuracy and robustness. Med Image Comput Comput Assist Interv 8(Pt 2):295–302
Ferrant M, Nabavi A, Macq B et al (2002) Serial registration of intraoperative MR images of the brain. Med Image Anal 6(4):337–359
Warfield SK, Haker SJ, Talos IF et al (2005) Capturing intraoperative deformations: research experience at Brigham and Women’s Hospital. Med Image Anal 9(2):145–162
White PJ, Whalen S, Tang SC, Clement G, Jolesz F, Golby AJ (2009) An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med 28(2):191–203
Chinzei K, Miller K (2001) Towards MRI guided surgical manipulator. Med Sci Monit 7(1):153–163
Chinzei K, Warfield S, Hata N, Tempany C, Jolesz F, Kikinis R (2003) Planning, simulation and assistance with intraoperative MRI. Minim Invasive Ther Allied Technol 12(1):59–64
DiMaio SP, Pieper S, Chinzei K et al (2007) Robot-assisted needle placement in open MRI: system architecture, integration and validation. Comput Aided Surg 12(1):15–24
Elhawary H, Tse ZT, Hamed A, Rea M, Davies BL, Lamperth MU (2008) The case for MR-compatible robotics: a review of the state of the art. Int J Med Robot 4(2):105–113
Elhawary H, Zivanovic A, Davies B, Lampérth M (2006) A review of magnetic resonance imaging compatible manipulators in surgery. Proc Inst Mech Eng 220(3):413–424
Masamune K, Kobayashi E (1995) Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. J Image Guid Surg 1(4):242–248
Sutherland GR, Latour I, Greer AD (2008) Integrating an image-guided robot with intraoperative MRI: a review of the design and construction of neuroArm. IEEE Eng Med Biol Mag 27(3):59–65
Sutherland GR, Latour I, Greer AD, Fielding T, Feil G, Newhook P (2008) An image-guided magnetic resonance-compatible surgical robot. Neurosurgery 62(2):286–292, discussion 292–293
Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA (2001) Noninvasive MR imaging-guided focal opening of the blood–brain barrier in rabbits. Radiology 220(3):640–646
Kinoshita M, McDannold N, Jolesz FA, Hynynen K (2006) Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun 340(4):1085–1090
Kinoshita M, McDannold N, Jolesz FA, Hynynen K (2006) Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption. Proc Natl Acad Sci U S A 103(31):11719–11723
Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K (2007) Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 121(4):901–907
Vykhodtseva N, McDannold N, Hynynen K (2006) Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and optison. Ultrasound Med Biol 32(12):1923–1929
Yoo SS, Lee JH, Zhang Y et al (2008) FUS-mediated reversible modulation of region-specific brain function. Proc MRgFUS 2008:10
Colucci V, Strichartz G, Jolesz F, Vykhodtseva N, Hynynen K (2009) Focused ultrasound effects on nerve action potential in vitro. Ultrasound Med Biol 35(10):1737–1747
Currier DP, Greathouse D, Swift T (1978) Sensory nerve conduction: effect of ultrasound. Arch Phys Med Rehabil 59(4):181–185
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag/Wien
About this chapter
Cite this chapter
Jolesz, F.A. (2011). Intraoperative Imaging in Neurosurgery: Where Will the Future Take Us?. In: Pamir, M., Seifert, V., Kiris, T. (eds) Intraoperative Imaging. Acta Neurochirurgica Supplementum, vol 109. Springer, Vienna. https://doi.org/10.1007/978-3-211-99651-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-211-99651-5_4
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99650-8
Online ISBN: 978-3-211-99651-5
eBook Packages: MedicineMedicine (R0)